A Review on Recent Advancement in Pulsatile Drug Delivery Systems

Abstract

Delivery systems with a pulsatile-release method are particularly involved in designing medicines for which traditional managed drug-release systems with the continuous release are not suitable. This medication also has a high first-pass impact or special conditions for chrono-pharmacology. These medications also have a high first-pass or unique chronopharmacological effect. The pulsatile release profile is characterised by a duration of no release (lag time) followed by a fast and full release of the drug. Pulsatile drug delivery systems may be classified into site-specific systems in which the drug is released inside the gastrointestinal system (e. g. colon) or time-controlled devices wherein the drug is released after a well-defined time period. Site-regulated release is typically controlled by environmental factors, such as pH or enzymes found in the intestinal tract, whereas drug release from time-controlled processes is controlled mainly by the delivery system and, preferably, not by the environment. This review covers various single-and multiple-unit oral pulsatile drug-delivery systems with an emphasis on time-controlled drug-release systems.

Pulsatile Drug Delivery Systems the Novel Approach

“…Medication loss is prevented by first-pass metabolism. and No danger of dose dumping, they avoid Plasma Peak Concentration variations (Fluctuations) and administer medication at the site of movement at constant levels [16]. It will improve the absorption and bioavailability at the intended site of absorption due to its burst delivery mechanism.…”

“…Where steady medication release is not desired, pulsatile drug release is preferable. A pulse must be produced so that a complete and fast medication release is accomplished after the lag time chance to coordinate with the body's circadian rhythm [16]. These systems are characterized by two release phases.…”

Formulation Development and Evaluation of Chronomodulated Drug Delivery System by Zafirlukast

“…Depending upon the physiological and physiopathological changes of circadian rhythmicity, nocturnal symptoms and overnight decrements in lung functions are a common part of the asthma clinical syndrome [9]. Circadian changes are seen in normal lung function, which reaches a low point in the early morning hours.…”

On distance dependent entropy measures of poly propylene imine and zinc porphyrin dendrimers

“…More specifically, the shape of porphyrin-based nanotubes was optimized and electronic characteristics for the porphyrin sheet and all other porphyrin-based nanotube were determined. In [34], several features for characterizing dendrimers were reviewed, which also include porphyrin-based dendrimers.…”