Synthesis, Characterization and Biological screening of novel benzimidazole derivatives for certain pharmacological activities

Abstract

Benzimidazole derivatives are prepared by microwave synthesis method using 1, 2phenylenediamine and various carboxylic acid and their derivatives (aldehydes).All synthesized compounds were characterized by physicochemical properties, IR, NMR etc. The compounds are screened for different biological activities like antimicrobial, anti-diabetic, anti-inflammatory, anti-depressant and analgesic activities. Compounds U1 showed significant activity, compounds U1 and U5 showed significant anti-diabetic activity, compounds U2 and U3 showed significant anti-inflammatory activity, compounds U2, U3, U4 and U5 showed significant antidepressant activity and compounds U4 and U5 showed significant analgesic activity.

Synthesis and PTP1B/TCPTP Inhibitory Activity Evaluation of Novel 2,5-Disubstituted-1,3,4-thiadiazolamide Derivatives Containing Carbazole/Benzimidazole Moity

“…咔唑(Cz)和苯并咪唑(BZM)是两种重要的含氮杂环 化合物. 咔唑衍生物具有如抗糖尿病 [16] 、抗肿瘤 [16] 、抗 菌 [17] 等重要的生物活性, 苯并咪唑衍生物具有如抗糖 尿病 [18,19] 、抗癌 [20] 、抗高血压 [20] 、抗病毒 [20] 等广谱的药 理性质. 咔唑和苯并咪唑已成为未来药物设计有吸引力 的模板.…”