A review on advances in the applications of spider silk in biomedical issues

Bakhshandeh, Behnaz; Nateghi, Seyedeh Saba; Gazani, Mohammad Maddah; Dehghani, Zahra; Mohammadzadeh, Fatemeh

doi:10.1016/j.ijbiomac.2021.09.201

Cited by 34 publications

(26 citation statements)

References 138 publications

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“…Further improvement is in demand to achieve better osteogenic capacity (Wu et al, 2021). Due to outstanding tunability, SF can be modified into different formats for certain applications, such as films, hydrogels and porous structures (Bakhshandeh et al, 2021). Besides, different organic and inorganic components can be mixed with pure SF to fabricate hybrid scaffolds to improve mechanical and biological performance (Wu et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Silk fibroin scaffolds: A promising candidate for bone regeneration

Lin²,

Zhao³

et al. 2022

Front. Bioeng. Biotechnol.

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It remains a big challenge in clinical practice to repair large-sized bone defects and many factors limit the application of autografts and allografts, The application of exogenous scaffolds is an alternate strategy for bone regeneration, among which the silk fibroin (SF) scaffold is a promising candidate. Due to the advantages of excellent biocompatibility, satisfying mechanical property, controllable biodegradability and structural adjustability, SF scaffolds exhibit great potential in bone regeneration with the help of well-designed structures, bioactive components and functional surface modification. This review will summarize the cell and tissue interaction with SF scaffolds, techniques to fabricate SF-based scaffolds and modifications of SF scaffolds to enhance osteogenesis, which will provide a deep and comprehensive insight into SF scaffolds and inspire the design and fabrication of novel SF scaffolds for superior osteogenic performance. However, there still needs more comprehensive efforts to promote better clinical translation of SF scaffolds, including more experiments in big animal models and clinical trials. Furthermore, deeper investigations are also in demand to reveal the degradation and clearing mechanisms of SF scaffolds and evaluate the influence of degradation products.

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Section: Introductionmentioning

confidence: 99%

Silk fibroin scaffolds: A promising candidate for bone regeneration

Lin²,

Zhao³

et al. 2022

Front. Bioeng. Biotechnol.

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“…Fibers, foams, films, meshes, coatings, and hydrogels made from recombinant spider silk have shown promising features for applications in fields ranging from protein immobilization, cell culture scaffolds, tissue engineering, and drug release systems, all of which are reviewed elsewhere. 371,372 In summary, artificial spider silk fibers have great potential as sustainable alternatives to traditional polymer fibers and materials. In the past decade, significant progress has been made to bring this material into industrial use and by continuing to develop biotechnological tools for heterologous protein production, to advance study on native silk formation and to develop biomimetic spinning processes so that they align to the needs of the fiber industry, bulk-scale production of high-performance, biomimetic, and sustainable fiber should be attainable in the not so distant future.…”

Section: Bioinspired Materials Fabricationmentioning

confidence: 99%

Biological Materials Processing: Time-Tested Tricks for Sustainable Fiber Fabrication

Rising

Harrington

2022

Chem. Rev.

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There is an urgent need to improve the sustainability of the materials we produce and use. Here, we explore what humans can learn from nature about how to sustainably fabricate polymeric fibers with excellent material properties by reviewing the physical and chemical aspects of materials processing distilled from diverse model systems, including spider silk, mussel byssus, velvet worm slime, hagfish slime, and mistletoe viscin. We identify common and divergent strategies, highlighting the potential for bioinspired design and technology transfer. Despite the diversity of the biopolymeric fibers surveyed, we identify several common strategies across multiple systems, including: (1) use of stimuliresponsive biomolecular building blocks, (2) use of concentrated fluid precursor phases (e.g., coacervates and liquid crystals) stored under controlled chemical conditions, and (3) use of chemical (pH, salt concentration, redox chemistry) and physical (mechanical shear, extensional flow) stimuli to trigger the transition from fluid precursor to solid material. Importantly, because these materials largely form and function outside of the body of the organisms, these principles can more easily be transferred for bioinspired design in synthetic systems. We end the review by discussing ongoing efforts and challenges to mimic biological model systems, with a particular focus on artificial spider silks and mussel-inspired materials.

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“…Superhydrophobic organisms, [1][2][3] such as lotus leaves, [4][5][6] water strider, [7][8][9] rose petals, 10,11 butterfly wings, 12,13 rice leaves, 14 and taro leaves, 15 among others, [16][17][18][19] exist in nature. Benefitting from their strong water-repellency, these natural creatures survive perfectly in the surrounding environment.…”

Section: Introductionmentioning

confidence: 99%