A review on brain age prediction models

Soumya Kumari, L.K.; Sundarrajan, R.

doi:10.1016/j.brainres.2023.148668

Cited by 6 publications

(1 citation statement)

References 49 publications

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“…For chronic stress, our results are consistent with evidence indicating a positive link between chronic stress (AL index) and WM volume(12, 13, 51), WM tracks(15, 52), and WM microstructure(14), while we further provide evidence that the association between AL index and WM BAG may be causal. In contrast to earlier studies that used multiple singular measurements, WM BAG offers a holistic estimation of brain aging that is derived from 39 brain-wide white matter fractional anisotropy tracks using a machine learning model, providing a single measure of brain aging that is predictive of cognitive decline(23) and standardized for use across diverse studies(53).…”

Section: Discussionmentioning

confidence: 99%

Association between allostatic load and accelerated white matter brain aging: findings from the UK Biobank

Feng,

Ye,

et al. 2024

Preprint

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White matter (WM) brain age, a neuroimaging-derived biomarker indicating WM microstructural changes, helps predict dementia and neurodegenerative disorder risks. The cumulative effect of chronic stress on WM brain aging remains unknown. In this study, we assessed cumulative stress using a multi-system composite allostatic load (AL) index based on inflammatory, anthropometric, respiratory, lipidemia, and glucose metabolism measures, and investigated its causal association with WM brain age gap (BAG), computed from diffusion tensor imaging data using a machine learning model, among 22 951 European ancestries aged 40 to 69 (51.40% women) from UK Biobank. Linear regression, Mendelian randomization, along with inverse probability weighting and doubly robust methods, were used to evaluate the impact of AL on WM BAG adjusting for age, sex, socioeconomic, and lifestyle behaviors. We found increasing one AL score unit significantly increased WM BAG by 0.29 years in association analysis and by 0.33 years in Mendelian randomization causal analysis. The age- and sex-stratified analysis showed consistent results among participants 45-54 and 55-64 years old, with no significant sex difference. This study demonstrated that higher chronic stress caused accelerated brain aging, highlighting the importance of stress management in reducing dementia and neurodegenerative disease risks.

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Section: Discussionmentioning

confidence: 99%

Association between allostatic load and accelerated white matter brain aging: findings from the UK Biobank

Feng,

Ye,

et al. 2024

Preprint

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Embracing complexity of (brain) aging

Polidori

2024

FEBS Letters

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Aging is a multifactorial process occurring in a pathophysiological continuum which leads to organ and system functional loss. While aging is not a disease, its pathophysiological continuum predisposes to illness and multimorbidity clusters which share common biomolecular mechanisms—the pillars of aging. Brain aging and neurodegeneration share many hallmarks with other age‐related diseases. The central nervous system is often the weakest link susceptible to the aging process and its deterioration, resulting in cognitive impairment and other symptoms; the aging process is associated with proteostasis collapse, stem cell exhaustion, repair mechanisms, altered brain nutrient sensing, endothelial changes, inflammation, oxidative distress, and energy unbalance, as well as other disturbances. These mechanisms are highly interwoven, and considerable research is aimed at their disentanglement and detection of their clinically relevant impact, particularly in order to identify pharmacological and non‐pharmacological preventive and therapeutic strategies.

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Cognitive and Emotional Effect of a Multi-species Probiotic Containing Lactobacillus rhamnosus and Bifidobacterium lactis in Healthy Older Adults: A Double‐Blind Randomized Placebo‐Controlled Crossover Trial

Ruiz-Gonzalez,

Cardona,

Rueda-Ruzafa

et al. 2024

Probiotics & Antimicro. Prot.

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As the population ages, cognitive decline becomes more common. Strategies targeting the gut-brain axis using probiotics are emerging to achieve improvements in neuropsychiatric and neurological disorders. However, the beneficial role of probiotics on brain function in healthy older adults remains unclear. Our aim was to evaluate a multi-species probiotic formulation as a therapeutic approach to reduce emotional and cognitive decline associated with aging in healthy adults. A randomized double-blind placebo-controlled crossover trial was conducted. The study involved a 10-week intervention where participants consumed the assigned probiotic product daily, followed by a 4-week washout period before the second condition started. Cognitive function was assessed using the Mini-Mental State Examination (MMSE) and the Psychological Experiments Construction Language Test Battery. At the emotional level, the Beck Depression Inventory (BDI) and the State-Trait Anxiety Inventory (STAI) were used. Thirty-three participants, recruited between July 2020 and April 2022, ingested a multispecies probiotic (Lactobacillus rhamnosus and Bifidobacterium lactis). After the intervention, noticeable enhancements were observed in cognitive function (mean difference 1.90, 95% CI 1.09 to 2.70, p < 0.005), memory (mean difference 4.60, 95% CI 2.91 to 6.29, p < 0.005) by MMSE and digit task, and depressive symptoms (mean difference 4.09, 95% CI 1.70 to 6.48, p < 0.005) by BDI. Furthermore, there were significant improvements observed in planning and problem-solving skills, selective attention, cognitive flexibility, impulsivity, and inhibitory ability. Probiotics administration improved cognitive and emotional function in older adults. Limited research supports this, requiring more scientific evidence for probiotics as an effective therapy for cognitive decline. This study has been prospectively registered at ClinicalTrials.gov (NCT04828421; 2020/July/17).

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A review on brain age prediction models

Cited by 6 publications

References 49 publications

Association between allostatic load and accelerated white matter brain aging: findings from the UK Biobank

Association between allostatic load and accelerated white matter brain aging: findings from the UK Biobank

Embracing complexity of (brain) aging

Cognitive and Emotional Effect of a Multi-species Probiotic Containing Lactobacillus rhamnosus and Bifidobacterium lactis in Healthy Older Adults: A Double‐Blind Randomized Placebo‐Controlled Crossover Trial

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