A Review of Tissue Substitutes for Ultrasound Imaging

Culjat, Martin O.; Goldenberg, David M.; Tewari, Priyamvada; Singh, Rahul

doi:10.1016/j.ultrasmedbio.2010.02.012

Cited by 538 publications

(410 citation statements)

References 93 publications

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“…Copolymer-in-oil TMM phantoms can achieve optimal mechanical properties (Oudry et al, 2009); however, the range of acoustic velocities achievable with this material (1420 -1464 m/s) is much lower than that of soft tissue (Szabo, 2004). Polyarcylamide gel requires special precautions during preparation due to its toxicity (Culjat et al, 2010), and in addition the material has been reported as fragile (Oudry et al, 2009). …”

Section: Introductionmentioning

confidence: 99%

Assessment of the accuracy of an ultrasound elastography liver scanning system using a PVA-cryogel phantom with optimal acoustic and mechanical properties

Cournane¹,

Cannon²,

Browne³

et al. 2010

Phys. Med. Biol.

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The accuracy of a transient elastography liver-scanning ultrasound system was assessed using a novel application of PVA-cryogel as a tissue-mimicking material with acoustic and shear elasticity properties optimized to best represent those of liver tissue. Although the liver-scanning system has been shown to offer a safer alternative for diagnosing liver cirrhosis through stiffness measurement, as compared to the liver needle biopsy exam, the scanner's accuracy has not been fully established. The Young's elastic modulus values of 5-6wt% PVA-cryogel phantoms, also containing glycerol and 0.3μm Al 2 O 3 and 3μm Al 2 O 3 , were measured using a 'gold standard' mechanical testing technique and transient elastography. The mechanically measured values and acoustic velocities of the phantoms ranged between 1.6-16.1kPa and 1540-1570m/s, respectively, mimicking those observed in liver tissue. The values reported by the transient elastography system overestimated the Young's elastic modulus values representative of the progressive stages of liver fibrosis by up to 32%. These results were attributed to the relative rather than absolute nature of the measurement arising from the singlepoint acoustic velocity calibration of the system, rendering the measurements critically dependent on the speed of sound of the sample under investigation. Given the wide range of acoustic velocities which exist in the liver, spanning healthy tissue to cirrhotic pathology, coupled with the system's assumption that the liver is approximately elastic when it is rather highly viscoelastic, care should be exercised when interpreting the results from this system in patient groups.2

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Section: Introductionmentioning

confidence: 99%

Assessment of the accuracy of an ultrasound elastography liver scanning system using a PVA-cryogel phantom with optimal acoustic and mechanical properties

Cournane¹,

Cannon²,

Browne³

et al. 2010

Phys. Med. Biol.

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show abstract

“…Elastic properties of the material (gel) are also able to be known here as the compressibility of the material. Regarding to equation (2), an increase in elastic modulus will result in increase in the acoustic speed, compared to density because the compressibility plays more important role to determine the sound speed through media An increase in density which should leads to decrease in the propagation speed as in Figure 2 (a), actually didn't affect much of the value of the sound speed. Every five days each, the physical condition of those polymer gels was being observed while the sound speed was measured.…”

Section: Resultsmentioning

confidence: 99%

“…In the range of medical application, there are some tissues phantoms available commercially [2]. The comparison between the multipurpose manufactured phantoms such as (Zerdine TM from CIRS Inc., condensed-milk-based gel from Gammex RMI and urethane-rubber-based from ATSLabs) [3]were made, this fabricated phantom has several advantages, i.e the phantom is easily made, low cost, less fragile, and the preparation using less hazardous chemical, and can last within three weeks (23 days) based on visual inspection from the ultrasound image and direct observation.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound Speed of Polymer Gel Mimicked Human Soft Tissue within Three Weeks

Othman¹,

Jaafar²,

Rahman³

et al. 2011

IJBBB

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Abstract-A Polymer gel mimicked human soft tissue was being fabricated using a monomer named 2-Hydroxyl-Ethyl-Acrylate (HEA) with the present of gelatin. The readymade gel which is the concentration for HEA fixed at 5% was then undergoes an ultrasonic evaluation to test for the propagation of sound speed through it. Sonic Waves Analyzer is absolutely the most accurate technique to determine the aims (changes of speed as function of polymer structure /stiffness over time). The fixed frequency of transducers involved is at 500 kHz by using the seismic reflection concept. In the observation of relationship between the ultrasound propagation speeds as the day increased, the propagation speed still varies between 1390 to 1500 m/s which is still in the range of speed of sound for human tissue.Index Terms-Tissue mimicking, ultrasound phantom, abdominal ultrasound, ultrasound propagation speed

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“…The backscatter properties of the tissue‐mimicking material in the CIRS 047 are not mentioned in the specification from the manufacturer other than “scatter controlled independently from attenuation”. The backscatter coefficient is difficult to measure accurately and is therefore rarely reported in the literature (23) . Nevertheless, the amount of scatter in the phantom results in images with a soft‐tissue‐like appearance.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the low‐contrast detectability of two ultrasound systems using a grayscale phantom

Lorentsson

Hosseini

Johansson

et al. 2016

J Applied Clin Med Phys

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The purpose of the present study was to use a commercially available grayscale phantom to compare two ultrasound systems regarding their ability to reproduce clinically relevant low‐contrast objects at different sizes and depths, taking into account human observer variability and other methodological issues related to observer performance studies. One high‐end and one general ultrasound scanner from the same manufacturer using the same probe were included. The study was intended to simulate the clinical situation where small low‐contrast objects are embedded in relatively homogeneous organs. Images containing 4 and 6.4 mm objects of four different contrasts were acquired from the grayscale phantom at different depths. Six observers participated in a 4‐alternative forced‐choice study based on 960 images. Case sample and human observer variabilities were taken into account using bootstrapping. At four of sixteen depth/size/contrast combinations, the visual performance of the high‐end scanner was significantly higher. Thus, it was possible to use a grayscale phantom to discriminate between the two evaluated ultrasound systems in terms of their ability to reproduce clinically relevant low‐contrast objects. However, the number of images and number of observers were larger than those usually used for constancy control.PACS number(s): 87.57.C‐, 87.63.dh

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A Review of Tissue Substitutes for Ultrasound Imaging

Cited by 538 publications

References 93 publications

Assessment of the accuracy of an ultrasound elastography liver scanning system using a PVA-cryogel phantom with optimal acoustic and mechanical properties

Assessment of the accuracy of an ultrasound elastography liver scanning system using a PVA-cryogel phantom with optimal acoustic and mechanical properties

Ultrasound Speed of Polymer Gel Mimicked Human Soft Tissue within Three Weeks

Comparison of the low‐contrast detectability of two ultrasound systems using a grayscale phantom

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