A review on protective role of genistein against oxidative stress in diabetes and related complications

Weng, Lihong; Zhang, Fengying; Wang, Rui; Ma, Wei; Song, Yingshi

doi:10.1016/j.cbi.2019.05.031

Cited by 50 publications

(30 citation statements)

References 89 publications

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“…Genistein is well known for its anti-inflammatory [21][22][23], anti-diabetic [24,25], and anti-cancer [26,27] activities. In a recent study, Kim, Dong Hwan et al reported the potential anti-allergic and anti-inflammatory activity of Genistein on mast cells via inhibiting cytokines and the ERK pathway [30].…”

Section: Discussionmentioning

confidence: 99%

“…Genistein is a non-steroidal polyphenol that possesses diverse pharmacological activities. There is evidence for the protective effects of Genistein in inflammation [21][22][23], diabetes [24,25], cancer [26,27] and hypersensitivity reactions [28,29]. In a recent paper, Kim, Dong Hwan et al reported the anti-inflammatory activity of Genistein on mast cells via inhibiting cytokines and the ERK pathway and proposed potential of Genistein for the treatment of allergic inflammation and anaphylactic shock [30].…”

Section: Introductionmentioning

confidence: 99%

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Protective Effect of Genistein against Compound 48/80 Induced Anaphylactoid Shock via Inhibiting MAS Related G Protein-Coupled Receptor X2 (MRGPRX2)

et al. 2020

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Anaphylactoid shock is a fatal hypersensitivity response caused by non-IgE mediated mast cell activation. These reactions are mediated by a family of G protein-coupled receptors (GPCRs) known as Mas related GPCRX2 (MRGPRX2). Several US FDA approved drugs which are used in day to day life have been reported to cause anaphylactoid shock. Surprisingly, no therapeutic drugs are available which can directly target MRGPRX2 for treatment of anaphylactoid shock. Genistein is a non-steroidal polyphenol known for its diverse physiological and pharmacological activities. In recent studies, Genistein has been reported for its anti-inflammatory activity on mast cells. However, the effects and mechanistic pathways of Genistein on anaphylactoid reaction remain unknown. In the present study, we designed a battery of in-vitro, in-silico and in-vivo experiments to evaluate the anti-anaphylactoid activity of Genistein in order to understand the possible molecular mechanisms of its action. The in-vitro results demonstrated the inhibitory activity of Genistein on MRGPRX2 activation. Further, a mouse model of anaphylactoid shock was used to evaluate the inhibitory activity of Genistein on blood vessel leakage and hind paw edema. Taken together, our findings have demonstrated a therapeutic potential of Genistein as a lead compound in the treatment of anaphylactoid shock via MRGPRX2.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Protective Effect of Genistein against Compound 48/80 Induced Anaphylactoid Shock via Inhibiting MAS Related G Protein-Coupled Receptor X2 (MRGPRX2)

et al. 2020

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“…Moreover, puerarin ameliorates diabetic complications, such as cardiovascular complications, diabetic nephropathy, retinopathy, neuropathy, and so on. Genistein benefits type 2 diabetes via remarkably ameliorating hyperglycemia (Fu et al., 2012; Rockwood et al., 2019), enhancing β‐cell proliferation and reducing apoptosis (Gilbert & Liu, 2013), ameliorating cardiac inflammation and oxidative stress (Gupta et al., 2015), improving fracture resistance (Odle, Dennison, Al‐Nakkash, Broderick, & Plochocki, 2017), ameliorating vascular dysfunction (Valsecchi et al., 2011), and alleviating diabetic neuropathy, nephropathy, and retinopathy (Weng, Zhang, Wang, Ma, & Song, 2019).…”

Section: Mechanisms Of Dietary Polyphenols As Antidiabetic Agentsmentioning

confidence: 99%

Dietary polyphenols as antidiabetic agents: Advances and opportunities

et al. 2020

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Dietary polyphenols have been widely investigated as antidiabetic agents in cell, animals, human study, and clinical trial. The number of publication (Indexed by Web of Science) on "polyphenols and diabetes" significantly increased since 2010. This review highlights the advances and opportunities of dietary polyphenols as antidiabetic agents.Dietary polyphenols prevent and manage Type 2 diabetes mellitus via the insulindependent approaches, for instance, protection of pancreatic islet -cell, reduction of -cell apoptosis, promotion of -cell proliferation, attenuation of oxidative stress, activation of insulin signaling, and stimulation of pancreas to secrete insulin, as well as the This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. c ○ 2020 The Authors. Food Frontiers published

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“…In vitro mammalian studies have shown that GE impairs adipocyte differentiation in the 3T3-L1 cell line, leading to apoptosis of mature adipocytes [17], and reduces lipid accumulation in a dose-dependent manner in primary human preadipocytes, showing the cells exposed to high doses of GE a fibroblast-like morphology instead of the characteristic round shape of mature adipocytes [18]. Regarding in vivo assays, GE is generally considered hypolipidemic [19], but differences have been shown depending on its content in the diet. A reduction in adipose tissue mass has also been reported in several in vivo mice models with GE stimulating lipolysis and adipocytes apoptosis at the same time (reviewed in [14]), while in human visceral preadipocytes, GE has been demonstrated to promote adipogenesis [20].…”

Section: Introductionmentioning

confidence: 99%

Genistein Induces Adipogenic and Autophagic Effects in Rainbow Trout (Oncorhynchus mykiss) Adipose Tissue: In Vitro and In Vivo Models

Balbuena-Pecino

Lutfi

Riera‐Heredia

et al. 2020

IJMS

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Soybeans are one of the most used alternative dietary ingredients in aquafeeds. However, they contain phytoestrogens like genistein (GE), which can have an impact on fish metabolism and health. This study aimed to investigate the in vitro and in vivo effects of GE on lipid metabolism, apoptosis, and autophagy in rainbow trout (Oncorhynchus mykiss). Primary cultured preadipocytes were incubated with GE at different concentrations, 10 or 100 μM, and 1 μM 17β-estradiol (E2). Furthermore, juveniles received an intraperitoneal injection of GE at 5 or 50 µg/g body weight, or E2 at 5 µg/g. In vitro, GE 100 μM increased lipid accumulation and reduced cell viability, apparently involving an autophagic process, indicated by the higher LC3-II protein levels, and higher lc3b and cathepsin d transcript levels achieved after GE 10 μM. In vivo, GE 50 µg/g upregulated the gene expression of fatty acid synthase (fas) and glyceraldehyde-3-phosphate dehydrogenase in adipose tissue, suggesting enhanced lipogenesis, whereas it increased hormone-sensitive lipase in liver, indicating a lipolytic response. Besides, autophagy-related genes increased in the tissues analyzed mainly after GE 50 µg/g treatment. Overall, these findings suggest that an elevated GE administration could lead to impaired adipocyte viability and lipid metabolism dysregulation in rainbow trout.

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A review on protective role of genistein against oxidative stress in diabetes and related complications

Cited by 50 publications

References 89 publications

Protective Effect of Genistein against Compound 48/80 Induced Anaphylactoid Shock via Inhibiting MAS Related G Protein-Coupled Receptor X2 (MRGPRX2)

Protective Effect of Genistein against Compound 48/80 Induced Anaphylactoid Shock via Inhibiting MAS Related G Protein-Coupled Receptor X2 (MRGPRX2)

Dietary polyphenols as antidiabetic agents: Advances and opportunities

Genistein Induces Adipogenic and Autophagic Effects in Rainbow Trout (Oncorhynchus mykiss) Adipose Tissue: In Vitro and In Vivo Models

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