A review on antimicrobial botanicals, phytochemicals and natural resistance modifying agents from Apocynaceae family: Possible therapeutic approaches against multidrug resistance in pathogenic microorganisms

Anand, Uttpal; Nandy, Samapika; Mundhra, Avinash; Das, Nirmalendu; Pandey, Devendra Kumar; Dey, Abhijit

doi:10.1016/j.drup.2020.100695

Cited by 89 publications

(60 citation statements)

References 195 publications

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“…These phytochemical substances are found in very diverse quantities and provide a wide range of pharmacological effects (Sati et al 2010). The pharmacological effect can be antimicrobial (Anand et al 2020;Jeevanandam et al 2017), antioxidant (Khan et al 2019;Suma andUrooj 2012), antiviral (Ben-Shabat et al 2020;Chojnacka et al 2020), anticancer (Shukla and Mehta 2015;Singh et al 2016), antidiabetic (Teoh and Das 2018;Vinayagam et al 2017), antihypertensive (Ronchi et al 2015), neuroprotective (Kumar and Khanum 2012), and so on. It is thought to be due to phytochemical bio components in these natural materials, including tannins, glucosides, saponins, steroids, flavonoids, and triterpenoids, polyphenols, phenols, and others.…”

Section: Discussionmentioning

confidence: 99%

Short Communication: Ethnobotanical and ecological studies of medicinal plants in a mangrove forest in Mempawah District, West Kalimantan, Indonesia

2021

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Abstract. Arbiastutie Y, Diba F, Masriani. 2021. Short Communication: Ethnobotanical and ecological studies of medicinal plants in a mangrove forest in Mempawah District, West Kalimantan, Indonesia. Biodiversitas 22: 3164-3170. The mangrove forest Polaria Tanjung Pagar in Mendalok Village, Mempawah District, West Kalimantan, Indonesia, is a mangrove forest maintained by the local community. Currently, this mangrove forest has become one of the tourist attractions, not only visited by local and national, but also foreign tourists. This study aims to identify plants in Polaria Tanjung Pagar mangrove forest Kalimantan with the potential for medicinal uses. The research used a survey method in the mangrove forest by conducting an inventory of the medicinal plants found in the mangrove forest. Observations were made using a transect line with the total area understudy of 0.012 ha and sampling intensity of 0.4%. The investigation was based on cross-checking the traditional use of medicinal plants by the surrounding communities and the scientific literature. The results showed 13 types of medicinal plants (including tree and understorey plants) from 6 different families, i.e., Acrostichum aureum, Aegiceras corniculatum, Avicennia marina, Avicennia alba, Bruguiera parviflora, Bruguiera gymnorrhiza, Bruguiera cylindrica, Ceriops decandra, Rhizophora apiculata, Rhizophora stylosa, Rhizophora mucronata, Xylocarpus moluccensis, and Sonneratia caseolaris. The community structure of the mangrove forest had moderate diversity for tree species and low diversity for understorey plant species, with an H' valued at 2.39 and 0.25, respectively.

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Section: Discussionmentioning

confidence: 99%

Short Communication: Ethnobotanical and ecological studies of medicinal plants in a mangrove forest in Mempawah District, West Kalimantan, Indonesia

2021

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“…However, several factors involving the conversion of a desirable compound into a valuable drug candidate include availability, bioavailability, intellectual property, and the strong pharmacokinetic profile of the compound ( 268 , 290 ). Sometimes researchers find great bioactivity of a plant-derived compound in in vitro analysis but unfortunately, the desired compound becomes ineffectual under in vivo conditions ( 291 ). In vivo is a very crucial step to move to animal trials or subsequent clinical trials.…”

Section: Drug Discovery From Psms: Addressing the Major Challenges Tomentioning

confidence: 99%

Plants Metabolites: Possibility of Natural Therapeutics Against the COVID-19 Pandemic

et al. 2020

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COVID-19, a disease induced by SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2), has been the cause of a worldwide pandemic. Though extensive research works have been reported in recent days on the development of effective therapeutics against this global health crisis, there is still no approved therapy against SARS-CoV-2. In the present study, plant-synthesized secondary metabolites (PSMs) have been prioritized to make a review focusing on the efficacy of plant-originated therapeutics for the treatment of COVID-19. Plant metabolites are a source of countless medicinal compounds, while the diversity of multidimensional chemical structures has made them superior to treat serious diseases. Some have already been reported as promising alternative medicines and lead compounds for drug repurposing and discovery. The versatility of secondary metabolites may provide novel antibiotics to tackle MDR (Multi-Drug Resistant) microbes too. This review attempted to find out plant metabolites that have the therapeutic potential to treat a wide range of viral pathogens. The study includes the search of remedies belonging to plant families, susceptible viral candidates, antiviral assays, and the mode of therapeutic action; this attempt resulted in the collection of an enormous number of natural therapeutics that might be suggested for the treatment of COVID-19. About 219 plants from 83 families were found to have antiviral activity. Among them, 149 plants from 71 families were screened for the identification of the major plant secondary metabolites (PSMs) that might be effective for this pandemic. Our investigation revealed that the proposed plant metabolites can serve as potential anti- SARS-CoV-2 lead molecules for further optimization and drug development processes to combat COVID-19 and future pandemics caused by viruses. This review will stimulate further analysis by the scientific community and boost antiviral plant-based research followed by novel drug designing.

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“…Other research on G. sylvestre extracts suggested that this extract could stimulate the release of insulin in vitro by permeabilizing the β-cell [ 115 ]. Several mechanisms have been proposed to explain the antidiabetic activity of G. sylvestre ( Figure 12 ) [ 113 , 116 , 117 ]. According to these literature, the action of Gymnemic acids in diabetic treatment was reported to be able to stimulate pancreatic cell production, thereby increasing insulin production, increase insulin sensitivity and insulin activity, help to control and stabilize blood glucose concentration in the body.…”

Section: Bioactive Compounds From Plants Having Type 2 Antidiabetimentioning

confidence: 99%

Bioactive Compounds in Anti-Diabetic Plants: From Herbal Medicine to Modern Drug Discovery

Tran

Bao

2020

Biology

201

102

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Natural products, including organisms (plants, animals, or microorganisms) have been shown to possess health benefits for animals and humans. According to the estimation of the World Health Organization, in developing countries, 80% of the population has still depended on traditional medicines or folk medicines which are mostly prepared from the plant for prevention or treatment diseases. Traditional medicine from plant extracts has proved to be more affordable, clinically effective and relatively less adverse effects than modern drugs. Literature shows that the attention on the application of phytochemical constituents of medicinal plants in the pharmaceutical industry has increased significantly. Plant-derived secondary metabolites are small molecules or macromolecules biosynthesized in plants including steroids, alkaloids, phenolic, lignans, carbohydrates and glycosides, etc. that possess a diversity of biological properties beneficial to humans, such as their antiallergic, anticancer, antimicrobial, anti-inflammatory, antidiabetic and antioxidant activities Diabetes mellitus is a chronic disease result of metabolic disorders in pancreas β-cells that have hyperglycemia. Hyperglycemia can be caused by a deficiency of insulin production by pancreatic (Type 1 diabetes mellitus) or insufficiency of insulin production in the face of insulin resistance (Type 2 diabetes mellitus). The current medications of diabetes mellitus focus on controlling and lowering blood glucose levels in the vessel to a normal level. However, most modern drugs have many side effects causing some serious medical problems during a period of treating. Therefore, traditional medicines have been used for a long time and play an important role as alternative medicines. Moreover, during the past few years, some of the new bioactive drugs isolated from plants showed antidiabetic activity with more efficacy than oral hypoglycemic agents used in clinical therapy. Traditional medicine performed a good clinical practice and is showing a bright future in the therapy of diabetes mellitus. World Health Organization has pointed out this prevention of diabetes and its complications is not only a major challenge for the future, but essential if health for all is to be attained. Therefore, this paper briefly reviews active compounds, and pharmacological effects of some popular plants which have been widely used in diabetic treatment. Morphological data from V-herb database of each species was also included for plant identification.

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A review on antimicrobial botanicals, phytochemicals and natural resistance modifying agents from Apocynaceae family: Possible therapeutic approaches against multidrug resistance in pathogenic microorganisms

Cited by 89 publications

References 195 publications

Short Communication: Ethnobotanical and ecological studies of medicinal plants in a mangrove forest in Mempawah District, West Kalimantan, Indonesia

Short Communication: Ethnobotanical and ecological studies of medicinal plants in a mangrove forest in Mempawah District, West Kalimantan, Indonesia

Plants Metabolites: Possibility of Natural Therapeutics Against the COVID-19 Pandemic

Bioactive Compounds in Anti-Diabetic Plants: From Herbal Medicine to Modern Drug Discovery

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