A Review on Polymeric Membranes and Hydrogels Prepared by Vapor-Induced Phase Separation Process

Venault, Antoine; Chang, Yung; Wang, Da-Ming; Bouyer, Denis

doi:10.1080/15583724.2013.828750

Cited by 86 publications

(58 citation statements)

References 94 publications

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“…RH has a decisive effect on the number and size of pores as it results in different composition paths as shown in the ternary phase diagram ( Figure 1B). 25 Among the various process parameters in designing VIPS-based membranes, 26 in this study, the pore size of the NTHP membrane was tuned by controlling the RH, spin-rate, and different types of solvent in polymer solution. NTHP membranes with distinctively different sizes of well-defined pores (i.e., an average of 100, 380, …”

Section: Resultsmentioning

confidence: 99%

Nanothin Coculture Membranes with Tunable Pore Architecture and Thermoresponsive Functionality for Transfer-Printable Stem Cell-Derived Cardiac Sheets

Ryu¹,

Yoo²,

Jang³

et al. 2015

ACS Nano

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Coculturing stem cells with the desired cell type is an effective method to promote the differentiation of stem cells. The features of the membrane used for coculturing are crucial to achieving the best outcome. Not only should the membrane act as a physical barrier that prevents the mixing of the cocultured cell populations, but it should also allow effective interactions between the cells. Unfortunately, conventional membranes used for coculture do not sufficiently meet these requirements. In addition, cell harvesting using proteolytic enzymes following coculture impairs cell viability and the extracellular matrix (ECM) produced by the cultured cells. To overcome these limitations, we developed nanothin and highly porous (NTHP) membranes, which are ∼20-fold thinner and ∼25-fold more porous than the conventional coculture membranes. The tunable pore size of NTHP membranes at the nanoscale level was found crucial for the formation of direct gap junctions-mediated contacts between the cocultured cells. Differentiation of the cocultured stem cells was dramatically enhanced with the pore size-customized NTHP membrane system compared to conventional coculture methods. This was likely due to effective physical contacts between the cocultured cells and the fast diffusion of bioactive molecules across the membrane. Also, the thermoresponsive functionality of the NTHP membranes enabled the efficient generation of homogeneous, ECM-preserved, highly viable, and transfer-printable sheets of cardiomyogenically differentiated cells. The coculture platform developed in this study would be effective for producing various types of therapeutic multilayered cell sheets that can be differentiated from stem cells.

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Section: Resultsmentioning

confidence: 99%

Nanothin Coculture Membranes with Tunable Pore Architecture and Thermoresponsive Functionality for Transfer-Printable Stem Cell-Derived Cardiac Sheets

Ryu¹,

Yoo²,

Jang³

et al. 2015

ACS Nano

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“…As discussed earlier, when the porosity was decreased at a higher polymer concentration, the contact angle should have been lower. However, it seemed that the membrane with a lower porosity gave a higher contact angle . In this case, the only probable explanation was the changes in polymer crystallinity.…”

Section: Resultsmentioning

confidence: 95%

Nodular structure and crystallinity of poly(vinylidene fluoride) membranes: Impact on the performance of direct‐contact membrane distillation for nutrient isolation

Yatim

Karim

Ooi

2018

J of Applied Polymer Sci

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The main objective of this study was to prepare a low‐surface‐energy poly(vinylidene fluoride) (PVDF) membrane distillation via changes in its surface morphology and crystallinity. We found that membranes prepared at different polymer concentrations with a dual coagulation bath showed distinctive differences in terms of their physical and chemical properties. We found that when the polymer concentration was increased, both the pore sizes and porosities of the membranes decreased. In addition, the polymer concentration also resulted in significant changes to the surface roughness and morphology of the membrane, which were manifested through varied nodule shapes and sizes. Higher polymer concentrations gave better wetting resistance (higher liquid entry pressure) because of the increasing hydrophobic α‐phase crystallinity but suffered from a lower porosity (lower vapor permeability). At a higher PVDF concentration, we expected that the thermal efficiency would be lower (because of the lower porosity); however, we observed an appreciable contrast phenomenon due to the increasing nonconductive α‐phase, and this lowered the thermal conductivity. These observations showed that the wettability of the membrane very much depended on the chemical properties of PVDF. The optimum membrane (20% PVDF) showed a consistent nutrient rejection of more than 99% with a membrane flux of 9.491 kg m2 h ± 0.1 at a feed temperature of 90 °C. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46866.

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“…1,2 Conventional hydrogels are composed of hydrophilic polymer networks bridged through van der Waals interactions, hydrogen bonds, or physical bonds that form 3-dimensional polymer networks. These 3-dimensional hydrophilic hydrogels with semisolid morphology can also be prepared through chemical or physical cross-linkings.…”

Section: Introductionmentioning

confidence: 99%

Stimuli-Responsive InjectableIn situ-Forming Hydrogels for Regenerative Medicines

Kim

Kwon

et al. 2015

Polymer Reviews

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Research on injectable in situ-forming hydrogels has been conducted in diverse biomedical applications for a long period. These hydrogels exhibit sol-to-gel phase transition in accordance with the external stimuli such as temperature change. Also, unlike the traditional surgical procedures the hydrogels have the distinct properties of easy management and minimal invasiveness via simple aqueous state injections at target sites. Currently, numerous polymer materials have been reported as potential stimulusinduced in situ-forming hydrogels. In this review, a comprehensive overview of the state-of-the-art of these rapidly developing materials has been outlined. In situ-forming hydrogels formed by electrostatic and hydrophobic interactions as well as their mechanistic characteristics and biomedical applications in regenerative medicine have also been discussed. The review concludes with perspectives on the future of stimulus-induced in situ-forming hydrogels.

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A Review on Polymeric Membranes and Hydrogels Prepared by Vapor-Induced Phase Separation Process

Cited by 86 publications

References 94 publications

Nanothin Coculture Membranes with Tunable Pore Architecture and Thermoresponsive Functionality for Transfer-Printable Stem Cell-Derived Cardiac Sheets

Nanothin Coculture Membranes with Tunable Pore Architecture and Thermoresponsive Functionality for Transfer-Printable Stem Cell-Derived Cardiac Sheets

Nodular structure and crystallinity of poly(vinylidene fluoride) membranes: Impact on the performance of direct‐contact membrane distillation for nutrient isolation

Stimuli-Responsive InjectableIn situ-Forming Hydrogels for Regenerative Medicines

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