A Review on Biodentine, a Contemporary Dentine Replacement and Repair Material

Malkondu, Özlem; Kazandağ, Meriç Karapınar; Kazazoğlu, Ender

doi:10.1155/2014/160951

Cited by 245 publications

(262 citation statements)

References 45 publications

(88 reference statements)

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“…(9). This has many similarities to the composition of Biodentine, which is primarily calcium silicates with a radiopacifier (10).…”

Section: Methodsmentioning

confidence: 77%

Dental Material Choices for Pulp Therapy in Paediatric Dentistry

Ha¹,

Kahler²,

Walsh³

2017

Eur Endod J

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Objective: The purpose of this study was to assess the restorative choices for pulpal therapy by members of the Australian and New Zealand Society of Paediatric Dentistry (ANZSPD). Methods: Members of the ANZSPD were sent an online survey asking about the procedures that they performed and their choice of dental materials. Results: The respondents were 31 general dentists (GD) and 55 specialist paediatric dentists (PD). Materials used for indirect pulp capping included calcium hydroxide [Ca(OH) 2 ] cement (CHC), glass ionomer cement or resin-modified glass ionomer cement (GIC/RMGIC), Ca(OH) 2 paste (CHP) and mineral trioxide aggregate (MTA). Materials for direct pulp capping included MTA, CHP and CHC. Materials and techniques used for pulpotomy included MTA, ferric sulphate, formocresol and diathermy, CHP and CHC. GD and PD were similar in their choice of materials. However, there was no preferred product for pulp therapy. Most GD learnt how to use MTA from CPD lectures, while some PD learnt how to use MTA from their postgraduate training as well as CPD lectures. Many GD and PD did not have hands-on training from their education on how to use MTA (GD: 80%, PD: 43%). Most would like to attend hands-on MTA courses (GD: 86%, PD: 65%). Conclusion: There was no clear preferred product for the various types of pulp therapy in paediatric dentistry. Education appears to be the major barrier to the use of MTA rather than the cost of MTA.

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“…(9). This has many similarities to the composition of Biodentine, which is primarily calcium silicates with a radiopacifier (10).…”

Section: Methodsmentioning

confidence: 77%

Dental Material Choices for Pulp Therapy in Paediatric Dentistry

Ha¹,

Kahler²,

Walsh³

2017

Eur Endod J

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“…Among such materials, Biodentine™ (BD, Septodont, Saint Maur des Fossés, France), 1 was specifically designed as a "dentin replacement" material for applications such as root perforations, apexification, treatment of resorptive lesions, as well as a retrograde filling material in endodontic surgery. 2 Biodentine™ is composed of a mixed powder and liquid system: the powder contains tricalcium silicate (main component), calcium carbonate (as filling material), zirconium oxide (as radiopacifier), with traces of dicalcium silicate, calcium oxide, and iron oxide; the liquid phase of BD consists of a water-soluble polymer solution (water-reducing agent), using calcium chloride to decrease the setting time. 3 Biodentine was described as a bioactive dentin substitute with apatite formation after immersion in phosphate solution, 4 as the elemental uptake of Ca and Si into root canal dentin was found to be more prominent for Biodentine than for MTA.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, due to its biological properties as acid-resistant cement, it can be used as a root repair material. 2 Biodentine is reported as presenting better biological properties than other tricalcium silicate cements such as MTA. A previous study has shown that the dynamic interaction of Biodentine with the dentin and pulp tissue interface stimulates pulp cell recruitment and differentiation, upregulates transformation factors (gene expression), and promotes dentinogenesis.…”

Section: Introductionmentioning

confidence: 99%

BiodentineTM is cytocompatible with human primary osteoblasts

et al. 2017

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Calcium silicate-based materials have been widely studied due to their resemblance to, and similar applicability of, mineral trioxide aggregate (MTA). Among these, Biodentine™ (BD) was specifically designed as a "dentin replacement" material for applications such as root perforations, apexification, treatment of resorptive lesions, and as a retrograde filling material. The present study aimed to assess the in vitro response of human primary osteoblasts to BD using MTA Angelus TM as a reference material, by simultaneously analyzing three different cell viability parameters, namely mitochondrial activity, membrane integrity, and cell density. BD and MTA extracts were prepared by incubation on culture media for 24 h or 42 days after mixing. Primary human osteoblasts were exposed to extracts for 24 h, at 37 o C with 5% CO 2 , and cell viability was evaluated by the XTT, NRU, and CVDE assays. Both materials induced cell viability levels higher than 70% when extracted for 24 h. However, when cells were exposed to extracts with increased conditioning times, MTA presented significant cytotoxic effects (p < 0.05) in comparison to the control and MTA at 24 h. After 42 days, the XTT assay identified a significant reduction in cell viability by BD when compared to the control (p<0.05), despite the fact that levels above the 70% viability cutoff were attained for biocompatible materials. It can be concluded that BD is cytocompatible with human primary osteoblasts, indicating its adequacy in direct contact with bone tissues.

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“…294 Differences in the patterns of responses between GD and PD were assessed according to their frequency distribution using Fisher's exact test, with GraphPad™ statistical software (http://graphpad.com/quickcalcs/catMenu/). P values of less than 0.05 were regarded as significant.…”

Section: Methodsmentioning

confidence: 99%

“…153 PC is typically calcium silicates with a minority component of calcium aluminate while Biodentine TM (Septodont, Saint-Maur-des-Fossés, France) has calcium silicates without calcium aluminates. 294 Therefore, as the differences are tenuous, Biodentine has been grouped with MTA for the purpose of this study. 294 The questionnaire offered several multiple-choice answers with an option for the respondent to type their own answer (in "Other") should they differ to the options provided.…”

Section: Endodontics;mentioning

confidence: 99%

Mineral Trioxide Aggregate: A review of clinical usage and investigations of the effects of modifying particle size

Ha¹

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A Review on Biodentine, a Contemporary Dentine Replacement and Repair Material

Cited by 245 publications

References 45 publications

Dental Material Choices for Pulp Therapy in Paediatric Dentistry

Dental Material Choices for Pulp Therapy in Paediatric Dentistry

BiodentineTM is cytocompatible with human primary osteoblasts

Mineral Trioxide Aggregate: A review of clinical usage and investigations of the effects of modifying particle size

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