A review of the pleiotropic actions of the IFN-inducible CXC chemokine receptor 3 ligands in the synovial microenvironment

Dillemans, Luna; Somer, Lien De; Neerinckx, Barbara; Proost, Paul

doi:10.1007/s00018-023-04715-w

Cited by 5 publications

(2 citation statements)

References 432 publications

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“…They are secreted by leukocytes, macrophages, tumor cells and fibroblasts. They can be induced by IFN to recruit Th cells, T cells, natural killer cells to perform antiinfection and antitumor role [ 14 ]. CXCL12, known as stem cell-derived factor 1, has angiogenesis property and regulate tumor progression.…”

Section: The Structure and Function Of Cxcl Familymentioning

confidence: 99%

The role of CXCL family members in different diseases

et al. 2023

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Chemokines are a large family mediating a lot of biological behaviors including chemotaxis, tumor growth, angiogenesis and so on. As one member of this family, CXC subfamily possesses the same ability. CXC chemokines can recruit and migrate different categories of immune cells, regulate tumor’s pathological behaviors like proliferation, invasion and metastasis, activate angiogenesis, etc. Due to these characteristics, CXCL subfamily is extensively and closely associated with tumors and inflammatory diseases. As studies are becoming more and more intensive, CXCLs’ concrete roles are better described, and CXCLs’ therapeutic applications including biomarkers and targets are also deeply explained. In this review, the role of CXCL family members in various diseases is summarized.

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Section: The Structure and Function Of Cxcl Familymentioning

confidence: 99%

The role of CXCL family members in different diseases

et al. 2023

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“…Besides, the interaction between Mbm and Th_naïve in Aged_ECM also helps explain the impaired type L immnue response around the scaffold. On one hand, decreased CXCL chemotaxis pathways by Mbm correlated with lower abundance of Th_naïve cells around scaffold 58 . On the other, downregulation of MHC-II molecules and upregulation of immunosuppressive PD-L1 pathways in Mbm accounted for the reduced co-stimulatory signals and activation of Th_naïve cells 59 .…”

Section: Resultsmentioning

confidence: 99%

Integrated-omics profiling unveils the disparities of host defense to ECM scaffolds during wound healing in aged individuals

Chen,

Chu,

Wang

et al. 2023

Preprint

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Extracellular matrix (ECM) scaffold membranes have exhibited promising potential to better the outcomes of wound healing by creating a regenerative microenvironment around. However, when compared to the application in younger individuals, the performance of the same scaffold membrane in promoting re-epithelialization and collagen deposition was observed dissatisfying in aged mice. To comprehensively elucidate the mechanisms underlying this age-related disparity, we conducted an integrated analysis, combing single-cell RNA sequencing (scRNA-Seq) with spatial transcriptomics, to explore the complex cellular niches surrounding the ECM scaffolds. Through intergroup comparative analysis and cell-cell communication, we identified and characterized the senescent SPP1+ macrophages may impede the activation of the type L immune response, thus inhibiting the repair ability of epidermal cells and fibroblasts around the ECM scaffolds. These findings contribute to a deeper understanding of biomaterial applications in varied physiological contexts, thereby paving the way for the development of precision-based biomaterials tailored specifically for aged individuals in future therapeutic strategies.

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