A review on electrospun magnetic nanomaterials: methods, properties and applications

Jia, Yifan; Yang, Congyi; Chen, Xueyang; Xue, Wenqing; Hutchins-Crawford, Helena J.; Yu, Qianqian; Topham, Paul D.; Wang, Linge

doi:10.1039/d1tc01477c

Cited by 39 publications

(17 citation statements)

References 487 publications

(429 reference statements)

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“…Among the broad range of nanoparticular materials, magnetic nanoparticles can be applied to diverse purposes, either practically for electromagnetic shielding, hyperthermia therapy or as catalysts [ 25 , 26 , 27 ], or as a model system for basic research on magnetic properties of nanofibers and nanofiber composites [ 28 , 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

Electrospinning Nanofiber Mats with Magnetite Nanoparticles Using Various Needle-Based Techniques

et al. 2022

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Electrospinning can be used to produce nanofiber mats containing diverse nanoparticles for various purposes. Magnetic nanoparticles, such as magnetite (Fe3O4), can be introduced to produce magnetic nanofiber mats, e.g., for hyperthermia applications, but also for basic research of diluted magnetic systems. As the number of nanoparticles increases, however, the morphology and the mechanical properties of the nanofiber mats decrease, so that freestanding composite nanofiber mats with a high content of nanoparticles are hard to produce. Here we report on poly (acrylonitrile) (PAN) composite nanofiber mats, electrospun by a needle-based system, containing 50 wt% magnetite nanoparticles overall or in the shell of core–shell fibers, collected on a flat or a rotating collector. While the first nanofiber mats show an irregular morphology, the latter are quite regular and contain straight fibers without many beads or agglomerations. Scanning electron microscopy (SEM) and atomic force microscopy (AFM) reveal agglomerations around the pure composite nanofibers and even, round core–shell fibers, the latter showing slightly increased fiber diameters. Energy dispersive X-ray spectroscopy (EDS) shows a regular distribution of the embedded magnetic nanoparticles. Dynamic mechanical analysis (DMA) reveals that mechanical properties are reduced as compared to nanofiber mats with smaller amounts of magnetic nanoparticles, but mats with 50 wt% magnetite are still freestanding.

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Section: Introductionmentioning

confidence: 99%

Electrospinning Nanofiber Mats with Magnetite Nanoparticles Using Various Needle-Based Techniques

et al. 2022

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“…Electrospinning, as a versatile technology to produce micro- and nanometer fibers, − is widely used in various fields, especially in tissue engineering and drug delivery. − Electrospun fibrous scaffolds have been explored to deliver photothermal-chemotherapeutic agents in a localized manner for synergistic cancer therapy. − Examples include multiwalled carbon nanotubes/doxorubicin MWCNTs/DOX-co-loaded poly- l -lactic acid (PLLA) fibers, DOX-loaded polypyrrole hollow fibers, gold nanocage/DOX-incorporated polycaprolactone (PCL) fibers, polydopamine (PDA)-coated PCL-DOX fibers, and PDA/curcumin-capped PLLA/poly(citrate siloxane) (PLLA/PCS) fibers . This type of implantable scaffold based on fibers of polymers/inorganic particles/drugs increases drug accumulation that is concentrated at the lesion site, thus avoiding excessive drug circulation.…”

Section: Introductionmentioning

confidence: 99%

Can Photothermal Post-Operative Cancer Treatment Be Induced by a Thermal Trigger?

Chen

Cheng

et al. 2021

ACS Appl. Mater. Interfaces

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One of the current challenges in the post-operative treatment of breast cancer is to develop a local therapeutic vector for preventing recurrence and metastasis. Herein, we develop a core−shell fibrous scaffold comprising phase-change materials and photothermal/chemotherapy agents, as a thermal trigger for programmable-response drug release and synergistic treatment. The scaffold is obtained by in situ growth of a zeolitic imidazolate framework-8 (ZIF-8) shell on the surface of poly(butylene succinate)/lauric acid (PBS/LA) phase-change fibers (PCFs) to create PCF@ZIF-8. After optimizing the core−shell and phase transition behavior, gold nanorods (GNRs) and doxorubicin hydrochloride (DOX) co-loaded PCF@ZIF-8 scaffolds were shown to significantly enhance in vitro and in vivo anticancer efficacy. In a healthy tissue microenvironment at pH 7.4, the ZIF-8 shell ensures the sustained release of DOX. If the tumor recurs, the acidic microenvironment induces the decomposition of the ZIF-8 shell. Under the second near-infrared (NIR-II) laser treatment, GNR-induced thermal not only directly destroys the relapsed tumor cells but also accelerates DOX release by inducing the phase transition of LA. Our study sheds light on a well-designed programmable-response trigger, which provides a promising strategy for post-operative recurrence prevention of cancer.

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“…Application of fibrous nanomaterials in areas of social and economic importance, such as regenerative medicine and biotechnology, has experienced significant progress in recent years [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Light-to-Heat Converting ECM-Mimetic Nanofiber Scaffolds for Neuronal Differentiation and Neurite Outgrowth Guidance

2022

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The topological cues of fibrous scaffolds (in particular extracellular matrix (ECM)-mimetic nanofibers) have already proven to be a powerful tool for influencing neuronal morphology and behavior. Remote photothermal optical treatment provides additional opportunities for neuronal activity regulation. A combination of these approaches can provide “smart” 3D scaffolds for efficient axon guidance and neurite growth. In this study we propose two alternative approaches for obtaining biocompatible photothermal scaffolds: surface coating of nylon nanofibers with light-to-heat converting nanoparticles and nanoparticle incorporation inside the fibers. We have determined photoconversion efficiency of fibrous nanomaterials under near infrared (NIR) irradiation, as well as biocompatible photothermal treatment parameters. We also measured photo-induced intracellular heating upon contact of cells with a plasmonic surface. In the absence of NIR stimulation, our fibrous scaffolds with a fiber diameter of 100 nm induced an increase in the proportion of β3-tubulin positive cells, while thermal stimulation of neuroblastoma cells on nanoparticles-decorated scaffolds enhanced neurite outgrowth and promoted neuronal maturation. We demonstrate that contact guidance decorated fibers can stimulate directional growth of processes of differentiated neural cells. We studied the impact of nanoparticles on the surface of ECM-mimetic scaffolds on neurite elongation and axonal branching of rat hippocampal neurons, both as topographic cues and as local heat sources. We show that decorating the surface of nanofibers with nanoparticles does not affect the orientation of neurites, but leads to strong branching, an increase in the number of neurites per cell, and neurite elongation, which is independent of NIR stimulation. The effect of photothermal stimulation is most pronounced when cultivating neurons on nanofibers with incorporated nanoparticles, as compared to nanoparticle-coated fibers. The resulting light-to-heat converting 3D materials can be used as tools for controlled photothermal neuromodulation and as “smart” materials for reconstructive neurosurgery.

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A review on electrospun magnetic nanomaterials: methods, properties and applications

Abstract: Magnetic materials display attractive properties for a wide range of applications. More recently, interest has turned to significantly enhancing their behaviour for advanced technologies, by exploiting the remarkable advantages that...

Cited by 39 publications

References 487 publications

Electrospinning Nanofiber Mats with Magnetite Nanoparticles Using Various Needle-Based Techniques

Electrospinning Nanofiber Mats with Magnetite Nanoparticles Using Various Needle-Based Techniques

Can Photothermal Post-Operative Cancer Treatment Be Induced by a Thermal Trigger?

Light-to-Heat Converting ECM-Mimetic Nanofiber Scaffolds for Neuronal Differentiation and Neurite Outgrowth Guidance

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