A Review of the Structure, Preparation, and Application of NLCs, PNPs, and PLNs

Abstract

Nanostructured lipid carriers (NLCs) are modified solid lipid nanoparticles (SLNs) that retain the characteristics of the SLN, improve drug stability and loading capacity, and prevent drug leakage. Polymer nanoparticles (PNPs) are an important component of drug delivery. These nanoparticles can effectively direct drug delivery to specific targets and improve drug stability and controlled drug release. Lipid–polymer nanoparticles (PLNs), a new type of carrier that combines liposomes and polymers, have been employed in recent years. These nanoparticles possess the complementary advantages of PNPs and liposomes. A PLN is composed of a core–shell structure; the polymer core provides a stable structure, and the phospholipid shell offers good biocompatibility. As such, the two components increase the drug encapsulation efficiency rate, facilitate surface modification, and prevent leakage of water-soluble drugs. Hence, we have reviewed the current state of development for the NLCs’, PNPs’, and PLNs’ structures, preparation, and applications over the past five years, to provide the basis for further study on a controlled release drug delivery system.

Aerosol characterisation of nebulised liposomes co-loaded with erlotinib and genistein using an abbreviated cascade impactor method

“…A previous study demonstrated that the incorporation of cholesterol and DOPE into liposomes of the saturated lipid hydrogenated soybean phosphatidylcholine (HSPC) at the appropriate ratio, changed the lipid packing and fluidity of the phospholipid bilayer, resulting in improvements in the entrapment efficiency and stability of genistein-containing liposomes as compared to HSPC liposomes (Phan et al, 2013). HSPC and cholesterol have also been used in the preparation of erlotinibloaded nanocarriers (Li et al, 2017;Mandal et al, 2016). However, the coincorporation of erlotinib and genistein into liposomes has not previously been reported.…”

Advances of Nano-Structured Extended-Release Local Anesthetics

“…The two components together help inhibit water infiltration and slow hydrolysis down, and as a result prevent drug diffusion and burst leakage. Lipid shell also enhances biocompatibility of nanoparticle with similarity to cell membrane [160]; this is promising in achieving simultaneous co-delivery of multiple drugs [151,152,160]. On the other hand, polymeric core can facilitate mechanical stability, shape control, and size distribution.…”

Stimuli-Responsive Polymeric Nanosystem for Colon Specific Drug Delivery

“…103 One of the drawback of administering immunoliposomes via oral route is that Abs are easily susceptible to destruction by acidic pH of the stomach and enzymes present. 104 Also, the bilayer present in liposome gets digested by bile salts and enzymes if it has no additional protective covering. 105 The penetrative power through mucosa helps liposome to be used effectively in treating inflammation of intestinal mucosal tissue in case of IBD.…”