A Review on Medicinal Uses, Nutritional Value, and Antimicrobial, Antioxidant, Anti-Inflammatory, Antidiabetic, and Anticancer Potential Related to Bioactive Compounds of
            <i>J. regia</i>

Bourais, Ilhame; Elmarrkechy, Salma; Taha, Douae; Mourabit, Yassine; Bouyahya, Abdelhakim; Yadini, Meryem El; Machich, Omar; Hajjaji, Souad El; Boury, Houria El; Dakka, Nadia; Iba, Naima

doi:10.1080/87559129.2022.2094401

Cited by 33 publications

(18 citation statements)

References 97 publications

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“…Furthermore, Juglans regia has antimicrobial ( Staphylococcus aureus and Klebsiella pneumonia) , antioxidant, anti-inflammatory, anti-diabetic and it has anticancer activity proven against colon adenocarcinoma, breast adenocarcinoma, glioblastoma, astrocytoma, and melanoma cell lines. It is due to the fact that it contains several secondary metabolites, such as polyphenols, flavonoids, and glycosides [ 37 , 38 ]. On the other hand, Rumex pulcher has a folic acid level above 100% of the recommended daily intake.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Monitoring of the Traditional Knowledge of Plant Species Used for Culinary Purposes in the Valencia Region, South-Eastern Spain

Belda,

Jordán-Nuñez,

Micó-Vicent

et al. 2024

Plants

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The aim of this study is to inventory and study ethnobotanical knowledge of edible plants in the Valencian Community (Spain). In respect to culinary uses, 92 species of plant were reported to be edible, finding the following uses: 58 raw, 52 cooked, 16 fried, 7 dried, 21 in liquors and beverages, 25 in dessert and sweets, 11 as seasoning, 17 in pickles, and 10 to curdle milk. We prepared a database that includes genus, family, scientific, and vernacular names in Spanish and Catalan for each plant. We also created a classification of nine edible uses and plant parts used, being Asteraceae (n = 18), Brassicaceae (n = 7), Chenopodiaceae (n = 6), and Rosaceae (n = 6) the families most characterized for gastronomic purposes. The species with the most elevated cultural importance (CI) values were Foeniculum vulgare (CI = 1.389), Cynara scolymus (CI = 1.374), Papaver rhoeas (CI = 1.211), Beta vulgaris (CI = 1.167), and Juglans regia (CI = 1.155). The most used parts were the leaves (71), flowers (25), and branches (19), while the least used were roots (9) and seeds (8). Traditional knowledge of these plants helps to preserve traditional cuisine, promote the local economy and, in several species, encourage their cultivation.

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Section: Discussionmentioning

confidence: 99%

Long-Term Monitoring of the Traditional Knowledge of Plant Species Used for Culinary Purposes in the Valencia Region, South-Eastern Spain

Belda,

Jordán-Nuñez,

Micó-Vicent

et al. 2024

Plants

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“…Flavonoids are a class of phenolic chemicals found in plants, fruits, and vegetables and are distinguished by a carbon skeleton base of C6-C3-C6. Having already been identified as antioxidant, antidiabetic, anti-inflammatory, antibacterial, antiviral, and antitumor agents, this group of phytochemicals is commonly consumed in human diet and has attracted significant scientific interest [11][12][13][14]. Epigallocatechin-3-gallate, apigenin, genistein, luteolin, quercetin, silibinin, kaempferol, and naringenin have been reported as effective flavonoid-based anticancer therapies in recent years [15].…”

Section: Introductionmentioning

confidence: 99%

Targeting Wnt/β-Catenin Pathway by Flavonoids: Implication for Cancer Therapeutics

et al. 2023

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The Wnt pathway has been recognized for its crucial role in human development and homeostasis, but its dysregulation has also been linked to several disorders, including cancer. Wnt signaling is crucial for the development and metastasis of several kinds of cancer. Moreover, members of the Wnt pathway have been proven to be effective biomarkers and promising cancer therapeutic targets. Abnormal stimulation of the Wnt signaling pathway has been linked to the initiation and advancement of cancer in both clinical research and in vitro investigations. A reduction in cancer incidence rate and an improvement in survival may result from targeting the Wnt/β-catenin pathway. As a result, blocking this pathway has been the focus of cancer research, and several candidates that can be targeted are currently being developed. Flavonoids derived from plants exhibit growth inhibitory, apoptotic, anti-angiogenic, and anti-migratory effects against various malignancies. Moreover, flavonoids influence different signaling pathways, including Wnt, to exert their anticancer effects. In this review, we comprehensively evaluate the influence of flavonoids on cancer development and metastasis by focusing on the Wnt/β-catenin signaling pathway, and we provide evidence of their impact on a number of molecular targets. Overall, this review will enhance our understanding of these natural products as Wnt pathway modulators.

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“…In fact, walnuts (Juglans regia) are a great source of unsaturated fatty acids [23][24][25] , fiber, minerals (potassium, calcium, and magnesium) [26,27] , amino acids and proteins [28,29] , phenolic compounds and saponins [30][31][32] , as well as a variety of other compounds that make J. regia has a vast diversity of medicinal properties [33] . In addition, the phytochemicals present in plants like J. regia have been shown to have therapeutic effects, including anticancer, anti-inflammatory, and anti-bacterial properties [34] .…”

Section: Introductionmentioning

confidence: 99%

Bioactivity of Walnut: Investigating the Triterpenoid Saponin Extracts of Juglans regia Kernels for Antioxidant, Anti-diabetic, and Antimicrobial Properties

Elouafy¹,

Mortada²,

Yadini³

et al. 2023

Prog Micobes Mol Biol

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The increasing demand for plant-based medicines makes plant research attractive to find natural alternatives that can replace synthetic products or at least reduce their use. Saponins are a group of natural phytochemical compounds in most herbs, vegetables, and legumes. There are two different types of saponin compounds, which can be classified based on the nature of the aglycone bound to the oligosaccharide fragments, whether it is a steroid or triterpenoid. This paper is devoted to saponins with triterpenoid aglycone and aims to study the relationship between their content and several biological activities in different Juglans regia kernel extracts, including antioxidant, antimicrobial and antibacterial activities. Antioxidant activity was assessed against two free radicals: DPPH and ABTS. Oleanolic acid was used as a standard to quantify triterpenoid saponins, measured by the vanillin method, whereas Acarbose and Tetracycline were used as positive controls to evaluate the α-glucosidase inhibitory and antimicrobial activities, respectively, of walnut kernel extracts. Findings show that hydroalcoholic extract (EtOH 70%) has a considerable content of phenolic compounds, with 59.51 ± 0.26 mg GAE/g in total polyphenol contents, while the content of total flavonoids and condensed tannins were 3.14 ± 0.27 mg QE/g and 85.65 ± 0.37 mg CE/g of crude extract, respectively. In terms of antioxidant activity, the butanolic extract proved to be the most effective against DPPH with IC50 = 7.74 ± 1.49 µg/mL, while the precipitated extract showed the highest scavenging activity against the ABTS free radical with IC50 = 33.14 ± 2.96 µg/mL. In addition, butanolic and hydroalcoholic extracts of Juglans regia kernels showed an α-glucosidase inhibitory activity even more efficiently than synthetic drugs such as Acarbose, with IC50 values of 11.66 µg/mL and 16.17 µg/mL, respectively, versus 18.01 µg/mL in Acarbose. The evaluation of the antimicrobial activity against Bacillus subtilis, Escherichia coli and Klebsiella pneumonia strains revealed that some extracts could inhibit these bacteria. This study successfully assessed the bioactivities of the extracts, suggesting that the extracts of medicinal plants can demonstrate stronger bioactivity than pure synthetic compounds.

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A Review on Medicinal Uses, Nutritional Value, and Antimicrobial, Antioxidant, Anti-Inflammatory, Antidiabetic, and Anticancer Potential Related to Bioactive Compounds of J. regia

Cited by 33 publications

References 97 publications

Long-Term Monitoring of the Traditional Knowledge of Plant Species Used for Culinary Purposes in the Valencia Region, South-Eastern Spain

Long-Term Monitoring of the Traditional Knowledge of Plant Species Used for Culinary Purposes in the Valencia Region, South-Eastern Spain

Targeting Wnt/β-Catenin Pathway by Flavonoids: Implication for Cancer Therapeutics

Bioactivity of Walnut: Investigating the Triterpenoid Saponin Extracts of Juglans regia Kernels for Antioxidant, Anti-diabetic, and Antimicrobial Properties

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