A Review of the Literature on the Management of Silicone Implant Incompatibility Syndrome

Fuzzard, Sibon K; Teixeira, Rodrigo P; Zinn, Richard

doi:10.1007/s00266-019-01407-4

Cited by 18 publications

(10 citation statements)

References 31 publications

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“… 44 D4 Cyclic siloxane Material Andreou et al [ 136 ]: unusual constriction of the isolated sciatic nerve, death of nerve fibers. 45 D5 Cyclic siloxane Fuzzard et al [ 137 ]: due to silicone implants, myalgias, chronic fatigue, cognitive impairment. 46 D6 Cyclic siloxane 47 Daidzein Isoflavones Yu et al [ 138 ]: perinatal exposure enhances estrogen receptor alpha expression in several brain regions such as stria terminalis, arcuate hypothalamic nucleus, and central amygdaloid nucleus.…”

Section: Resultsmentioning

confidence: 99%

Endocrine disruptors also function as nervous disruptors and can be renamed endocrine and nervous disruptors (ENDs)

Séralini

Jungers

2021

Toxicology Reports

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Section: Resultsmentioning

confidence: 99%

Endocrine disruptors also function as nervous disruptors and can be renamed endocrine and nervous disruptors (ENDs)

Séralini

Jungers

2021

Toxicology Reports

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“…In the case of positive history or immunological markers, rheumatology assessment is confirmed and the follow-up consists of ultrasound once a year, MRI after 5 and 10 years and immunological markers in the first year and every two years for 10 years. 24 Fuzzard et al published a literature review where they suggest an algorithm that begins with a clear informed consent process and identification of risk factors for SIIS development prior to implantation. Subsequently, if SIIS develops, they advocate early multidisciplinary input.…”

Section: Discussionmentioning

confidence: 99%

Autoimmune / Inflammatory Syndrome Induced by Adjuvants (Asia Syndrome) Associated with Silicone Breast Implant Rupture

Santiago¹,

Paula²

2021

Arch Breast Cancer

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Background: Autoimmune/inflammatory syndrome (ASIA) constitutes a set of related immune mediated diseases that share a common clinical picture and a history of a previous exposure to an adjuvant agent. From a clinical standpoint, patients present with none specific manifestations such as myalgia, arthralgia, chronic fatigue and dry mouth as well as neurological manifestations such as cognitive disturbances, memory loss and neurologic disabilities. .Case presentation: A previously healthy 25-year-old patient who underwent breast augmentation 3 years ago, with an asymptomatic rupture of the silicone breast implant, presented with three major criteria of ASIA, and improved after bilateral implant removal. She also had pleuritis and pericarditis, rarely described in such disease. A literature review on complications related to breast implants, their questionable relationship to the onset of autoimmune pathologies, and basic aspects of the diagnosis and management of ASIA was carried out. Conclusion: The silicone presented in breast implants should be considered as an adjuvant, with the potential to cause chronic stimulation to the immune system. This can lead to systemic manifestations that can be severe in patients genetically predisposed and potentially not reversible even after surgical removal of the implants. When facing patients with breast implants and systemic clinical symptoms, lymph node disorders, neurological manifestations, or serositis as in the case presented, without other defined etiology, the possibility of ASIA should be considered in the differential diagnosis.

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“…B. Myalgie, Arthralgien, eine chronische Fatigue, Schlafstörungen und/oder Beeinträchtigung der kognitiven Fähigkeiten, aber auch direkte kutane Veränderungen im Bereich der eingebrachten Implantate. Therapeutisch kommt eine Entfernung der/des Implantate(s) oder eine immunsuppressive Therapie in Betracht [12].…”

Section: Brustimplantatassoziiertes Anaplastisches Großzelliges Lymphunclassified

Implantate der weiblichen Brust – Teil 3: Malignome

Fischer¹,

Said

2021

Senologie - Zeitschrift für Mammadiagnostik und -therapie

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ZusammenfassungHinsichtlich der bösartigen Tumoren muss bei Frauen mit Implantaten unterschieden werden zwischen dem extrem seltenen Krankheitsbild des anaplastisch großzelligen Lymphoms (ALCL) einerseits und dem herkömmlichen Brustkrebs andererseits. Während das brustimplantatinduzierte BIA-ALCL in aller Regel bereits anhand der nicht kontrastmittelgestützten Protokolle zu diagnostizieren ist, bedarf es für den Nachweis insbesondere kleinerer Mammakarzinome der Applikation eines Kontrastmittels. Es kommen dabei dynamische Protokolle zum Einsatz, die eine Visualisierung der Durchblutung der intramammären Strukturen ermöglichen. Bei der Verwendung qualitätsgesicherter, hoch aufgelöster Untersuchungen erweist sich die Mamma-MRT im Nachweis insbesondere des kleinen Mammakarzinoms allen anderen bildgebenden Verfahren überlegen. Im letzten Teil der dreiteiligen Präsentation werden das ALCL und kleine Mammakarzinome bei Frauen mit Implantaten unter besonderer Berücksichtigung der MRT präsentiert.

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A Review of the Literature on the Management of Silicone Implant Incompatibility Syndrome

Cited by 18 publications

References 31 publications

Endocrine disruptors also function as nervous disruptors and can be renamed endocrine and nervous disruptors (ENDs)

Endocrine disruptors also function as nervous disruptors and can be renamed endocrine and nervous disruptors (ENDs)

Autoimmune / Inflammatory Syndrome Induced by Adjuvants (Asia Syndrome) Associated with Silicone Breast Implant Rupture

Implantate der weiblichen Brust – Teil 3: Malignome

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