A review on chitosan nanoparticles applications in drug delivery

Roy, Sheetal G; Shirsat, Namrata S; Mishra, Ashish C; Waghulde, Sandeep O; Kale, Mohan K.

doi:10.22271/phyto.2018.v7.isp6.1.01

Cited by 13 publications

(11 citation statements)

References 4 publications

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“…Rats of group 2 showed significant increases in values of glucose, insulin, total protein, globulin, triglycerides, cholesterol, LDL-C, and VLDL-C, whereas the levels of albumin and HDL-C were significantly declined. These findings are in agreement with other experimental diabetic investigations [8, 35–37].…”

Section: Discussionsupporting

confidence: 94%

Comparative Study on the Influence of Some Medicinal Plants on Diabetes Induced by Streptozotocin in Male Rats

Almalki

Alghamdi

Al-Attar

2019

BioMed Research International

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Medicinal plants have played an important role in the treatment of many diseases. Medicinal plants are believed to be well appropriate with the human body and to produce less side influences than the pharmaceuticals. Kingdom of Saudi Arabia has abundant and wide variety of medicinal plants whose therapeutic effects have not been adequately studied. The aim of this study was to investigate the hypoglycemic activities of the extracts of three plant species collected from Albaha region of Saudi Arabia including Olea oleaster (Oleaceae family) leaves (OLE), Juniperus procera (Cupressaceae family) leaves (JLE), and Opuntia ficus-indica (Cactaceae family) stems (OSE) on streptozotocin (STZ) diabetic male rats. The animals were distributed into eight groups. The first group was used as normal control. The second group was diabetic control. Diabetic rats of the third, fourth, and fifth groups were supplemented with OLE, JLE, and OSE, respectively. Normal rats of the sixth, seventh, and eighth groups were treated with OLE, JLE, and OSE, respectively. As expected, the mean of body weight was significantly decreased in rats of the second group. Significant increase in the value of serum glucose and decline of insulin value were observed in rats of the second group. Several alterations of lipid and protein profile and oxidative stress markers were noted in diabetic control rats. Severe histopathological alterations of pancreatic tissues were observed in untreated diabetic rats. The obtained results showed that OLE, JLE, and OSE attenuated the physiological and histopathological alterations. These new data indicate that the attenuation influences of OLE, JLE, and OSE attributed to their antioxidant properties confirmed by oxidative stress markers evaluation.

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Section: Discussionsupporting

confidence: 94%

Comparative Study on the Influence of Some Medicinal Plants on Diabetes Induced by Streptozotocin in Male Rats

Almalki

Alghamdi

Al-Attar

2019

BioMed Research International

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“…This group helps with providing the cationic nature, thus providing chitosan with various properties that include antimicrobial, wound healing, and mucoadhesive properties. The pKa value makes chitosan insoluble in water but soluble in various types of acidic solutions [ 104 , 105 ]. The mechanism of functionalization results in the development of N-modified, O-modified, and N,O-modified chitosan, thereby providing chitosan with a wide range of biological activities.…”

Section: Chitosan Nanoparticlesmentioning

confidence: 99%

Functionalized Chitosan Nanomaterials: A Jammer for Quorum Sensing

et al. 2021

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The biggest challenge in the present-day healthcare scenario is the rapid emergence and spread of antimicrobial resistance due to the rampant use of antibiotics in daily therapeutics. Such drug resistance is associated with the enhancement of microbial virulence and the acquisition of the ability to evade the host’s immune response under the shelter of a biofilm. Quorum sensing (QS) is the mechanism by which the microbial colonies in a biofilm modulate and intercept communication without direct interaction. Hence, the eradication of biofilms through hindering this communication will lead to the successful management of drug resistance and may be a novel target for antimicrobial chemotherapy. Chitosan shows microbicidal activities by acting electrostatically with its positively charged amino groups, which interact with anionic moieties on microbial species, causing enhanced membrane permeability and eventual cell death. Therefore, nanoparticles (NPs) prepared with chitosan possess a positive surface charge and mucoadhesive properties that can adhere to microbial mucus membranes and release their drug load in a constant release manner. As the success in therapeutics depends on the targeted delivery of drugs, chitosan nanomaterial, which displays low toxicity, can be safely used for eradicating a biofilm through attenuating the quorum sensing (QS). Since the anti-biofilm potential of chitosan and its nano-derivatives are reported for various microorganisms, these can be used as attractive tools for combating chronic infections and for the preparation of functionalized nanomaterials for different medical devices, such as orthodontic appliances. This mini-review focuses on the mechanism of the downregulation of quorum sensing using functionalized chitosan nanomaterials and the future prospects of its applications.

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“…Polymer degradation occurs in the surrounding media or presence of enzymes (by chemical reaction). Biodegradable polymers open due to cleavage of covalent bonds between them and bio erodible polymers degrade due to dissolution of linking chains without any change in chemical structure of the molecule [ 3 , 60 ].…”

Section: Drug Release From Chitosan Nps In Biological Fluidsmentioning

confidence: 99%

“…It is protonated and polycationic in nature and forms complexes with diverse anions like lipids, proteins, DNA, alginate, pectin and poly(acrylic acid). The physicomechanical properties (solubility, toxicity, hydrophobicity) of chitosan depend on the degree of deacetylation and molecular weight of chitosan depending on the source of chitin [ 2 , 3 ]. The attractiveness of chitosan lies in it being biodegradable, biocompatible, simple, stable, nontoxic and an intensively researched polymer looking at the magnitude of papers available on chitosan functionalization and applications across diverse sectors.…”

Section: Introductionmentioning

confidence: 99%

Chitosan Nanoparticles-Insight into Properties, Functionalization and Applications in Drug Delivery and Theranostics

et al. 2021

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Nanotechnology-based development of drug delivery systems is an attractive area of research in formulation driven R&D laboratories that makes administration of new and complex drugs feasible. It plays a significant role in the design of novel dosage forms by attributing target specific drug delivery, controlled drug release, improved, patient friendly drug regimen and lower side effects. Polysaccharides, especially chitosan, occupy an important place and are widely used in nano drug delivery systems owing to their biocompatibility and biodegradability. This review focuses on chitosan nanoparticles and envisages to provide an insight into the chemistry, properties, drug release mechanisms, preparation techniques and the vast evolving landscape of diverse applications across disease categories leading to development of better therapeutics and superior clinical outcomes. It summarizes recent advancement in the development and utility of functionalized chitosan in anticancer therapeutics, cancer immunotherapy, theranostics and multistage delivery systems.

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A review on chitosan nanoparticles applications in drug delivery

Abstract: Innovation development and standardization of Novel Herbal Formulation

Cited by 13 publications

References 4 publications

Comparative Study on the Influence of Some Medicinal Plants on Diabetes Induced by Streptozotocin in Male Rats

Comparative Study on the Influence of Some Medicinal Plants on Diabetes Induced by Streptozotocin in Male Rats

Functionalized Chitosan Nanomaterials: A Jammer for Quorum Sensing

Chitosan Nanoparticles-Insight into Properties, Functionalization and Applications in Drug Delivery and Theranostics

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