A review on recent advances in chitosan based composite for hemostatic dressings

Khan, Munezza Ata; Mujahid, Mohammad

doi:10.1016/j.ijbiomac.2018.11.045

Cited by 172 publications

(98 citation statements)

References 67 publications

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“…CS has very strong hemostatic activity which is not dependent on host coagulation pathway [23] but depends on CS's molecular weight and DD [24,25]. The number of amine groups has a direct effect on blood coagulation, where moderate DD (68.36%) causes the formation of a mesh-like structure within CS, thus facilitating interaction with blood components, whereas higher DD results in stronger hydrogen bonds within CS causing the formation of a crystalline structure with limited ability to interact with red blood cells [24][25][26][27].…”

Section: Chitosan For Wound Healingmentioning

confidence: 99%

Progress in the Development of Chitosan-Based Biomaterials for Tissue Engineering and Regenerative Medicine

et al. 2019

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Over the last few decades, chitosan has become a good candidate for tissue engineering applications. Derived from chitin, chitosan is a unique natural polysaccharide with outstanding properties in line with excellent biodegradability, biocompatibility, and antimicrobial activity. Due to the presence of free amine groups in its backbone chain, chitosan could be further chemically modified to possess additional functional properties useful for the development of different biomaterials in regenerative medicine. In the current review, we will highlight the progress made in the development of chitosan-containing bioscaffolds, such as gels, sponges, films, and fibers, and their possible applications in tissue repair and regeneration, as well as the use of chitosan as a component for drug delivery applications.

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Section: Chitosan For Wound Healingmentioning

confidence: 99%

Progress in the Development of Chitosan-Based Biomaterials for Tissue Engineering and Regenerative Medicine

et al. 2019

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“…The advanced TOLs content of film showed the lower porosity as well as stronger hydrophobicity on the surface of pore wall, leading to the decreased amount of amino cation which played an important role in clotting. 56 Bleeding emerged only in the early stage of wound healing and a trace of blood is usually secreted in chronic wounds so that the TOLs-CS/PEO nanofibrous films prepared in this study can suffice for the needs of hemostasis.…”

Section: In Vitro Hemostasis Capability and In Vitro Degradationmentioning

confidence: 95%

Terpinen‐4‐ol liposomes‐incorporated chitosan/polyethylene oxide electrospun nanofibrous film ameliorates the external microenvironment of healing cutaneous wounds

Yan

Tang

et al. 2020

J of Applied Polymer Sci

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Chronic wounds are susceptible to infection and difficult to heal due to the complex healing process and terrible microenvironment. In order to overcome this problem, TOLs‐CS/PEO nanofibrous film was successfully electrospun. The 6%(v/v) TOLs incorporation into CS/PEO nanofibrous film could improve the morphology and structure of nanofibers, weaken the interactions among macromolecules and rebalance the relationship between hydrophilicity and hydrophobicity of pore surface. Water vapor transmission rate and simulated tissue fluid absorption of films were optimized to reach 2193 g m−2 d−1 and 1676% so that to obtain the excellent moisture retention. The Young's modulus and elongation at break of films in wet state were 114.69 kPa and 72.04%, respectively, causing the mechanical characteristics similar to human skin. The film could effectively block more than 98% of bacteria and inhibit bacteria growth besides possessing procoagulant property and suitable biodegradability. These findings demonstrate that TOLs‐CS/PEO nanofibrous film can construct a microenvironment suitable for wound healing.

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“…Chitosan is a widely used biopolymer with unique bioactivities, including hemostatic activities [147]. A number of chitosan-based hemostatic products have been developed for the US military and have gone through a number of generations [52,148]. These products are manufactured in the forms of wafer, roll and granule.…”

Section: Chitosan-based Hemostatic Agentsmentioning

confidence: 99%

“…Since chitosan works primarily via direct electrostatic interaction between its positively charged amino groups and the negatively charged cell membranes of erythrocytes, independent of the host coagulation pathway, chitosan-based hemostatic products may also be able to stop coagulopathic bleeding [148]. Extensive evaluations in large animal models of severe bleeding have been conducted to demonstrate their hemostatic efficacy and safety, mostly in comparison with Combat Gauze [149].…”

Section: Chitosan-based Hemostatic Agentsmentioning

confidence: 99%

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Hemostatic agents for prehospital hemorrhage control: a narrative review

Peng

2020

Military Med Res

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Hemorrhage is the leading cause of preventable death in combat trauma and the secondary cause of death in civilian trauma. A significant number of deaths due to hemorrhage occur before and in the first hour after hospital arrival. A literature search was performed through PubMed, Scopus, and Institute of Scientific Information databases for English language articles using terms relating to hemostatic agents, prehospital, battlefield or combat dressings, and prehospital hemostatic resuscitation, followed by cross-reference searching. Abstracts were screened to determine relevance and whether appropriate further review of the original articles was warranted. Based on these findings, this paper provides a review of a variety of hemostatic agents ranging from clinically approved products for human use to newly developed concepts with great potential for use in prehospital settings. These hemostatic agents can be administered either systemically or locally to stop bleeding through different mechanisms of action. Comparisons of current hemostatic products and further directions for prehospital hemorrhage control are also discussed.

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A review on recent advances in chitosan based composite for hemostatic dressings

Cited by 172 publications

References 67 publications

Progress in the Development of Chitosan-Based Biomaterials for Tissue Engineering and Regenerative Medicine

Progress in the Development of Chitosan-Based Biomaterials for Tissue Engineering and Regenerative Medicine

Terpinen‐4‐ol liposomes‐incorporated chitosan/polyethylene oxide electrospun nanofibrous film ameliorates the external microenvironment of healing cutaneous wounds

Hemostatic agents for prehospital hemorrhage control: a narrative review

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