A review on grafting of hydroxyethylcellulose for versatile applications

Noreen, Aqdas; Zia, Khalid Mahmood; Tabasum, Shazia; Khalid, Sana; Shareef, Rahila

doi:10.1016/j.ijbiomac.2020.01.265

Cited by 46 publications

(20 citation statements)

References 162 publications

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“…HEC is a low-cost polymer with an attractive nonionic, water-soluble, biocompatible, biodegradable, nontoxic, and highly polar polymer due to its high content of hydroxyl groups. 34,35 HEC is mainly hydrophilic, but some authors identified that hydrophobic groups on HEC chain represent areas of high affinity when they are mixed with some surfactant. SDS is an anionic and amphiphilic surfactant used in polystyrene latex with HEC with an adsorption surface capability.…”

Section: Introductionmentioning

confidence: 99%

Colloidal and rheological properties of natural rubber latex concentrated with hydroxyethyl cellulose and sodium dodecyl sulphate

Walteros‐León

Álvarez-Láinez

2021

J of Applied Polymer Sci

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Natural rubber latex (NRL) is a complex colloidal system composed of rubber particles surrounded by a layer of phospholipids and proteins maintaining its colloidal stability. NRL creaming is a nonrobust concentration method, and its colloidal and rheological properties can be altered due to the presence of creaming agents and surfactants. Both properties must remain stable over time after creaming to ensure conditions for subsequent manufacturing processes.These properties have been evaluated for synthetic latex, but not for NRL in which the clone variety and phenological factors make the system being always different. In this research, hydroxyethyl cellulose (HEC) and sodium dodecyl sulphate (SDS) are used to concentrate NRL and response surface methodology was selected to optimize the colloidal and rheological properties of creamed NRL. Flocculation and stabilization by depletion are involved on NRL concentration depending on HEC and SDS concentration. Those agents modify NRL zeta potential in a range of À78 and À63 mV, and viscosity increases more than 10 times the raw NRL value. SDS plays a key role on enhancement of the creaming process and in electrostatic stability because its anionic nature. Physicochemical interactions between NRL, HEC, and SDS are proposed.

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Section: Introductionmentioning

confidence: 99%

Colloidal and rheological properties of natural rubber latex concentrated with hydroxyethyl cellulose and sodium dodecyl sulphate

Walteros‐León

Álvarez-Láinez

2021

J of Applied Polymer Sci

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“…Other water-soluble polymers like hydroxyethyl cellulose (HEC) are used in the biomedical arena, paint industry, soil amendments (they improve permeability and water retention) in agriculture, coal dewatering, cosmetics, wastewater treatment, absorbent pads and gel electrolyte membranes (they have good thermal stability, good cycling stability and high capacity retention). Moreover, water-soluble polymers could be made as a compound and grafted with other polymers to modify their physical/chemical/biological properties, e.g., combining hydrophilic and hydrophobic polymers for controlled drug release, for example grafting HEC with polylactic acid to functionalise the main polymer chain to alter the properties [ 35 , 36 , 37 ].…”

Section: Resultsmentioning

confidence: 99%

Generation of Core–Sheath Polymer Nanofibers by Pressurised Gyration

et al. 2020

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The ability to generate core–sheath bicomponent polymer nanofibers in a single-step with scale-up possibilities is demonstrated using pressurised gyration manufacturing. This is the first time that nanofiber containing more than one polymer having a core–sheath configuration has been generated in this way. Water-soluble polymers polyethylene oxide (PEO) and polyvinyl pyrrolidone (PVP) are used as the core and sheath layers, respectively. Core–sheath nanofibers with a diameter in the range of 331 to 998 nm were spun using 15 wt % PEO and 15 wt % PVP polymer solutions. The forming parameters, working pressure and rotating speed, had a significant influence on the size, size distribution and the surface morphology of the nanofibers generated. Overall, fibre size decreased with increasing working pressure and rotating speed. The fibre size was normally distributed in all cases, with 0.2 MPa working pressure in particular showing narrower distribution. The fibre size distributions for 0.1 and 0.3 MPa working pressure were broader and a mean fibre size of 331 nm was obtained in the latter case. The fibre size was evenly distributed and narrower for rotating speeds of 2000 and 4000 RPMs. The distribution was broader for rotating speed of 6000 RPM with a mean value obtained at 430 nm. Continuous, smooth and bead-free fibre morphologies were obtained in each case. The fibre cross-section analysis using a focused ion beam machine showed a solid core surrounded by a sheath layer. Our findings demonstrate that the pressurised gyration could be used to produce core–sheath polymer nanofibers reliably and cost-effectively with scale-up possibilities (~4 kg h−1).

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“…It is a biocompatible, biodegradable, hydrophilic, nonionic water-soluble, low toxic, and non-immunogenic cellulose derivative [128] (Table 10). HEC can be used as a stabilizer, thickener, or coating material, and because of the high aqueous solubility, HEC can be used in various applications that as film-forming materials, in pharmaceuticals, in cosmetics, biotechnology, and in ophthalmic preparations [221][222][223]. France et al studied the sustained release of dorzolamide (hydrophilic drug) as an anti-glaucomic agent that is an ocular insert that can decrease the dose frequency, low systemic exposure, decrease the adverse effect, and improve patient compliance.…”

Section: Dexamethasonementioning

confidence: 99%

Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems

et al. 2021

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One of the major impediments to drug development is low aqueous solubility and thus poor bioavailability, which leads to insufficient clinical utility. Around 70–80% of drugs in the discovery pipeline are suffering from poor aqueous solubility and poor bioavailability, which is a major challenge when one has to develop an ocular drug delivery system. The outer lipid layer, pre-corneal, dynamic, and static ocular barriers limit drug availability to the targeted ocular tissues. Biopharmaceutical Classification System (BCS) class II drugs with adequate permeability and limited or no aqueous solubility have been extensively studied for various polymer-based solubility enhancement approaches. The hydrophilic nature of cellulosic polymers and their tunable properties make them the polymers of choice in various solubility-enhancement techniques. This review focuses on various cellulose derivatives, specifically, their role, current status and novel modified cellulosic polymers for enhancing the bioavailability of BCS class II drugs in ocular drug delivery systems.

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A review on grafting of hydroxyethylcellulose for versatile applications

Cited by 46 publications

References 162 publications

Colloidal and rheological properties of natural rubber latex concentrated with hydroxyethyl cellulose and sodium dodecyl sulphate

Colloidal and rheological properties of natural rubber latex concentrated with hydroxyethyl cellulose and sodium dodecyl sulphate

Generation of Core–Sheath Polymer Nanofibers by Pressurised Gyration

Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems

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