A review on fabricating tissue scaffolds using vat photopolymerization

Chartrain, Nicholas; Williams, Christopher B.; Whittington, Abby R.

doi:10.1016/j.actbio.2018.05.010

Cited by 192 publications

(158 citation statements)

References 225 publications

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“…LAP has proven to be an appropriate photoinitiator for the PEGDA monomers that are processed in the hybrid AM process. Firstly, because LAP is one of the most successfully used photoinitiators for biocompatible stereolithography [9,29]. Secondly, LAP has a relatively high water solubility and allows for polymerization with visible light (near-UV blue light) which finally leads to a reduced impact on the API compared to photoiniators such as Irgacure ® 2959 (BASF SE, Ludwigshafen, Germany) which need UV light for polymerization [33,34].…”

Section: Discussionmentioning

confidence: 99%

“…In the medical field, AM techniques are powerful tools for custom-made solutions for surgical instruments, prosthetics, and implants that meet the individual anatomical needs of the patient [3][4][5][6][7]. Furthermore, the technology holds promising potential for tissue engineering and bioprinting as well as organ and disease modeling [8][9][10][11][12]. However, in the pharmaceutical field the technology is still at an early stage [1,5].…”

Section: Introductionmentioning

confidence: 99%

“…Basically, multi-material SLA is reported in literature as well, primarily based on techniques using multiple material vats [18][19][20][21]. However, frequent vat switching or high numbers of different materials are especially technically challenging for such systems [9].…”

Section: Introductionmentioning

confidence: 99%

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A Novel Hybrid Additive Manufacturing Process for Drug Delivery Systems with Locally Incorporated Drug Depots

et al. 2019

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Here, we present a new hybrid additive manufacturing (AM) process to create drug delivery systems (DDSs) with selectively incorporated drug depots. The matrix of a DDS was generated by stereolithography (SLA), whereas the drug depots were loaded using inkjet printing. The novel AM process combining SLA with inkjet printing was successfully implemented in an existing SLA test setup. In the first studies, poly(ethylene glycol) diacrylate-based specimens with integrated depots were generated. As test liquids, blue and pink ink solutions were used. Furthermore, bovine serum albumin labeled with Coomassie blue dye as a model drug was successfully placed in a depot inside a DDS. The new hybrid AM process makes it possible to place several drugs independently of each other within the matrix. This allows adjustment of the release profiles of the drugs depending on the size as well as the position of the depots in the DDS.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Novel Hybrid Additive Manufacturing Process for Drug Delivery Systems with Locally Incorporated Drug Depots

et al. 2019

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“…The downside of light-assisted manufacturing is that the type of useable photo-polymers are limited and the use of solvents and photoinitiators may leave behind cytotoxic residues which may cause biochemical damage to cellular networks. Recent research has focused on discovering less cytotoxic photoinitiators in combination with more biocompatible, compliant, gel-like materials [33,64]. Printing using visible light mediated by chromophores avoids the use of harmful UV light that can damage encapsulated cells.…”

Section: Biocompatibility Biodegradability and Bioactivitymentioning

confidence: 99%

Engineered 3D Polymer and Hydrogel Microenvironments for Cell Culture Applications

2019

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The realization of biomimetic microenvironments for cell biology applications such as organ-on-chip, in vitro drug screening, and tissue engineering is one of the most fascinating research areas in the field of bioengineering. The continuous evolution of additive manufacturing techniques provides the tools to engineer these architectures at different scales. Moreover, it is now possible to tailor their biomechanical and topological properties while taking inspiration from the characteristics of the extracellular matrix, the three-dimensional scaffold in which cells proliferate, migrate, and differentiate. In such context, there is therefore a continuous quest for synthetic and nature-derived composite materials that must hold biocompatible, biodegradable, bioactive features and also be compatible with the envisioned fabrication strategy. The structure of the current review is intended to provide to both micro-engineers and cell biologists a comparative overview of the characteristics, advantages, and drawbacks of the major 3D printing techniques, the most promising biomaterials candidates, and the trade-offs that must be considered in order to replicate the properties of natural microenvironments.

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“…Therefore, GelMA has been extensively used in the last few years. 6,11,13,[15][16][17][18][19][20] Methacrylation allows fast covalent crosslinking in the presence of a photoinitiator and light exposure. 16,21 Methacrylation does not affect the RGD domains and allows the synthesis of materials with tunable mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

Glycerylphytate as an ionic crosslinker for 3D printing of multi-layered scaffolds with improved shape fidelity and biological features

et al. 2020

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A review on fabricating tissue scaffolds using vat photopolymerization

Cited by 192 publications

References 225 publications

A Novel Hybrid Additive Manufacturing Process for Drug Delivery Systems with Locally Incorporated Drug Depots

A Novel Hybrid Additive Manufacturing Process for Drug Delivery Systems with Locally Incorporated Drug Depots

Engineered 3D Polymer and Hydrogel Microenvironments for Cell Culture Applications

Glycerylphytate as an ionic crosslinker for 3D printing of multi-layered scaffolds with improved shape fidelity and biological features

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