A Review on Electrochemical Sensors and Biosensors Used in Phenylalanine Electroanalysis

Dinu, Ancuța; Apetrei, Constantin

doi:10.3390/s20092496

Cited by 27 publications

(18 citation statements)

References 69 publications

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“…These diseases are caused by high levels of amino acid (AAs) concentrations: phenylalanine (Phe), tyrosine (Tyr), methionine (Met), arginine (Arg), Leucine (Leu), Isoleucine (Ile) and Valine (Val). The clinical symptoms of metabolic diseases may be detected right from birth, in certain cases, but also during a lifetime, by using various methods of identification [5]. Most manifestations due to the lack or impairment of these AAs lead to dementia, mental problems such as intellectual disability in newborns, mood disorder, Parkinson's disease, rickets, liver damage, hepatocellular carcinoma and even death without treatment in the first days of life [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…The clinical symptoms of metabolic diseases may be detected right from birth, in certain cases, but also during a lifetime, by using various methods of identification [5]. Most manifestations due to the lack or impairment of these AAs lead to dementia, mental problems such as intellectual disability in newborns, mood disorder, Parkinson's disease, rickets, liver damage, hepatocellular carcinoma and even death without treatment in the first days of life [4,5]. Moreover, the lack of these AAs may lead to depression, hypochondria or albinism [5,6].…”

Section: Introductionmentioning

confidence: 99%

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Voltammetric Determination of Phenylalanine Using Chemically Modified Screen-Printed Based Sensors

Dinu

Apetrei

2020

Chemosensors

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This paper describes the sensitive properties of screen-printed carbon electrodes (SPCE) modified by using three different electroactive chemical compounds: Meldola’s Blue, Cobalt Phthalocyanine and Prussian Blue, respectively. It was demonstrated that the Prussian Blue (PB) modified SPCE presented electrochemical signals with the highest performances in terms of electrochemical process kinetics and sensitivity in all the solutions analyzed. PB-SPCE was demonstrated to detect Phe through the influence it exerts on the redox processes of PB. The PB-SPCE calibration have shown a linearity range of 0.33–14.5 µM, a detection limit (LOD) of 1.23 × 10−8 M and the standard deviation relative to 3%. The PB-SPCE sensor was used to determine Phe by means of calibration and standard addition techniques on pure samples, on simple pharmaceutical samples or on multicomponent pharmaceutical samples. Direct determination of the concentration of 4 × 10−6–5 × 10−5 M Phe in KCl solution showed that the analytical recovery falls in the range of 99.75–100.28%, and relative standard deviations in the range of 2.28–3.02%. The sensors were successfully applied to determine the Phe in pharmaceuticals. The validation of the method was performed by using the FTIR, and by comparing the results obtained by PB-SPCE in the analysis of three pharmaceutical products of different concentrations with those indicated by the producer.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Voltammetric Determination of Phenylalanine Using Chemically Modified Screen-Printed Based Sensors

Dinu

Apetrei

2020

Chemosensors

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“…Another important neurotransmitter, serotonin, is synthesized from tryptophan [31]. Phenylalanine in turn, converted into tyrosine, produces the precursor of catecholamines [32]. Histidine is a precursor of histamine, a biogenic amine which plays numerous physiological roles [33].…”

Section: Discussionmentioning

confidence: 99%

The influence of lithium and/or selenium on plasma amino acids profile in rats

Kiełczykowska¹,

Musik²,

Luchowska-Kocot³

et al. 2021

Ann Agric Environ Med.

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Introduction. Selenium belongs to essential microelements and is used in agriculture. Lithium is used in medicine and the possibility of its exposure by environmental pollution has been reported. Both elements have been found to be connected with amino acids metabolism. Objective. The aim of the study was to compare the effect of lithium and selenium on plasma amino acids in rats, and to evaluate the influence of selenium in organisms exposed to lithium. Materials and method. The effect of selenium (0.5 mg/kg b.w., orally as Na 2 SeO 3 ) and/or lithium (2.7 mg/kg b.w., orally as Li 2 CO 3 ) given for 6 weeks on the plasma profile of selected amino acids in rats was studied. The concentrations of amino acids were determined using ion exchange chromatography with the aid of an amino acids analyzer AAA400. Results. A significant effect of lithium on plasma amino acids profile was found in rats, much greater than for selenium. Selenium treatment slightly increased Tau, Phe, Tyr, Ala, Trp, Ser and Gln, while Lys and Orn were enhanced in a significant way. In contrast, Li-treatment caused a well-marked increase in Phe, Orn, Ala, His, Trp, Asp and Gln, whereas all the others were only slightly increased. Co-treatment resulted in a significant increase in Orn and Trp, a slight enhancement of Phe, Lys and His, while the rest remained unchanged. Conclusions. A significant effect of lithium alone on plasma amino acids profile in animals was demonstrated, with a much less influence of selenium alone. Co-treatment generally resulted in a slight or no effect. The slight selenium influence seems important regarding its agricultural application and the growing interest in its supplementation. Results concerning lithium could contribute to the research regarding the mechanism of Li action.

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“…Consequently, they also play the role of recognition elements for target cells, and the substrate selectivity leads to the detection of specific classes of phenolic compounds or other chemical compounds. Their use on the electrode’s surface is not a novelty, but necessitates solving certain typical issues which result from the obligation of correctly immobilizing the enzyme, from the compatibility with more types of materials and from the modifications of the conductive properties of the active surface [ 73 ].…”

Section: Analytical Methods Used In Determining Cgamentioning

confidence: 99%

A Review on Electrochemical Sensors and Biosensors Used in Chlorogenic Acid Electroanalysis

Munteanu

Apetrei

2021

IJMS

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Chlorogenic acid (5-O-caffeoylquinic acid) is a phenolic compound from the hydroxycinnamic acid family. Epidemiological, biological, and biochemical studies concur to support the beneficial role of chlorogenic acid in human health, along with other dietary phenolic compounds. Thus, chlorogenic acid has been reported to exert inhibitory effects on carcinogenesis in the large intestine, liver, and tongue, and a protective action on oxidative stress in vivo, together with anti-inflammatory, antidiabetic and antihypertensive activities. It is also claimed to have antifungal, antibacterial and antiviral effects with relatively low toxicity and side effects, alongside properties that do not lead to antimicrobial resistance. Due to its importance, numerous methods for determining chlorogenic acid (CGA), as well as for its derivatives from coffee beans and other plants, were elaborated. The most frequently used methods are infrared spectroscopy, high performance liquid chromatography (HPLC), capillary electrophoresis, liquid chromatography-mass spectrometry and chemiluminescence. Although these methods proved to be efficient for quantifying CGA and its derived products, a number of deficiencies were identified: they are time consuming, laborious, and require expensive instruments. Therefore, electrochemical methods have been developed and used in the determination of CGA in different nutraceuticals or food products. The present review aims to present the main progresses and performance characteristics of electrochemical sensors and biosensors used to detect CGA, as it is reported in a high number of relevant scientific papers published mainly in the last decade.

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A Review on Electrochemical Sensors and Biosensors Used in Phenylalanine Electroanalysis

Cited by 27 publications

References 69 publications

Voltammetric Determination of Phenylalanine Using Chemically Modified Screen-Printed Based Sensors

Voltammetric Determination of Phenylalanine Using Chemically Modified Screen-Printed Based Sensors

The influence of lithium and/or selenium on plasma amino acids profile in rats

A Review on Electrochemical Sensors and Biosensors Used in Chlorogenic Acid Electroanalysis

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