A review on gentisic acid as a plant derived phenolic acid and metabolite of aspirin: Comprehensive pharmacology, toxicology, and some pharmaceutical aspects

Abedi, Farshad; Razavi, Bibi Marjan; Hosseinzadeh, Hossein

doi:10.1002/ptr.6573

Cited by 101 publications

(52 citation statements)

References 74 publications

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“…Naringin is a major compound extracted from tomatoes, grapefruits, and related citrus fruits [10]. It exhibits potential protective effects against atherosclerosis development [11,12]. Pharmacological investigations have shown that naringin has anti-inflammatory, anti-oxidant, anti-apoptotic, and hepato-protective effects [13,14].…”

Section: Introductionmentioning

confidence: 99%

Naringin protects endothelial cells from apoptosis and inflammation by regulating the Hippo-YAP Pathway

Zhao

Liu

et al. 2020

Bioscience Reports

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Atherosclerosis is the primary cause of several cardiovascular diseases. Oxidized low-density lipoprotein (ox-LDL)-induced apoptosis, endothelial–mesenchymal transition (EndMT), and inflammation are crucial for the progression of cardiovascular diseases, including atherosclerosis. Naringin, a major compound from tomatoes, grapefruits, and related citrus, reportedly exhibits potential protective effects during atherosclerosis development; however, its effect on ox-LDL-induced human umbilical vein endothelial cell (HUVEC) damage remains unknown. In the present study, we investigated the anti-apoptotic and anti-inflammatory activities of naringin against ox-LDL-induced endothelial cells, and the underlying mechanism. Naringin pretreatment significantly and concentration-dependently inhibited ox-LDL-induced cell injury and apoptosis. Additionally, naringin restored endothelial barrier integrity by preventing VE-cadherin disassembly and F-actin remodeling, and down-regulated pro-inflammatory factors like IL-1β, IL-6, and IL-18, in the HUVECs. We also demonstrated that naringin treatment restored ox-LDL-induced YAP (yes-associated protein) down-regulation, given the YAP-shRNA attenuated cytoprotective effect of naringin on ox-LDL-induced endothelial cell injury and apoptosis. Collectively, our data indicate that naringin reversed ox-LDL-triggered HUVEC apoptosis, EndMT, and inflammation by inhibiting the YAP pathway. Therefore, naringin may have a therapeutic effect on endothelial injury-related disorders.

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Section: Introductionmentioning

confidence: 99%

Naringin protects endothelial cells from apoptosis and inflammation by regulating the Hippo-YAP Pathway

Zhao

Liu

et al. 2020

Bioscience Reports

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“…Over the years, the antimicrobial properties of some phenolic compounds, namely protocatechuic acid [ 76 ], gentisic acid [ 77 ], catechin and epicatechin [ 78 ], and other flavonoids [ 36 , 79 , 80 , 81 , 82 , 83 ] were reported. A high amount of these phenolic compounds in plants can lead to a more effective response in defense against pathogens [ 36 , 79 , 80 , 81 , 82 , 83 ].…”

Section: Resultsmentioning

confidence: 99%

Ayahuasca Beverages: Phytochemical Analysis and Biological Properties

et al. 2020

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Ayahuasca is a psychoactive beverage, originally consumed by indigenous Amazon tribes, of which consumption has been increasing worldwide. The aim of this study was to evaluate the phytochemical profile, as well as the antioxidant, anti-inflammatory and antimicrobial properties of decoctions of four individual plants, a commercial mixture and four mixtures of two individual plants used in the Ayahuasca preparation. For this purpose, a phytochemical characterization was performed, determining the content of flavonoids, total phenolic compounds, and analyzing the phenolic profile. Besides, 48 secondary metabolites were investigated by ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-Q/TOF-MS) and their concentration estimated with real standards when present. The antioxidant activity was evaluated by both the β-carotene bleaching test and DPPH free radical scavenging assay, and the anti-inflammatory activity was determined by a protein denaturation method. Finally, the antimicrobial properties were evaluated using the disc diffusion assay, resazurin microtiter method, anti-quorum sensing and anti-biofilm activity assays. The obtained results showed that, in general, the samples have a high content of phenolic compounds and flavonoids with noticeable differences, reflecting on remarkable antioxidant and anti-inflammatory activities. Significant antimicrobial properties were also observed, with emphasis on the effect of B. caapi and P. harmala on planktonic and biofilm cells of A. baumannii, inhibiting both the biofilm formation and the production of violacein pigment.

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“…Further, it can be noted the involvement of polyphenols namely hyperoside, (−)-epicatechin, caffeic acid and 2,5 dihydroxybenzoic acid in these activities. Caffeic acid, an important members of hydroxycinnamic acid, (−)-epicatechin and 2,5 dihydroxybenzoic acid are reported to be a good antioxidant with an excellent tyrosinase inhibition properties [ 77 , 78 , 79 , 80 ]. In fact, the assays performed on the B16 melanoma cell line showed that caffeic acid can inhibit melanin production by suppressing casein kinase 2 induced phosphorylation of tyrosinase in dose dependent [ 81 ].…”

Section: Resultsmentioning

confidence: 99%

Polyphenol Profile and Biological Activity Comparisons of Different Parts of Astragalus macrocephalus subsp. finitimus from Turkey

Sarıkürkçü

Zengin

2020

Biology

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The members of the genus Astragalus have great interest as traditional drugs in several folk systems including Turkey. In this sense, the present paper was aimed to explore the biological properties and chemical profiles of different parts (aerial parts, leaves, flowers, stems, and roots) of A. macrocephalus subsp. finitimus. Antioxidant (radical quenching, reducing power, and metal chelating) and enzyme inhibitory (α-amylase and tyrosinase) effects were investigated for biological properties. Regarding chemical profiles, individual phenolic compounds were detected by LC-MS, as well as total amounts. The leaves extract exhibited the strongest antioxidant abilities when compared with other parts. However, flowers extract had the best metal chelating ability. Hyperoside, apigenin, p-coumaric, and ferulic acids were identified as main compounds in the tested parts. Regarding enzyme inhibitory properties, tyrosinase inhibitory effects varied from IC50: 1.02 to 1.41 mg/mL. In addition, the best amylase inhibition effect was observed by leaves (3.36 mg/mL), followed by aerial parts, roots, stems, and flowers. As a result, from multivariate analysis, the tested parts were classified in three cluster. Summing up the results, it can be concluded that A. macrocephalus subsp. finitimus could be a precious source of natural bioactive agents in pharmaceutical, nutraceutical, and cosmeceutical applications.

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A review on gentisic acid as a plant derived phenolic acid and metabolite of aspirin: Comprehensive pharmacology, toxicology, and some pharmaceutical aspects

Cited by 101 publications

References 74 publications

Naringin protects endothelial cells from apoptosis and inflammation by regulating the Hippo-YAP Pathway

Naringin protects endothelial cells from apoptosis and inflammation by regulating the Hippo-YAP Pathway

Ayahuasca Beverages: Phytochemical Analysis and Biological Properties

Polyphenol Profile and Biological Activity Comparisons of Different Parts of Astragalus macrocephalus subsp. finitimus from Turkey

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