A review on ethnobotany, phytochemistry and pharmacology on Terminalia belerica (Bibhitaki)

Sharma, Panshul; Verma, Kapil Kumar; Raj, Hans; Thakur, Nagesh

doi:10.22270/jddt.v11i1-s.4739

Cited by 9 publications

(6 citation statements)

References 23 publications

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“…In a study using the agar well diffusion method, antimicrobial activity was evaluated against Gram-positive or negative bacteria such as Staphylococcus aureus, Staphylococcus epidermidis, Bacillus cereus, Pseudomonas aeruginosa, Salmonella spp, Escherichia coli and Azotobacter spp etc. Ethanolic extracts showed good activity against the tested bacterial isolates compared to methanol, chloroform or aqueous extract 78 .…”

Section: Anti-microbial Activitymentioning

confidence: 93%

Anti-Inflammatory and Anti-Microbial Action of Triphala Guggulu: A Review

Rawat¹,

Yadav²,

Mitra³

et al. 2022

Int. J. Res. Ayurveda Pharm.

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Triphala Guggulu, an Ayurvedic herbal formulation, consists of dried powder of fruits of three plants commonly known as Triphala: Emblica officinalis Gaertn. (Euphorbiaceae), Terminalia bellerica Roxb. (Combretaceae) and Terminalia chebula Retz. (Combretaceae) along with Piper longum Linn. (Piperaceae), combined with the oleo-gum resin of Commiphora wightii Arnott. Bhandari (Burseraceae). It is mentioned in the Ayurvedic Formulary of India (AFI) taken from Sharngadhar Samhita for several therapeutic uses. This formulation is indicated in the treatment of Bhagandara (fissure-in-ano), Gulma (Benign growths), Shotha (Inflammation) and Arsha (Piles) by Acharya Sharangdhara Mishra in his book. This review article aims to evaluate all the experimental work done on the anti-inflammatory and anti-microbial action of constituents of Triphala Guggulu. A review of all research work was done from the Central Council of Research in Ayurvedic Sciences (CCRAS) database of medicinal plants and online research journals. The outcome of this study shows that all Triphala Guggulu ingredients can work as anti-inflammatory and antibacterial activity against a wide range of microbes. Thus, Triphala Guggulu is an effective formulation to cure infectious wounds and normalize gut motility, beneficial in health conditions such as Piles, Fistula, Inflammation etc.

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Section: Anti-microbial Activitymentioning

confidence: 93%

Anti-Inflammatory and Anti-Microbial Action of Triphala Guggulu: A Review

Rawat¹,

Yadav²,

Mitra³

et al. 2022

Int. J. Res. Ayurveda Pharm.

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“…T. bellirica is also widely used in Unani, Siddha, and Chinese systems of traditional medicine [3][4][5]. They have a range of pharmacological activities such as laxative, antioxidant, antidiabetic, analgesic, antiulcer, antifungal, antibacterial, anti-helminthic, anti-pyritic properties and anti-hypertensive activity through in-vitro and in-vivo studies [4][5][6][7][8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

“…bellirica is also widely used in Unani, Siddha, and Chinese systems of traditional medicine [3][4][5]. They have a range of pharmacological activities such as laxative, antioxidant, antidiabetic, analgesic, antiulcer, antifungal, antibacterial, anti-helminthic, anti-pyritic properties and anti-hypertensive activity through in-vitro and in-vivo studies [4][5][6][7][8][9][10][11][12][13][14][15]. The dried ripe fruit of T. bellirica is used against various health problems like hepatitis, bronchitis, asthma, dyspepsia, piles, cough, diarrhea, dropsy, leprosy, eye disease, scorpion-sting and as a hair tonic [4,5,[15][16].…”

Section: Introductionmentioning

confidence: 99%

“…They have a range of pharmacological activities such as laxative, antioxidant, antidiabetic, analgesic, antiulcer, antifungal, antibacterial, anti-helminthic, anti-pyritic properties and anti-hypertensive activity through in-vitro and in-vivo studies [4][5][6][7][8][9][10][11][12][13][14][15]. The dried ripe fruit of T. bellirica is used against various health problems like hepatitis, bronchitis, asthma, dyspepsia, piles, cough, diarrhea, dropsy, leprosy, eye disease, scorpion-sting and as a hair tonic [4,5,[15][16]. The fruits of T. bellirica have several ethnomedicinal uses by people and have multiple medicinal properties identified by various reserachers from time to time [6,9,[17][18][19][20][21][22][23][24][25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

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Phytochemical Profiling of Aqueous Methanol Extract of Terminalia bellirica from Bokaro District of Jharkhand, India

Mahato,

Prasad,

Mahato

2024

EJMP

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Plants are a vital source of medicine for human being from ancient times. Various plant parts are highly medicinal due to the presence of different bioactive compounds and secondary metabolites. Many of these compounds present in medicinal plants are unknown to the scientific community. T. bellirica is distributed in tropical parts of the world and is a known ethnomedicinal plant that is the reservoir of various bioactive compounds. The present investigated the bioactive and secondary metabolite present in the fruits of T. bellirica collected from the Bokaro district and has been analysed using Gas chromatography-Mass spectrometry analysis. The investigation found 55 compounds from the methanol extract of the fruit sample of T. bellirica. Among the recorded compounds, Pyrogallol is the major constituent with 85% area in the chromatogram, followed by 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one (DDMP)with 5% area, and the rest of the compounds are altogether 10% of the total. In conclusion, the present study recorded and highlighted a total of 55 bioactive compounds from the dry fruits and pericarp, which is more than a double of the compounds earlier known from the plant species. Further, among the recorded biochemical compounds, the concentration of Pyrogallol was alone more than 85% of the total compounds found from the methanol extract of the fruit sample of T. bellirica.

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“…Phy-Blica-D has been reported to contain phytochemical compounds, including 6-galloylglucose, 1-O-galloylglycerol, fertaric acid, vanilpyruvic acid, (2S)-5,7,3′,4′-tetrahydroxyflavanone 6-C-glucoside, naringerin, agecorynin B, castavinol, chalconaringenin 2′-rhamnosyl-(1→4)-xyloside, beta-rhodomycin, sericoside, alliosterol 1-(4″-galactosylrhamnoside) 16-galactoside, licorice saponin A3, asparasaponin II, licorice saponin G2, betavulgaroside II, glycyrrhizic acid, and 6-gingerol [ 17 ]. Moreover, a literature review demonstrated that the phytochemical compounds of Phy-Blica-D herbal component are various, but the main chemicals are phenolic, flavonoid, alkaloids, glycosides, tannin, and triterpenoid, as shown in Table 1 [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

Gastroprotective and Antioxidative Effects of the Traditional Thai Polyherbal Formula Phy-Blica-D against Ethanol-Induced Gastric Ulcers in Rats

et al. 2021

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Phy-Blica-D is a traditional Thai polyherbal formula that has reduced oxidative stress in non-communicable diseases. However, evidence supporting the gastroprotective effects of Phy-Blica-D has not been previously reported. Therefore, this study aimed to evaluate the gastroprotective effects of Phy-Blica-D against gastric ulcers in rats and investigate the potential underlying mechanism. To estimate the possible mechanisms of action, we examined the levels of oxidative stress markers, such as reactive oxygen species (ROS) and malondialdehyde (MDA), as well as antioxidant enzymes, including catalase (CAT), superoxide dismutase (SOD), and glutathione (GSH). According to our results, rats treated with only 80% ethanol (vehicle group) exhibited significant increases in their ulcer area and ulcer index (UI). Moreover, the levels of ROS and MDA markedly increased in the vehicle group compared with the normal control group. Daily oral administration of Phy-Blica-D (500 and 1000 mg/kg) for 7 days not only significantly decreased the ulcer area and UI, but also remarkably decreased the ROS and MDA levels in gastric tissue. Gastric ulcers induced by ethanol had significantly decreased antioxidant enzyme activities (CAT and SOD) and non-enzymatic antioxidant (GSH), whereas pretreatment with Phy-Blica-D significantly improved the activities of CAT, SOD, and GSH. Moreover, after exposure to ethanol, the rats exhibited a significantly increased level of inducible nitric oxide synthase (iNOS), which was reduced after treatment with Phy-Blica-D. These findings suggest that Phy-Blica-D potentially exerts its gastroprotective effects by suppressing oxidative stress and stimulating antioxidant enzymes, which is one of the causes of destruction of cell membranes, and it is involved in the pathogenesis of acute gastric ulcers induced by ethanol.

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A review on ethnobotany, phytochemistry and pharmacology on Terminalia belerica (Bibhitaki)

Cited by 9 publications

References 23 publications

Anti-Inflammatory and Anti-Microbial Action of Triphala Guggulu: A Review

Anti-Inflammatory and Anti-Microbial Action of Triphala Guggulu: A Review

Phytochemical Profiling of Aqueous Methanol Extract of Terminalia bellirica from Bokaro District of Jharkhand, India

Gastroprotective and Antioxidative Effects of the Traditional Thai Polyherbal Formula Phy-Blica-D against Ethanol-Induced Gastric Ulcers in Rats

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