A review of the impact of xenobiotics from dietary sources on infant health: Early life exposures and the role of the microbiota

Calatayud, Marta; García-Barrera, Tamara; Callejón‐Leblic, Belén; Arias-Borrego, Ana; Collado, María Carmen

doi:10.1016/j.envpol.2020.115994

Cited by 22 publications

(10 citation statements)

References 131 publications

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“…A review by Calatayud Arroyo et al [1] described the interplay between the micro biota of the mother and the child-xenobiotics-as well as diet during pregnancy and i the perinatal period. Maternal exposure to metals, persistent organic substances, and foo In addition to the human placenta [59], MPs have also been detected in children's stool [62], but the sources of these plastics are relatively difficult to detect.…”

Section: Sources Of Exposure To Microplasticsmentioning

confidence: 99%

“…It is estimated that by 2040, about 250 million metric tons of plastic waste will enter the water system and about 460 million metric tons will enter the soil system. It is very difficult to imagine life without plastics, which have become part of our everyday life [ 1 ]. They are used in a lot of applications related to packaging, the automotive industry, aquaculture, fisheries, agriculture, building, furniture, transportation, personal care products, textiles, clothing, etc.…”

Section: Introductionmentioning

confidence: 99%

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An Overview of the Possible Exposure of Infants to Microplastics

Mišľanová,

Valachovičová,

Slezáková

2024

Life

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Microplastics are small plastic pieces with sizes less than 5 mm. They are becoming a global concern due to the potential risk to human health. The potential risks of microplastics may be greater for infants because they do not have sufficiently developed metabolizing enzymes, have less ability to remove microplastics, and have highly sensitive target organs. Infants should be breastfed for the first six months of life. Breast milk is considered to be the most complete and suitable source of nutrition. However, if breastfeeding during this period is not possible, it is necessary to use formulas designed for infant initial feeding. Infants may be exposed to higher levels of MPs through infant foods or plastic products. The aim of this study is to describe the possible sources of exposure to microplastics such as the human placenta, plastic feeding bottles, and toys as well as the presence of released microplastics in infant feces, breast milk, and infant formulas. There is still not enough data available for this study area. Therefore, it is necessary to pay increased attention to minimizing the negative effects of microplastics on human health.

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Section: Sources Of Exposure To Microplasticsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An Overview of the Possible Exposure of Infants to Microplastics

Mišľanová,

Valachovičová,

Slezáková

2024

Life

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“…Finally, EDCs concentrations in the human body, which depend on individual factors, environmental parameters related to diet, indoor and outdoor exposure, have an effect on the human microbiome ( 9 , 11 , 18 , 19 ) also affecting immunity.…”

Section: Introductionmentioning

confidence: 99%

Current knowledge on the effects of environmental contaminants in early life nutrition

et al. 2023

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Breast milk represents the optimal source of feeding for newborns, in terms of nutritional compounds and as it provides immunological, metabolic, organic, and neurological well-being. As a complex biological fluid, it consists not only of nutritional compounds but also contains environmental contaminants. Formulas through production, contact with bottles and cups, and complementary feeding can also be contaminated. The current review focuses on endocrine-disrupting chemicals, and made-man xenoestrogens present in the environment and both commonly present in food sources, agricultural practices, packaging, consumer products, industry, and medical care. These contaminants are transferred by passive diffusion to breast milk and are delivered during breastfeeding. They mainly act by activating or antagonizing hormonal receptors. We summarize the effects on the immune system, gut microbiota, and metabolism. Exposure to endocrine-disrupting chemicals and indirect food additives may induce tissue inflammation and polarize lymphocytes, increase proinflammatory cytokines, promote allergic sensitization, and microbial dysbiosis, activate nuclear receptors and increase the incidence of allergic, autoimmune, and metabolic diseases. Breast milk is the most important optimal source in early life. This mini-review summarizes current knowledge on environmental contaminants and paves the way for strategies to prevent milk contamination and limit maternal and infant exposure during pregnancy and the first months of life.

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“…Especially relevant is the study of potential health effects and risk assessment in sensitive populations like infants. Infants are especially sensitive to xenobiotic exposures due to immaturity of some metabolic functions, larger surface area (relative to body weight), the high sensitivity of target organs (windows of susceptibility) and cumulative effects due to longer exposure times, putting them at a higher level of risk compared to adults (Calatayud Arroyo et al, 2021). The process of colonization and development of gut microbiota in early life has been previously linked to adult diseases, including immune and metabolic disorders, such as asthma, eczema, inflammatory bowel disease, type 1 diabetes or obesity (Zhuang et al, 2019), and our understanding on how environmental xenobiotic exposures might influence these processes is still in its infancy.…”

Section: Introductionmentioning

confidence: 99%

Alterations in infant gut microbiome composition and metabolism after exposure to glyphosate and Roundup and/or a spore-based formulation using the SHIME technology

et al. 2022

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Despite extensive research into the toxicology of the herbicide glyphosate, there are still major unknowns regarding its effects on the human gut microbiome. We describe the effects of glyphosate and a Roundup glyphosate-based herbicide on infant gut microbiota using SHIME technology. SHIME® microbiota culture was undertaken in the presence of a concentration of 100 mg/L glyphosate and the same glyphosate equivalent concentration of Roundup. Roundup and to a lesser extent glyphosate caused an increase in fermentation activity, resulting in acidification of the microbial environment. This was also reflected by an increase in lactate and acetate production concomitant to a decrease in the levels of propionate, valerate, caproate and butyrate. Ammonium production reflecting proteolytic activities was increased by Roundup exposure. Global metabolomics revealed large scale disturbances, including an increased abundance of long chain polyunsaturated fatty acids. Changes in bacterial composition measured by qPCR and 16S rRNA suggested that lactobacilli had their growth stimulated as a result of microenvironment acidification. Cotreatment with the spore-based probiotic formulation MegaSporeBiotic reverted some of the

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A review of the impact of xenobiotics from dietary sources on infant health: Early life exposures and the role of the microbiota

Cited by 22 publications

References 131 publications

An Overview of the Possible Exposure of Infants to Microplastics

An Overview of the Possible Exposure of Infants to Microplastics

Current knowledge on the effects of environmental contaminants in early life nutrition

Alterations in infant gut microbiome composition and metabolism after exposure to glyphosate and Roundup and/or a spore-based formulation using the SHIME technology

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