A review on chemistry and biological significance of benzimidaole nucleus

Abstract

Benzimidazole is a heterocyclic aromatic organic compound. It is an important pharmacophore and privileged structure in medicinal chemistry. It plays a very important role with plenty of useful therapeutic activities such as : antiulcers, antihypertensives, analgesic, anti-inflammatory, anti-virals, antifungals, anticancers, and antihistaminics. The review of the literature shows that the benzimidazole derivatives are outstandingly effective compound and number of reviews available for biochemical and pharmacological studies conformed that their molecules are useful against a wide variety of micro-organisms. Because of their importance, the methods for their synthesis have become a focus of Synthetic Organic Chemists. Therefore in the present review we tried to compile the chemistry of different derivative of substituted benzimidazole as well as various pharmacological activities and some of the important methodologies used for the synthesis.

Crystal structure and Hirshfeld surface analysis of 4-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]phthalonitrile dimethyl sulfoxide monosolvate

“…Benzimidazole and its derivatives are some of the oldest and chemically most-studied nitrogen-containing aromatic heterocyclic compounds (Srestha et al, 2014). They have a wide range of applications in medicinal chemistry and in biological processes including as anticancer, antiulcer, antifungal and anti-inflammatory agents, and exhibit antimycobacterial and antioxidant activities (El Rashedy & Aboul-Enein, 2013;Gaba et al, 2014;Kathiravan et al, 2012).…”

N‐Acylbenzotriazole as Efficient Ligand in Copper‐Catalyzed O‐Arylation Leading to Diverse Benzoxazoles

“…The extraordinary properties of benzotriazole moiety have also been harnessed in development of some very promising and efficient ligands particularly for coupling reactions . Recently, 2‐substituted azoles emerged as one of the most fascinating entity which can be understood in terms of remarkable range of biological, pharmaceutical, industrial and analytical significance of benzoxazoles, benzimidazoles, and benzothiazoles . The importance of benzoxazoles can be further visualized in terms of its presence as structural core in diverse range of natural and synthetic molecules, for example, antimycobacterial agents, pseudopteroxazole ( I ), UK‐1 ( II ) AJI9561 ( III ), HIV reverse transcriptase inhibitor L‐697,661 ( IV ), estrogen receptor‐ β agonist ERB‐041 ( V ), selective peroxisome proliferator‐activated receptor γ antagonist JTP‐426467 ( VI ) and anticancer agent NSC‐693638 ( VII ) (Figure ).…”

Synthesis, Characterization and Biological screening of novel benzimidazole derivatives for certain pharmacological activities

“…The review of the literature showed benzimidazole derivatives to be useful pharmacological compounds in terms of various biochemical and pharmacological studies. [4]…”