The role of CXCL family members in different diseases

Zhou, Chenjia; Gao, Ying; Ding, Peilun; Wu, Tao; Ji, Guang

doi:10.1038/s41420-023-01524-9

Cited by 40 publications

(18 citation statements)

References 136 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chemokines are small molecules that direct specific leukocyte migration (21). Here, we evaluated CXCL1 and CXCL2 in the NT at day 14 post challenge by ELISA, as both chemokines regulate homing of neutrophils to the site of infection (22). Unimmunized and aPV immunized mice had minimally detectable amounts of CXCL1 in the NT, while wPV immunized mice had a significant increase in CXCL1 in the NT compared to naïve and aPV immunized mice ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Opposing effects of acellular and whole cell pertussis vaccines onBordetella pertussisbiofilm formation, Siglec-F+ neutrophil recruitment and bacterial clearance in mouse nasal tissues

Hall,

Gutiérrez-Ferman,

Shamseldin

et al. 2024

Preprint

View full text Add to dashboard Cite

Despite global vaccination, pertussis caused by Bordetella pertussis (Bp) is resurging. Pertussis resurgence is correlated with the switch from whole cell vaccines (wPV) that elicit TH1/TH17 polarized immune responses to acellular pertussis vaccines (aPV) that elicit primarily TH2 polarized immune responses. One explanation for the increased incidence in aPV-immunized individuals is the lack of bacterial clearance from the nose. To understand the host and bacterial mechanisms that contribute to Bp persistence, we evaluated bacterial localization and the immune response in the nasal associated tissues (NT) of naïve and immunized mice following Bp challenge. Bp resided in the NT of unimmunized and aPV-immunized mice as biofilms. In contrast, Bp biofilms were not observed in wPV-immunized mice. Following infection, Siglec-F+ neutrophils, critical for eliminating Bp from the nose, were recruited to the nose at higher levels in wPV immunized mice compared to aPV immunized mice. Consistent with this observation, the neutrophil chemokine CXCL1 was only detected in the NT of wPV immunized mice. Importantly, the bacteria and immune cells were primarily localized within the NT and were not recovered by nasal lavage (NL). Together, our data suggest that the TH2 polarized immune response generated by aPV vaccination facilitates persistence in the NT by impeding the infiltration of immune effectors and the eradication of biofilms In contrast, the TH1/TH17 immune phenotype generated by wPV, recruits Siglec-F+ neutrophils that rapidly eliminate the bacterial burden and prevent biofilm establishment. Thus, our work shows that aPV and wPV have opposing effects on Bp biofilm formation in the respiratory tract and provides a mechanistic explanation for the inability of aPV vaccination to control bacterial numbers in the nose and prevent transmission.

show abstract

Section: Resultsmentioning

confidence: 99%

Opposing effects of acellular and whole cell pertussis vaccines onBordetella pertussisbiofilm formation, Siglec-F+ neutrophil recruitment and bacterial clearance in mouse nasal tissues

Hall,

Gutiérrez-Ferman,

Shamseldin

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…These results imply that formation of a pro-tumorigenic lung microenvironment induced by radiation depends on the functions of macrophages rather than T cells. A cytokine array analysis further identi ed elevated levels of P-selectin, TSP-1, CXCL7, CXCL14, and CXCL2 in irradiated lung tissues, all of which are known to be associated with increased in ltration of monocyte-derived macrophages [29][30][31] (Fig. 3C).…”

Section: Induction Of Lung Brosis By Radiotherapy Via Macrophage In L...mentioning

confidence: 96%

Prevention of radiotherapy-induced pro-tumorigenic microenvironment by SFK-inhibitors

Kang,

Choi,

Kim

et al. 2024

Preprint

View full text Add to dashboard Cite

Radiotherapy is a widely employed technique for eradication of tumor using high-energy beams, and has been applied to approximately 50% of all solid tumor patients. However, its non-specific, cell-killing property leads to inevitable damage to surrounding normal tissues. Recent findings suggest that radiotherapy-induced tissue damage contributes to the formation of a pro-tumorigenic microenvironment. Here, we utilized mouse models to uncover the mechanisms underlying the development of such a radiation-triggered microenvironment. Radiotherapy-induced tissue damage stimulates infiltration of monocyte-derived macrophages and their differentiation into M2 macrophages, ultimately leading to fibrosis and the formation of a pro-tumorigenic microenvironment. This phenomenon was consistently observed across two mouse strains and two organ-targeted radiotherapy models. Notably, SRC family kinases (SFKs) emerged as crucial factors in the formation of the radiotherapy-induced pro-tumorigenic microenvironment. SFKs activation in epithelial cells and fibroblasts was triggered by direct exposure to irradiation or M2 macrophage cytokines. Remarkably, the administration of SFK-targeted inhibitors reversed myofibroblast activation, effectively ameliorating fibrosis and the pro-tumorigenic microenvironment in radiated tissues. Further, combined administration of radiotherapy and SFK-targeted inhibitors significantly enhanced the survival of tumor-bearing mice. In conclusion, reshaping of the tissue microenvironment by SFK-targeting is a potential strategy for prevention of metastasis and recurrence following radiotherapy.

show abstract

“…The genes affected were further analyzed for their role in physiological processes, including host inflammation and cancer signaling pathways. It was discovered that B. burgdorferi actively alters cellular responses to favor pathways associated with inflammation and tumor progression [ 23 ]. One of the major findings from this study was that several members of the C-X-C motif chemokine family, especially CXCL8 and CXCL 10 were highly elevated after B. burgdorferi infection [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

“…One of the major findings from this study was that several members of the C-X-C motif chemokine family, especially CXCL8 and CXCL 10 were highly elevated after B. burgdorferi infection [ 22 ]. The CXCL8 protein, also known as interleukin 8 (IL-8), is secreted by cells of the innate immune system and serves as a chemoattractant to recruit neutrophils [ 23 ]. CXCL10, on the other hand, exerts its functions through its receptor CXCR3, inducing pleiotropic effects such as the stimulation of NK cells, monocytes, and T-cell migration.…”

Section: Introductionmentioning

confidence: 99%

“…CXCL10, on the other hand, exerts its functions through its receptor CXCR3, inducing pleiotropic effects such as the stimulation of NK cells, monocytes, and T-cell migration. It also serves as a key regulatory factor in the context of the ‘cytokine storm’ [ 23 ]. The importance of these findings warrants additional investigation into the presence of B. burgdorferi within cancer tissues to explore deeper into the underlying processes.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evidence for the presence of Borrelia burgdorferi in invasive breast cancer tissues

Patel,

Thippani,

Jathan

et al. 2024

EuJMI

View full text Add to dashboard Cite

Borrelia burgdorferi, the causative agent of Lyme disease, has recently been demonstrated to infect and enhance the invasive properties of breast cancer cells, while also influencing the expression of inflammatory chemokines (CXCL8 and CXCL10). This study investigates the presence of B. burgdorferi in invasive breast cancer tissues using commercially available, FDA-approved breast cancer tissue microarrays consisting of 350 ductal, 32 lobular, and 22 intraductal invasive breast carcinomas, alongside 29 normal breast tissues. Employing fluorescent immunohistochemical staining and high-resolution imaging, the findings revealed that approximately 20% of invasive lobular and ductal carcinomas, followed by 14% of intraductal carcinomas, tested positive for B. burgdorferi, while all normal breast tissues tested negative. PCR analysis further confirmed the presence of B. burgdorferi DNA in breast cancer tissues. Moreover, 25% of B. burgdorferi-positive tissues exhibited expression of both chemokines, CXCL8 and CXCL10, which was not observed in B. burgdorferi-negative tissues. Analysis of available patient data, including age, indicated a correlation between older patients and B. burgdorferi-positive tissues. This study validates the presence of B. burgdorferi in invasive breast cancer tissues and highlights the involvement of key CXCL family members associated with inflammatory processes.

show abstract

The role of CXCL family members in different diseases

Cited by 40 publications

References 136 publications

Opposing effects of acellular and whole cell pertussis vaccines onBordetella pertussisbiofilm formation, Siglec-F+ neutrophil recruitment and bacterial clearance in mouse nasal tissues

Opposing effects of acellular and whole cell pertussis vaccines onBordetella pertussisbiofilm formation, Siglec-F+ neutrophil recruitment and bacterial clearance in mouse nasal tissues

Prevention of radiotherapy-induced pro-tumorigenic microenvironment by SFK-inhibitors

Evidence for the presence of Borrelia burgdorferi in invasive breast cancer tissues

Contact Info

Product

Resources

About