A Review on Electrochemical Sensors and Biosensors Used in Chlorogenic Acid Electroanalysis

Abstract

Chlorogenic acid (5-O-caffeoylquinic acid) is a phenolic compound from the hydroxycinnamic acid family. Epidemiological, biological, and biochemical studies concur to support the beneficial role of chlorogenic acid in human health, along with other dietary phenolic compounds. Thus, chlorogenic acid has been reported to exert inhibitory effects on carcinogenesis in the large intestine, liver, and tongue, and a protective action on oxidative stress in vivo, together with anti-inflammatory, antidiabetic and antihypertensive activities. It is also claimed to have antifungal, antibacterial and antiviral effects with relatively low toxicity and side effects, alongside properties that do not lead to antimicrobial resistance. Due to its importance, numerous methods for determining chlorogenic acid (CGA), as well as for its derivatives from coffee beans and other plants, were elaborated. The most frequently used methods are infrared spectroscopy, high performance liquid chromatography (HPLC), capillary electrophoresis, liquid chromatography-mass spectrometry and chemiluminescence. Although these methods proved to be efficient for quantifying CGA and its derived products, a number of deficiencies were identified: they are time consuming, laborious, and require expensive instruments. Therefore, electrochemical methods have been developed and used in the determination of CGA in different nutraceuticals or food products. The present review aims to present the main progresses and performance characteristics of electrochemical sensors and biosensors used to detect CGA, as it is reported in a high number of relevant scientific papers published mainly in the last decade.

Development of a Chemically Modified Sensor Based on a Pentapeptide and Its Application for Sensitive Detection of Verbascoside in Extra Virgin Olive Oil

“…The construction of a robust sensor by modifying its surface with pentapeptide solution and fixing it by cross-linking involves obtaining analytically important parameters, including sensitivity, lifetime, detection, and quantification limits [ 45 ].…”

On-Site Multisample Determination of Chlorogenic Acid in Green Coffee by Chemiluminiscent Imaging

“…Regarding the in situ-based analytical systems, sensors and biosensors have also been studied in depth. A review focused on this topic has been recently published by Munteanu and Apetrei [ 6 ]. Recent advances in sensitive materials for electrochemical sensors and biosensors have led to methodologies, with low µM detection limits, which is an advantage if the content of this type of antioxidant is at a trace level [ 22 ].…”

“…In particular, CHLA is linked to green coffee and green coffee extract-based products’ health benefits. That fact, together with the relevance of the global coffee market, has led to a growing interest in the development of analytical methods for the quantification of this antioxidant [ 6 ].…”

Electrochemical strategies for detection of Diazinon: A review

“…In most biosensors developed so far, electrochemical detection has been used in one way or another, i.e., amperometric, voltammetric, and impedimetric detection. The basic principle for electrochemical biosensors is that chemical reactions between the immobilized biomolecule and target analyte produce or consume electrons which cause some change in the measurable electrical properties of the solution, such as electric current, conductance, and potential [125][126][127][128].…”