A review on pharmacological activities and anti-microbial properties of <em>Nigella sativa</em> and isolated Thymoquinone

Abstract

Nigella sativa has been marked as precious medicinal herb consisting various bioactive compounds including Thymoquinone and very strengthen evidences can be found in literature in this regard. Nigella sativa has popularized as a miracle medicinal herb against pathogenic microorganisms including human infected deleterious viral species such as Human Immunodeficiency Virus (HIV) and Hepatitis C Virus (HCV). Recent animal studies have proved that, Nigella sativa seed extract can apply against virus species including Murine Cytomegalovirus (MCMV), Papaya Ring Spot Virus, Avian influenza (H9N2), Newcastle disease virus (NDV), Peste des Petits Ruminants (PPR) Virus. It is important to focus on Thymoquinone as main bioactive compound of the Nigella sativa. Among them, anti-cancer effect, cardiovascular effects, gastro-protective effect, anti-diabetic activity and free radicle scavenging activities are the most beneficial effects revealed in recent research studies. Hence, more discreet investigations required for the pharmacological actions of bioactive compounds of the Nigella sativa specially for the drug development.

Medicinal plants and functional foods sold by market vendors and used by their clients for COVID-19 in Gondar City, Ethiopia

“…Eucalyptus essential oil is particularly promising in the management of cough and inflammation caused by SARS-CoV-2 and influenza viruses because of its anti-inflammatory, mucolytic, and spasmolytic effects [51]. Black cumin seeds, sold by 36 (94.7%) vendors, have been found to have anti-viral activity against the human immunodeficiency virus, hepatitis C, HIV, avian influenza (H9N2), and murine cytomegalovirus [52].…”

Protective potential of thymoquinone against cadmium, arsenic, and lead toxicity: A short review with emphasis on oxidative pathways

“…Among these, the keto form is the main fraction (about 90%) and is responsible for the pharmacological features of this bioactive agent (Ahmad et al, 2019; Darakhshan et al, 2015). TQ has proven to possess anti‐inflammatory (Shaterzadeh‐Yazdi et al, 2018), anti‐microbial (Khan, 2018; Perera et al, 2021), anti‐histaminic, hypolipidemic (Ahmad & Beg, 2013b), and antioxidant properties (Cobourne‐Duval et al, 2016; Guan et al, 2018; Zeinvand‐Lorestani et al, 2018) that could be of effective therapeutic effects in the prevention/treatment of different diseases such as diabetes (El‐Aarag et al, 2017; Farkhondeh et al, 2017), various cancers (Almatroodi et al, 2020; Imran et al, 2018; Junaid et al, 2021; Mahmoud & Abdelrazek, 2019; Majdalawieh et al, 2017), cardiovascular disorders (Ahmad & Beg, 2013a; Xu et al, 2018), and neurodegenerative disease (Farkhondeh et al, 2018; Samarghandian et al, 2018).…”

Profiles of Fatty Acids, Polyphenols, Sterols, and Tocopherols and Scavenging Property of Mediterranean Oils: New Sources of Dietary Nutrients for the Prevention of Age-related Diseases

“…The higher antioxidant activity of NSO, compared to the other studied oils, could be attributed to its richness in thymoquinone (1.2 mg EQ/100 g) . In fact, this chemical component is recognized as the main bioactive compound of the Nigella sativa endowed with a strong antioxidant activity 90) .…”