A Review on Bioactivities of Honey Bee Venom

Azam, Nur Kabidul; Ahmed, Md. Nasir; Biswas, Shwapon; Ara, Nargis; Rahman, Md. Masuder; Hirashima, Akinori; Hasan, Md. Nazmul

doi:10.9734/arrb/2018/45028

Cited by 18 publications

(25 citation statements)

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“…This venom or toxin can be called Apitoxin; since the word was originated from the Latin apis (bee) and toxikon (venom) [51]. In a recent review, Azam et al [52] compiled information on the history, chemical composition and scientific evidence concerning the Apitoxin pharmaceutic research and different medical uses. The honey bee venom had been studied for its action on mammals although little is known about its action on insects [53,54].…”

Section: Introductionmentioning

confidence: 99%

Quantitative and Qualitative Impacts of Selected Arthropod Venoms on the Larval Haemogram of the Greater Wax Moth, Galleria mellonella (Linnaeus) (Lepidoptera: Pyralidae)

Ghoneim

Hamadah

Tanani

et al. 2021

JALSI

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The greater wax moth, Galleria mellonella (Linnaeus) (Lepidoptera: Pyralidae) is the most destructive pest of honey bee, Apis mellifera Linnaeus (Hymenoptera: Apidae), throughout the world. The present study was conducted to determine the quantitative and qualitative impairing effects of the arthropod venoms, viz., death stalker scorpion Leiurus quinquestriatus (Hemprich & Ehrenberg) venom (SV), oriental Hornet (wasp) Vespa orientalis Linnaeus venom (WV) and Apitoxin of A. mellifera (AP) on the larval haemogram. For this purpose, the 3rd instar larvae were treated with LC50 of each of these venoms (3428.9, 2412.6, and 956.16 ppm, respectively). The haematological investigation was conducted in haemolymph of the 5th and 7th (last) instar larvae. The important results could be summarized as follows. Five basic types of the freely circulating haemocytes in the haemolymph of last instar (7th) larvae of G. mellonella had been identified: Prohemocytes (PRs), Plasmatocytes (PLs), Granulocytes (GRs), Spherulocytes (SPs) and Oenocytoids (OEs). All venoms unexceptionally prohibited the larvae to produce normal hemocyte population (count). No certain trend of disturbance in the differential hemocyte counts of circulating hemocytes in larvae of G. mellonella after treatment with the arthropod venoms. Increasing or decreasing population of the circulating hemocytes seemed to depend on the potency of the venom, hemocyte type and the larval instar. In PRs of last instar larvae, some cytopathological features had been observed after treatment with AP or WV, but SV failed to cause cytopathological features. With regard to PLs, some cytopathological features had been observed after treatment with AP while both SV and WV failed to cause cytopathological features in this hemocyte type. No venom exhibited cytopathological effects on GRs, SPs or OEs.

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Section: Introductionmentioning

confidence: 99%

Quantitative and Qualitative Impacts of Selected Arthropod Venoms on the Larval Haemogram of the Greater Wax Moth, Galleria mellonella (Linnaeus) (Lepidoptera: Pyralidae)

Ghoneim

Hamadah

Tanani

et al. 2021

JALSI

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“…By far the best studied insect venom is that of the honeybee (Apis mellifera) [46][47][48][49] and in a purified form is an FDA-approved product for several painful inflammatory conditions [198,199]. Several systematic reviews have confirmed that A. mellifera venom can help alleviate pain in these conditions, but it remains unclear exactly which venom components are responsible for this effect or what mechanisms [200,201].…”

Section: Discussionmentioning

confidence: 99%

“…To date, the majority of insect venom research has focused on eusocial hymenoptera. This literature is so extensive that only the aspects most directly relevant to the study of pompilid venoms will be mentioned [46][47][48][49]. While these venoms are extremely interesting and worthy of study, the multifunctional nature of parasitoid venoms alongside the sheer taxonomic diversity of parasitoid lineages suggests that they represent much richer prospects for discovering novel toxin activities or promising lead compounds for the design of new molecular tools or medications [50,51].…”

Section: Introductionmentioning

confidence: 99%

A Short Review of the Venoms and Toxins of Spider Wasps (Hymenoptera: Pompilidae)

Dashevsky

Rodríguez

2021

Toxins

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Parasitoid wasps represent the plurality of venomous animals, but have received extremely little research in proportion to this taxonomic diversity. The lion’s share of investigation into insect venoms has focused on eusocial hymenopterans, but even this small sampling shows great promise for the development of new active substances. The family Pompilidae is known as the spider wasps because of their reproductive habits which include hunting for spiders, delivering a paralyzing sting, and entombing them in burrows with one of the wasp’s eggs to serve as food for the developing larva. The largest members of this family, especially the tarantula hawks of the genus Pepsis, have attained notoriety for their large size, dramatic coloration, long-term paralysis of their prey, and incredibly painful defensive stings. In this paper we review the existing research regarding the composition and function of pompilid venoms, discuss parallels from other venom literatures, identify possible avenues for the adaptation of pompilid toxins towards human purposes, and future directions of inquiry for the field.

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“…The main active constituent is melittin, which has relatively low toxicity (Bogdanov, 2017). In a recent review, Azam et al (2018) compiled information on the history, chemical composition and scientific evidence concerning the honey bee Apitoxin pharmaceutic research and different medical uses. Very recently, examined the toxicity and disruptive effects of growth and development of G. mellonella.…”

Section: Introductionmentioning

confidence: 99%

Deteriorated Adult Performance and Reproduction of the Greater Wax Moth, (Galleria mellonella (Lepidoptera: Pyralidae) by the Honey Bee Apitoxin

Ghoneim

Tanani

Hamadah

et al. 2019

Egyptian Academic Journal of Biological Sciences. A, Entomology

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The greater wax moth, Galleria mellonella is an important pest of wax combs of the honey bee in the world. The current investigation aimed to assess the effects of Apitoxin on the most important adult life parameters and reproduction of this pest. The freshly ecdysed 3 rd instar larvae were treated with a series of Apitoxin concentrations (4000, 2000, 1000, 500, 250, 125 ppm) via the artificial diet. The present results can be summarized as follows. The adult emergence was slightly blocked only at the higher three concentration levels. Apitoxin failed to affect both adult survival and morphogenesis. The total longevity was significantly shortened, in a dosedependent course. The ovarian maturation (pre-oviposition) period was prolonged, except the highest one at which this period was slightly shortened, as an odd datum. The reproductive lifetime (oviposition period) was remarkably shortened, in no certain trend. Also, the post-oviposition period was considerably shortened. Apitoxin exerted a diverse action on the reproductive efficiency of adult females since the oviposition rate was enhanced or inhibited, depending on the concentration, but in no certain trend. Both fecundity and fertility had been significantly reduced, in a dose-dependent course. The incubation period was considerably prolonged in a dose-dependent manner.

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A Review on Bioactivities of Honey Bee Venom

Cited by 18 publications

References 0 publications

Quantitative and Qualitative Impacts of Selected Arthropod Venoms on the Larval Haemogram of the Greater Wax Moth, Galleria mellonella (Linnaeus) (Lepidoptera: Pyralidae)

Quantitative and Qualitative Impacts of Selected Arthropod Venoms on the Larval Haemogram of the Greater Wax Moth, Galleria mellonella (Linnaeus) (Lepidoptera: Pyralidae)

A Short Review of the Venoms and Toxins of Spider Wasps (Hymenoptera: Pompilidae)

Deteriorated Adult Performance and Reproduction of the Greater Wax Moth, (Galleria mellonella (Lepidoptera: Pyralidae) by the Honey Bee Apitoxin

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