The study focuses on the relationship between process skills and critical thinking in junior high school students in learning science. Besides, an interrelation between process skill and critical thinking skills was also investigated. The study used a mixed-method. A sample of this study is 689 students of total sampling technique. Quantitative data were analyzed by SPSS 21 to find descriptive statistics in terms of mean, min, max while qualitative were analyzed in-depth interviews. The finding shows that the science process skill of students in learning science whether urban and rural areas are good categories. The independent sample t-test shows that students’ science process skills in learning science in urban tend to be higher than in rural schools (p<0.01). Students’ critical thinking in learning science for urban areas is high but for rural areas is a fair category, with significance p<0.001. The regression showed the level of contribution of students’ science process skill influence as much as 51.5% for critical thinking. The other research result was found that students’ science process skill affects critical thinking in learning science. Moreover, a comparison between students’ science process skills and critical thinking based on their school location showed that urban is higher than rural.

Background Coronavirus disease 2019 (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2. COVID-19 has devastating effects on people in all countries and getting worse. We aim to investigate an in-silico docking analysis of phytochemical compounds from medicinal plants that used to combat inhibition of the COVID-19 pathway. There are several phytochemicals in medicinal plants, however, the mechanism of bioactive compounds remains unclear. These results are obtained from in silico research provide further information to support the inhibition of several phytochemicals. Methods Molecular docking used to determine the best potential COVID-19 M pro inhibitor from several bioactive compounds in Moringa oleifera, Allium cepa, Cocos nucifera, Psidium guajava, and Eucalyptus globulus. Molecular docking was conducted and scored by comparison with standard drugs remdesivir. ADME properties of selected ligands were evaluated using the Lipinski Rule. The interaction mechanism of the most recommended compound predicted using the STITCH database. Results There was no recommended compound in Moringa oleifera as a potential inhibitor for COVID-19. Oleanolic acid in Allium cepa, α-tocotrienol in Cocos nucifera, asiatic acid in Psidium guajava and culinoside in Eucalyptus globulus were the most recommended compound in each medicinal plant. Oleanolic acid was reported to exhibit anti-COVID-19 activity with binding energy was − 9.20 kcal/mol. This score was better than remdesivir as standard drug. Oleanolic acid interacted through the hydrogen bond with HIS41, THR25, CYS44, GLU166. Oleanolic acid binding with CASP-3, CASP-9, and XIAP signaling pathway. Conclusions Oleanolic acid in Allium cepa found as a potential inhibitor of COVID-19 M-pro that should be examined in future studies. These results suggest that oleanolic acid may be useful in COVID-19 treatment.

This study aims to determine the effect of human resource quality, professionalism of work, commitment to employeeperformance PDAM Jember partially and simultaneously. Research approach used in this study is quantitative. Population inthe company amounted to 150 and taken 75 respondents to use the sample with the sampling method is simple randomsampling or simple random sample by means of a lottery / raffle of names of employees PDAM Jember is then taken assamples used lottery of 75 names of employees Selected in the draw. Methods of analysis using multiple linear regressionanalysis were used to determine the influence of strong between the dependent variable and independent variables. The testresults and analysis conducted states that the variable quality of human resources and a significant positive effect on employeeperformance PDAM Jember Regency. Variable professionalism and significant positive effect on employee performancePDAM Jember. And variable commitment and significant positive effect on employee performance PDAM Jember. And thequality of human resources, professionalism, and commitment to simultaneously positive and significant influence on employeeperformance PDAM Jember Regency.

This tree generally is used as traditional medicine for several ailments. In this research, the In Silico approach using molecular docking has been applied to 11 compounds from the Ficus religiosa to the cyclooxygenase-2 (COX-2) receptor. This study aimed to predict the ability of 11 compounds from the Ficus religiosa in inhibition COX-2 enzyme as a prostaglandin source. The detailed information was obtained using the molecular docking approach. Docking simulation for 11 compounds was executed through AutodockVina embedded in MGL Tools 1.5.6. The lowest binding energy of the complexes was visualized by using Discovery Studio (Biova) software. It was found that campesterol provided the lowest binding energy to COX-2, while kaempferol strongly was tied to TYR385 and SER530 of the receptor. The compounds containing anti-inflammatory effect have the lowest binding energy, and binds to the residue as native ligands. This result is indicated that the compounds from Ficus religiosa have potency as an anti-inflammatory agent. Still, advanced research is needed to examine more ligands from Ficus religiosa to isolate the best conformation.

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