A review on fucoidan antitumor strategies: From a biological active agent to a structural component of fucoidan-based systems

Oliveira, Catarina; Neves, Nuno M.; Reis, Rui L.; Martins, Albino; Silva, Tiago H.

doi:10.1016/j.carbpol.2020.116131

Cited by 85 publications

(41 citation statements)

References 74 publications

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“…22−24 However, due its natural origin and intrinsic variability, not all fucoidan extracts may present this antitumor behavior. 7,27,34 Herein, as a first screening, fucoidan cytotoxicity and antitumor capability was tested in its soluble form. After this validation and trying to diminish the potential side effects of systemic therapies, an alternative and innovative therapeutic strategy is proposed by incorporating fucoidan on an electrospun nanofibrous mesh, aiming to act as a skin patch able to be easily and locally applied at the tumor site.…”

Section: Discussionmentioning

confidence: 99%

Fucoidan Immobilized at the Surface of a Fibrous Mesh Presents Toxic Effects over Melanoma Cells, But Not over Noncancer Skin Cells

et al. 2020

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The use of fucoidan, a marine-origin bioactive polymer, is herein proposed as a component of an innovative and effective strategy against melanoma, one of the most aggressive skin cancers. First, fucoidan antitumor activity, in its soluble form, was assessed presenting increased cytotoxicity over melanoma cells when compared to human dermal fibroblasts and keratinocytes. After this antitumor activity validation and trying to develop a more targeted and local strategy aiming to diminish the cytotoxic effects over noncancer cells, fucoidan was immobilized at the surface of an electrospun nanofiber mesh (NFM_Fu), envisioning the development of a therapeutic patch. The maximum immobilization concentration was 1.2 mg mL −1 , determined by the Toluidine Blue Assay and confirmed by XPS. Furthermore, NFM_Fu is more hydrophilic than NFM, presenting a contact angle of 36°, lower than the 121°of the control condition. NFM_Fu was able to reduce human melanoma cell viability by 50% without affecting human dermal fibroblasts and keratinocytes. Taken together, these results set the basis for a valuable approach for melanoma treatment.

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Section: Discussionmentioning

confidence: 99%

Fucoidan Immobilized at the Surface of a Fibrous Mesh Presents Toxic Effects over Melanoma Cells, But Not over Noncancer Skin Cells

et al. 2020

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“…The use of vitamin D in the Mpro receptor inhibitor reduces the expression of the dipeptidyl peptidase-4 receptor (DPP-4), a molecular virulent that reacts with the SARS-Cov-2 spike glycoprotein 28 . However, there is no rm evidence of the relationship between vitamin D and the death of patients 12,13 . Vitamin A has BE -7.99 kcal/mol and may also increase the immune system in the human body.…”

Section: Discussionmentioning

confidence: 99%

“…The molecular docking calculation was conducted using 27 compounds which are Nel na r, Lopinavir, Vitamin D [11][12][13] , Ritonavir, Dexamethasone, Baloxivir Marboxil, Alpha Tocopherol Acetate (Vitamine E), Vitamin A, Umifenovir, Darunavir, Cobicistat 6 , Meropenem 10 , Midazolam, Levo oxacin, Chloroquine Phosphate, Chloroquine 14 , Oseltamivir, Chloroquine Sulfate, Hydroxychloroquine, Cefotaxime, Salbutamol Sulfate, Remdesivir, Acetaminophen, Ribavirin, Favipiravir, Ascorbic acid (Vitamin C), and Acetylcysteine that were retrieved from pubchem.ncbi.nlm.nih.gov, and the receptor is obtained from www.rcsb.org with PDB ID: 6W63. Before molecular docking calculation was performed, the receptor and ligand were prepared using Chimera 1.14 15 .…”

Section: Methods Molecular Docking Calculationmentioning

confidence: 99%

Molecular Docking Studies of SARS-Cov-2 Mainprotease Potential Inhibitors

Utami¹,

Fitriani

Aziz

et al. 2020

Preprint

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BACKGROUND : SARS-Cov-2 causes an coronavirus disease 2019 (COVID-19), and the vaccines or drugs of this disease have not been found to inhibit this replication of the virus. Researchers are engaged in all fields of study to discover new potential inhibitors. This study aimed to compute the binding energy (BE) and interactions between the new potential inhibitors and the SARS-Cov-2 Mainprotease (Mpro).METHODS: In this study, we docked between twenty-seven patented drugs and the Mpro receptor (PDB ID: 6W63). The molecular docking calculation was performed using AutoDock Tools 1.5.6. software. Moreover, the information about the biological activity of ligands was calculated using the PASS online server. The result of the calculation was then analyzed and visualized using Biovia Discovery Studio Visualizer. Further calculation, such as the ligand-protein interaction using STITCH database and Lipinski’s rule five were employed in this research.RESULTS: The molecular docking calculation results showed that nelfinavir was strongly bound to Mpro with BE of -9,51 kcal/mol, followed by lopinavir, vitamin D, ritonavir, and dexamethasone. From these ligands, we considered dexamethasone because this ligand works as an anti-inflammatory agent. CONCLUSIONS: Following the calculation, nelfinavir, lopinavir, and dexamethasone are proposed as a potential inhibitor of the Mpro receptor, but there is a need for further investigation.

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“…Some specific components of the formulations, such as stearic acid [60,148] and stearyl alcohol [149] are necessary as a processing aid for HME. In addition, low Tg polymers such as HPC [60][61][62]150], Gelucire ® [119] and poly(vinylpyrrolidone-random-vinyl acetate) (PVP/VA) [150] are commonly used.…”

Section: Multi-unit Grdds Developed By Hot Melt Extrusion (Hme) and 3mentioning

confidence: 99%

“…For example, the preparation of HPC-based tablets combining HME and 3D printing techniques have been reported for the controlled release of domperidone [62] and theophylline [60], showing buoyancy over 10 h. Dumpa et al have fabricated, by means of HME/3D printing technologies, filaments of HPC/EC, which were used for the manufacture of core-shell gastroretentive floating tablets with pulsatile delivery of theophylline (the lag time for the pulsatile release of the drug was from 30 min to 6 h) [61]. The same group has recently reported the preparation of floating tablets for the administration of cinnarizine using HPC and Kollidon ® PVP/VA64 (random copolymer of vinylpyrrolidone and vinyl acetate, ratio 60:40) as matrix forming polymers [150].…”

Section: Multi-unit Grdds Developed By Hot Melt Extrusion (Hme) and 3mentioning

confidence: 99%

In-Depth Study into Polymeric Materials in Low-Density Gastroretentive Formulations

et al. 2020

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The extensive use of oral dosage forms for the treatment of diseases may be linked to deficient pharmacokinetic properties. In some cases the drug is barely soluble; in others, the rapid transit of the formulation through the gastrointestinal tract (GIT) makes it difficult to achieve therapeutic levels in the organism; moreover, some drugs must act locally due to a gastric pathology, but the time they remain in the stomach is short. The use of formulations capable of improving all these parameters, as well as increasing the resident time in the stomach, has been the target of numerous research works, with low-density systems being the most promising and widely explored, however, there is further scope to improve these systems. There are a vast variety of polymeric materials used in low-density gastroretentive systems and a number of methods to improve the bioavailability of the drugs. This works aims to expedite the development of breakthrough approaches by providing an in-depth understanding of the polymeric materials currently used, both natural and synthetic, their properties, advantages, and drawbacks.

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A review on fucoidan antitumor strategies: From a biological active agent to a structural component of fucoidan-based systems

Cited by 85 publications

References 74 publications

Fucoidan Immobilized at the Surface of a Fibrous Mesh Presents Toxic Effects over Melanoma Cells, But Not over Noncancer Skin Cells

Fucoidan Immobilized at the Surface of a Fibrous Mesh Presents Toxic Effects over Melanoma Cells, But Not over Noncancer Skin Cells

Molecular Docking Studies of SARS-Cov-2 Mainprotease Potential Inhibitors

In-Depth Study into Polymeric Materials in Low-Density Gastroretentive Formulations

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