Colorectal disease is the third most prevelant cancer in both men and women, with an
expected 106,180 new cases of colon cancer and 44,850 new cases of rectal cancer as per American
Cancer Society. Targeted medicine delivery is vital in the treatment of colon disorders because it
delivers long-term therapeutic results with little side effects. Natural polymer is biocompatible and
biodegradable, which enables safety, improves storage, and physiological stability, it is utilized as
drug delivery vehicles and has made great strides in recent years. Chitosan, alginate, pectin, guar
gum, dextran, hyaluronic acid, and arabinoxylan are examples of natural polysaccharides that are
utilized to create nanoparticles. Natural gums serve two purposes: first, they shield the medicine
from stomach and intestinal conditions, allowing it to only be released in the colon. In this review,
we introduce the different gum particularly used in nanoparticles formulation, and then discuss recent
research and the latest patent in the development of gum-based nanoparticles for the treatment
of colon rectal cancer.