A Review on Proniosomes: A Propitious Outlook to the Provesicular Drug
Delivery System

Apurvi, Pragya; Saxena, Anamika; Aslam, Ramsha

doi:10.2174/1567201820666221019093921

Cited by 2 publications

(3 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One such system that contributes to extending the duration of a drug in systemic circulation and reducing toxicity through selective uptake is drug encapsulation in vesicles. This method has led to the developing of several vesicular drug delivery systems, including liposomes, niosomes, and provesicular systems like proliposomes and proniosomes [1]. Even though the oral route of drug administration has advantages, researchers are constantly looking for newer approaches because they are aware of the major roles that poor drug solubility and absorption, rapid metabolism, high fluctuations in drug plasma, and variability due to food effect play in disappointing in vivo results that ultimately cause the conventional delivery system to fail [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…Due to many new chemical entities (NCEs) and poor water solubility, which impairs therapeutic absorption, effective drug administration is essential [1,3,5]. Low solubility, enzyme breakdown, and acidic stomach conditions are among the difficulties associated with oral delivery [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…Colloidal lipid carriers have been used as treatment, improving drug solubility and gastrointestinal barrier permeability [4][5][6]. Designing proniosome-like vesicular drug delivery devices shows potential [1,2]. Due to its limited solubility and promise for increased oral administration, extended-release, and improved patient compliance, testosterone undecanoate was chosen for proniosome manufacture.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Fabrication, ‘Optimisation,’ Characterization, and In Vivo Pharmacokinetic Evaluation of Testosterone Undecanoate Loaded Proniosome Capsule for Enhanced Oral Bioavailability

Singh,

Soni,

Kumari

2024

ASEAN Sci Tech Rept

View full text Add to dashboard Cite

This study focuses on creating and evaluating proniosome capsules as a potential drug delivery method to increase the oral bioavailability of testosterone undecanoate. The three main stages of the study are proniosome capsule fabrication optimization, characterization, and in vivo pharmacokinetic evaluation. The most prominent response surface approach (CCD – Central Composite Design) was used in the fabrication-optimization phase to determine the appropriate ratios of the factors that have the greatest effects on the particle size, PDI, and percentage of drug entrapment of testosterone undecanoate proniosomes. Creating testosterone undecanoate-loaded proniosomal formulations was possible using various ratios of span 60 and cholesterol. The physical and chemical characteristics of proniosome capsules, such as size, shape, surface charge, and drug-release kinetics, such as percentage drug entrapment, Vesicle size (nm), and PDI, must be thoroughly analyzed. Animal models were used to determine how the proniosome capsules affect the bioavailability of testosterone undecanoate after oral administration. Factors like absorption, distribution, metabolism, and excretion are carefully evaluated to determine whether the capsules successfully enhance drug delivery. The reduced particle size, polydispersity index (PDI, 282.33 ± 1.52 nm and 0.181 ± 0.003), and the highest entrapment efficiency (98.12 ± 1.03%) made the optimized formulation the ideal formulation. The Higuchi model provided the most comprehensive justification for releasing the testosterone undecanoate from proniosome compositions. Up to six months of storage, no changes of any type, even those to the proniosomes' color, were seen. There was no drug leakage during the stability study, according to the percentage of drug entrapment data. Positive findings from the in vivo pharmacokinetic investigation also suggested that testosterone undecanoate proniosome formulations may last significantly longer than a pure drug in vivo.

show abstract

Section: Introductionmentioning

confidence: 99%