A Review of the Pharmacological Efficacy and Safety of Licorice Root from Corroborative Clinical Trial Findings

Kwon, Yu‐Jin; Son, Da‐Hye; Chung, Tae-Ha; Lee, Yong-Jae

doi:10.1089/jmf.2019.4459

Cited by 114 publications

(79 citation statements)

References 82 publications

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“…Since the publication of the EMA’s assessment report, numerous further clinical trials have been conducted. A recent review by Kwon et al [ 253 ] summarizes study results related to liver, gastrointestinal, oral, skin and metabolic disorders which confirm licorice’s anti-inflammatory, antioxidant, and immunomodulatory properties. However, the authors caution against chronic use, especially in patients with cardiovascular comorbidities due to the mineralocorticoid-like effect of glycyrretinic acid and GS-induced pseudoaldosteronism.…”

Section: Resultsmentioning

confidence: 99%

The Role of Adaptogens in Prophylaxis and Treatment of Viral Respiratory Infections

Panossian¹,

Brendler

2020

Pharmaceuticals

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The aim of our review is to demonstrate the potential of herbal preparations, specifically adaptogens for prevention and treatment of respiratory infections, as well as convalescence, specifically through supporting a challenged immune system, increasing resistance to viral infection, inhibiting severe inflammatory progression, and driving effective recovery. The evidence from pre-clinical and clinical studies with Andrographis paniculata, Eleutherococcus senticosus, Glycyrrhiza spp., Panax spp., Rhodiola rosea, Schisandra chinensis, Withania somnifera, their combination products and melatonin suggests that adaptogens can be useful in prophylaxis and treatment of viral infections at all stages of progression of inflammation as well as in aiding recovery of the organism by (i) modulating innate and adaptive immunity, (ii) anti-inflammatory activity, (iii) detoxification and repair of oxidative stress-induced damage in compromised cells, (iv) direct antiviral effects of inhibiting viral docking or replication, and (v) improving quality of life during convalescence.

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Section: Resultsmentioning

confidence: 99%

The Role of Adaptogens in Prophylaxis and Treatment of Viral Respiratory Infections

Panossian¹,

Brendler

2020

Pharmaceuticals

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“…In biology and medicine, GLR has been extensively studied for its very diverse pharmacological properties, including antiinflammatory, antioxidative, anti-allergenic, antimicrobial, antiviral, antiparasite, anticancer properties. The properties and applications of GLR and GLR-containing extracts have been reviewed previously (Chen, Yang, Shen, & Zhu, 2019;El-Saber Batiha, Magdy Beshbishy, El-Mleeh, Abdel-Daim, & Prasad, 2020;Kwon, Son, Chung, & Lee, 2020;Ming & Yin, 2013). Nevertheless, in view of the increasing scientific interest in this product and the current COVID-19 pandemia, we decided to write a review essentially focus on the antiviral properties of the drug, to analyze its potential use for the treatment of coronavirus infections.…”

Section: Glycyrrhizin (Glr) a Natural Productmentioning

confidence: 99%

“…Its clinical use is increasing. In recent years, we noted the development of different clinical trials to investigate the benefit of GLR in multiple pathologies such as depression (Cao et al, 2020), Parkinson's disease (Petramfar, Hajari, Yousefi, Azadi, & Hamedi, 2020) and different cancers, such as hepatocellular carcinoma and pancreatic cancer (Kwon et al, 2020).…”

Section: Glr As a Drug Used In Humanmentioning

confidence: 99%

Glycyrrhizin: An alternative drug for the treatment of COVID-19 infection and the associated respiratory syndrome?

Bailly

Vergoten

2020

Pharmacology & Therapeutics

246

205

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Safe and efficient drugs to combat the current COVID-19 pandemic are urgently needed. In this context, we have analyzed the anti-coronavirus potential of the natural product glycyrrhizic acid (GLR), a drug used to treat liver diseases (including viral hepatitis) and specific cutaneous inflammation (such as atopic dermatitis) in some countries. The properties of GLR and its primary active metabolite glycyrrhetinic acid are presented and discussed. GLR has shown activities against different viruses, including SARS-associated Human and animal coronaviruses. GLR is a non-hemolytic saponin and a potent immuno-active anti-inflammatory agent which displays both cytoplasmic and membrane effects. At the membrane level, GLR induces cholesterol-dependent disorganization of lipid rafts which are important for the entry of coronavirus into cells. At the intracellular and circulating levels, GLR can trap the high mobility group box 1 protein and thus blocks the alarmin functions of HMGB1. We used molecular docking to characterize further and discuss both the cholesterol-and HMG boxbinding functions of GLR. The membrane and cytoplasmic effects of GLR, coupled with its long-established medical use as a relatively safe drug, make GLR a good candidate to be tested against the SARS-CoV-2 coronavirus, alone and in combination with other drugs. The rational supporting combinations with (hydroxy)chloroquine and tenofovir (two drugs active against SARS-CoV-2) is also discussed. Based on this analysis, we conclude that GLR should be further considered and rapidly evaluated for the treatment of patients with COVID-19.

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“…In one case patient was combining licorice with the glucocorticoid medication fludrocortisone [55]. The active components of licorice, glycyrrhizinates, inhibit the enzyme responsible for inactivating cortisol and bind to mineralocorticoid receptors resulting in reversible hyper-mineralocorticoid effects [56]. A meta-analysis with 18 clinical trials found that chronic daily intake of 100 mg glycyrrhizin increases systolic and diastolic blood pressure [57].…”

Section: Licorice In Heart Diseasementioning

confidence: 99%

Safety Review of Herbs and Supplements in Heart Disease, Diabetes, and COVID-19

Vieira-Brock¹

2022

Natural Medicinal Plants

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Usage of supplements has increased dramatically this last decade. From herbs to vitamins and mineral, consumers are interested in improving health, self-treatment and preventing diseases. Often using information from the internet to self-prescribe, many consumers believe that natural products are safe, while many others avoid using these products because of the lack of an approval process by health officials in many countries. Herbs and other supplements including proteins, vitamins and minerals provide significant benefits to health. The lack of guidance from health professionals however can be problematic. When combined with drugs and disease, herbs can interact and cause side effects. Some of the steps to evaluate the safe use of supplements is to know their mechanism of action, clinical effect, and consumers’ medical history. For example, an herb that induces liver enzymes will reduce the effect of a drug that is metabolized by these same enzymes. This can be life threating if the patient depends on this drug for normal function. Based on drug-herb interaction experience and literature review, this book chapter provides insights into safe use of echinacea, licorice, turmeric, and black seed in patients with heart disease, diabetes, and COVID-19.

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A Review of the Pharmacological Efficacy and Safety of Licorice Root from Corroborative Clinical Trial Findings

Cited by 114 publications

References 82 publications

The Role of Adaptogens in Prophylaxis and Treatment of Viral Respiratory Infections

The Role of Adaptogens in Prophylaxis and Treatment of Viral Respiratory Infections

Glycyrrhizin: An alternative drug for the treatment of COVID-19 infection and the associated respiratory syndrome?

Safety Review of Herbs and Supplements in Heart Disease, Diabetes, and COVID-19

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