A review of the epidemiologic evidence concerning the reproductive health effects of caffeine consumption: A 2000–2009 update

Peck, Jennifer D.; Leviton, Alan; Cowan, Linda D.

doi:10.1016/j.fct.2010.06.019

Cited by 103 publications

(94 citation statements)

References 134 publications

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“…Nevertheless, in Greenwood et al's study higher maternal caffeine intake was associated with a higher risk of late miscarriage and stillbirth even after adjustment for salivary cotinine, a biomarker for smoking (47) . Pregnancy symptoms including nausea, vomiting, and aversions to smells and taste are more common in healthy pregnancies than in pregnancies that end in spontaneous abortion (17) . Women with viable pregnancies may be more likely to decrease their caffeine consumption in response to pregnancy symptoms (17) .…”

Section: Discussionmentioning

confidence: 99%

“…However, our results should be interpreted with caution in consideration of methodological limitations of the original studies and other potential issues such as residual confounding and publication bias that may have influenced our results. Most previous reviews on maternal caffeine intake and pregnancy loss included only a qualitative summary of the evidence (17,48,49) , used estimates that were not adjusted for potential confounders (50) or included only five studies on preconception caffeine intake (51) . A recent meta-analysis reported significant associations stronger than those observed in our meta-analysis between higher maternal caffeine intakes and higher risks of miscarriage (summary RR = 1·14 per 100 mg caffeine/d, 95 % CI 1·10, 1·19 in that study compared with 1·08, 95 % CI 1·04, 1·13 in our study) and stillbirth (summary RR = 1·19, 95 % CI 1·05, 1·35 in that study compared with 1·09, 95 % CI 1·02, 1·16 in our study) (18) .…”

Section: Discussionmentioning

confidence: 99%

“…Considerable inconsistency exists in the literature concerning the relationship of maternal caffeine intake and pregnancy loss (17) . While high maternal caffeine intakes were more consistently associated with a higher risk of pregnancy loss, results have been mixed for moderate and low caffeine use, probably due to difficulties in measuring caffeine intakes and differences in study settings and participants.…”

mentioning

confidence: 99%

“…The possible harmful effects of caffeine intake on fetal and birth outcomes warrant evaluation as many women consume caffeine-containing foods and beverages during pregnancy (4,16,17) . Considerable inconsistency exists in the literature concerning the relationship of maternal caffeine intake and pregnancy loss (17) .…”

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confidence: 99%

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Maternal caffeine intake during pregnancy and risk of pregnancy loss: a categorical and dose–response meta-analysis of prospective studies

Chen

Neelakantan

et al. 2015

Public Health Nutr.

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Objective: To assess the association between maternal caffeine intake and risk of pregnancy loss using a systematic review and meta-analysis. Design: Categorical and dose-response meta-analysis of prospective studies. Setting: Relevant articles were identified by searching MEDLINE and SCOPUS databases through 30 January 2015. Two authors independently extracted information from eligible studies. Random-effects models were used to derive the summary relative risks (RR) and corresponding 95 % CI for specific categories of caffeine consumption and for a continuous association using generalized leastsquares trend estimation. Subjects: A total of 130 456 participants and 3429 cases in fourteen included studies. Results: Compared with the reference category with no or very low caffeine intake, the RR (95 % CI) of pregnancy loss was 1·02 (0·85, 1·24; I 2 = 28·3 %) for low intake (50-149 mg/d), 1·16 (0·94, 1·41; I 2 = 49·6 %) for moderate intake (150-349 mg/d), 1·40 (1·16, 1·68; I 2 = 18·6 %) for high intake (350-699 mg/d) and 1·72 (1·40, 2·13; I 2 = 0·0 %) for very high intake (≥700 mg/d). In the dose-response analysis, each 100 mg/d increment in maternal caffeine intake (~1 cup of coffee) was associated with 7 % (95 % CI 3 %, 12 %) higher risk of pregnancy loss. Our results may have been affected by publication bias, but the association remained significant for the subset of larger studies. Furthermore, adjustment for smoking and pregnancy symptoms may have been incomplete, potentially resulting in residual confounding. Conclusions: Albeit inconclusive, higher maternal caffeine intake was associated with a higher risk of pregnancy loss and adherence to guidelines to avoid high caffeine intake during pregnancy appears prudent.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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Maternal caffeine intake during pregnancy and risk of pregnancy loss: a categorical and dose–response meta-analysis of prospective studies

Chen

Neelakantan

et al. 2015

Public Health Nutr.

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“…Literature reports an increasing risk of poor semen quality with increasing coffee consumption 2 and caffeine has been implicated in a number of epidemiologic studies as a risk factor for infertility, fetal loss, and fetal growth impairment 3 . However, a literature review of human studies from 2000 to 2009 reported no positive relationship between caffeine consumption and adverse effects on fertility 4 .…”

Section: Introductionmentioning

confidence: 99%

The testis of the mice C57/BL6 offspring in adulthood have alterations due to maternal caffeine consumption

et al. 2014

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PURPOSE:To investigate the effects of the maternal caffeine consumption during pregnancy to adult male testis mice offspring. METHODS:Twenty pregnant mice were divided into control group (c) and caffeine group (cf). dams received daily saline or 20 mg/kg of caffeine subcutaneously. Male offspring were monitored daily until 13 th week. The testis were used to evaluate both the proliferation (pcna) and apoptosis (bax); leptin receptor (ob-r); aromatase; follicle stimulating hormone (fshr), luteinizing hormone (lhr) and androgen receptors (ar); steroidogenic acute regulatory protein (star); vascular endothelial growth factor (vegf) and estrogen receptors (erα and erβ) by western blotting. Serum concentrations of testosterone, estradiol and leptin were measured. RESULTS:There was a significant reduction in food intake and the body mass gain (p<0.05) in the cf ; pcna (p=0.01), fshr (p=0.02), star (p=0.0007), vegf (p=0.009), ar (p=0.03) in the cf. while an increase were note in bax (p=0.01), ob-r (p=0.02), lhr (p=0.04) and in the aromatase (p=0.03) in the cf. only erα and erβ were not changed by maternal caffeine. The serum testosterone levels in the cf offspring were 90% lower than in the c offspring (p=0.04). CONCLUSION:Maternal caffeine consumption has a role and alters the testis of the offspring in adulthood.

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Epidemiological Evidence for Maternal Prenatal Coffee and Caffeine Consumption and Miscarriage Risk

Chan

2012

Coffee

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A review of the epidemiologic evidence concerning the reproductive health effects of caffeine consumption: A 2000–2009 update

Cited by 103 publications

References 134 publications

Maternal caffeine intake during pregnancy and risk of pregnancy loss: a categorical and dose–response meta-analysis of prospective studies

Maternal caffeine intake during pregnancy and risk of pregnancy loss: a categorical and dose–response meta-analysis of prospective studies

The testis of the mice C57/BL6 offspring in adulthood have alterations due to maternal caffeine consumption

Epidemiological Evidence for Maternal Prenatal Coffee and Caffeine Consumption and Miscarriage Risk

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