Association between allostatic load and accelerated white matter brain aging: findings from the UK Biobank
Li Feng,
Zhenyao Ye,
Zewen Du
et al.
Abstract:White matter (WM) brain age, a neuroimaging-derived biomarker indicating WM microstructural changes, helps predict dementia and neurodegenerative disorder risks. The cumulative effect of chronic stress on WM brain aging remains unknown. In this study, we assessed cumulative stress using a multi-system composite allostatic load (AL) index based on inflammatory, anthropometric, respiratory, lipidemia, and glucose metabolism measures, and investigated its causal association with WM brain age gap (BAG), computed f… Show more
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