A Review on Fast Dissolving Tablets

Abstract

Fast dissolving tablet (FDT) is one such type of an innovative and unique drug delivery system which is swiftly gaining much attention in the research field of rapid dissolving technology. Few solid dosage forms like capsules and tablets are present days facing the problems like difficulty in swallowing (dysphagia), resulting in many incidences of non-compliance and making the therapy ineffective. FDT have benefits such as accurate dosing, easy portability and manufacturing, good physical and chemical stability and an ideal alternative for paediatric and geriatric patients. Fast dissolving Tablets are disintegrating and/or dissolve rapidly in the saliva without the need for water. Some tablets are designed to dissolve in saliva remarkably fast, within a few seconds, and are true fast-dissolving tablets. FTD contain agents to enhance the rate of tablet disintegration in the oral cavity, and are more appropriately termed fastdisintegrating tablets, as they may take up to a minute to completely disintegrate. FDTs formulations contain super disintegrants to enhance the disintegration rate of a tablet in the buccal cavity. This review describes the various advantages, limitations, desired characteristics, formulation aspects, super-disintegrate employed, technologies developed for FDTs, novel hole technology, evaluation tests, drugs used in fast dissolving tablets, marketed formulations and patented drugs.

Green synthesis, characterization, and antibacterial activity of Citrus lanatus based silver nanoparticles

“…In these investigations, pure Ag+ ion reduction was often observed 3-5 hours after a tiny aliquot of the sample was diluted in distilled water. [19][20][21][22] Another study on the green synthesis of silver Ag nanoparticles came to the conclusion that these particles might be used as antibacterial agents. The characterization research demonstrated that the particles created in nano dimensions would be just as useful in therapeutic formulations as antibiotics and other medications.…”

Formulation and Evaluation of Sublingual Tablets of Meclizine Hydrochloride

“…Then the sample was filtered and further dilution of this solution was prepared by taking 1ml solution in 10ml volumetric flask & diluted using phosphate buffer pH 6.8 and drug content were calculated by UV visible spectrophotometer at 228.80nm. [25] In vitro Disintegration Study: 4 tablets were taken from each formulation and dissolve in 4 different test tubes in 600 ml of phosphate buffer 6.8 pH in disintegration apparatus and the whole assembly was placed in phosphate buffer pH 6.8 at 37±0.5•c with beats added into the test tubes. The apparatus was started moving up and down in buffer to disintegrate tablets then time was noted of tablet disintegration in solution.…”