A review of the biological synthesis of gold nanoparticles using fruit extracts: scientific potential and application

Timoszyk, Anna

doi:10.1007/s12034-018-1673-4

Cited by 28 publications

(10 citation statements)

References 113 publications

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“…Since the Cornus mas L. fruit extract exerts antioxidant effects, it can also be used in nanoparticulate formulas to investigate the possible improved delivery to the target tissues. Practice proved that the bioactive Cornus mas L. compounds have not only a reductive capacity but also the property to stabilize the metallic nanoparticles, blocking their agglomeration [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Gold Nanoparticles Functionalized with Bioactive Compounds from Cornus mas Fruit on Aorta Ultrastructural and Biochemical Changes in Rats on a Hyperlipid Diet—A Preliminary Study

et al. 2022

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Cornus mas L. extract (CM) presents hypolipidemic, antioxidant and anti-inflammatory activity. Gold nanoparticles (AuNPs) are considered potent delivery systems and may be used to release pharmaceutical compounds at the level of injury. In our study, we used gold nanoparticles functionalized with bioactive compounds from Cornus mas L. (AuNPsCM) in an experimental model of a high-fat diet (HFD), and we assessed their effects on aorta wall but also in the serum, as compared to Cornus mas (CM) administration. Sprague Dawley female rats were fed for 9 months with an HFD. During the last month of the experiment, we randomly allocated the animals into three groups that received, by oral gavage: saline solution, CM solution (0.158 mg/mL polyphenols) or AuNPsCM solution (260 μg Au/kg/day), while a Control group received a standard diet and saline solution. At the end of the experiment, we performed an ultrasonography of the aorta and left ventricle and a histology and transmission electron microscopy of the aorta walls; we investigated the oxidative stress and inflammation in aorta homogenates and in serum and, in addition, the lipid profile. AuNPsCM presented better effects in comparison with the natural extract (CM) on lipid peroxidation (p < 0.01) and TNF-alpha (p < 0.001) in aorta homogenates. In serum, both CM and AuNPsCM decreased the triglycerides (p < 0.001) and C-reactive protein (CM, p < 0.01; AuNPsCM, p < 0.001) and increased the antioxidant protection (p < 0.001), in comparison with the HFD group. In intima, AuNPsCM produced ultrastructural lesions, with the disorganization of intima and subendothelial connective layer, whereas CM administration preserved the intima normal aspect, but with a thinned subendothelial connective layer. AuNPsCM oral administration presented certain antioxidant, anti-inflammatory and hypolipidemic effects in an experimental model of HFD, but with a negative impact on the ultrastructure of aorta walls, highlighted by the intima disorganization.

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Section: Discussionmentioning

confidence: 99%

Effects of Gold Nanoparticles Functionalized with Bioactive Compounds from Cornus mas Fruit on Aorta Ultrastructural and Biochemical Changes in Rats on a Hyperlipid Diet—A Preliminary Study

et al. 2022

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“…Extracts of fruits have been comprehended to contain a high amount of reducing agents. For example, fruits like blueberries, blackberries, Cornus mas L., Citrullus lanatus , grape, Terminalia arjuna and Punica granatum L., comprise a high number of anthocyanins, ascorbic acid, phenolic compounds, flavonoids, saccharides and other vitamins [ 53 ]. The synthesis of NPs from fruits has an additional advantage in comparison to NPs synthesized by the biological method.…”

Section: Green Synthesis Of Nanoparticles Mediated By Fruit Extracmentioning

confidence: 99%

Fruit Extract Mediated Green Synthesis of Metallic Nanoparticles: A New Avenue in Pomology Applications

Kumar

Bhardwaj

Dhanjal

et al. 2020

IJMS

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Fruit extracts have natural bioactive molecules that are known to possess significant therapeutic potential. Traditionally, metallic nanoparticles were synthesized via chemical methods, in which the chemical act as the reducing agent. Later, these traditional metallic nanoparticles emerged as the biological risk, which prompted researchers to explore an eco-friendly approach. There are different eco-friendly methods employed for synthesizing these metallic nanoparticles via the usage of microbes and plants, primarily via fruit extract. These explorations have paved the way for using fruit extracts for developing nanoparticles, as they eliminate the usage of reducing and stabilizing agents. Metallic nanoparticles have gained significant attention, and are used for diverse biological applications. The present review discusses the potential activities of phytochemicals, and it intends to summarize the different metallic nanoparticles synthesized using fruit extracts and their associated pharmacological activities like anti-cancerous, antimicrobial, antioxidant and catalytic efficiency.

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“…Besides, nanogold can inhibit the oxidative damage of DNA, protein and lipids through a mechanism as a radical scavenger or free radical scavenger [32]. Nanogold has been shown to have the ability to interact with cells or tissues, the metabolic system that cannot cause toxicity, injury or immune reactions when working at a specific site (biocompatibility) [33] and low cytotoxicity. Thus, it is safe to use for medicinal and diagnostic purposes [24].…”

Section: Resultsmentioning

confidence: 99%

The Effect of Nanogold-Nanosilver to Boost Immunity in People Affected (Reactive and Positive) by Covid-19

Izzah¹

2021

ijcsrr

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COVID-19 virus outbreak was first found in Wuhan China. The current COVID-19 is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (Sars-CoV-2). The interaction of the virus with the immune system causes the immunity of people affected by the outbreak to decrease. The combination of nanogold and nanosilver, that is an antimicrobial and antiviral agent, can inhibit the replication of the COVID-19 virus an d act as drug delivery. This research aims to determine the effect of nanogold-nanosilver that can increase immunity in people who are positively affected by the COVID-19 virus. The method used in this research was quantitative descriptive by describing the effect of the nanogold-nanosilver health drink given to increasing human immunity exposed to the COVID-19 virus seen from the number of respondent cures. The respondents consumed 500 mL of health drinks containing nanogold and nanosilver compounds with a concentration of 2 ppm per day. Based on the data obtained, the combination of nanogold and nanosilver could increase the immunity of people affected by COVID-19, marked by physical changes that became healthier, fitter and negative swab test results and accelerate the healing of COVID-19 patients.

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A review of the biological synthesis of gold nanoparticles using fruit extracts: scientific potential and application

Cited by 28 publications

References 113 publications

Effects of Gold Nanoparticles Functionalized with Bioactive Compounds from Cornus mas Fruit on Aorta Ultrastructural and Biochemical Changes in Rats on a Hyperlipid Diet—A Preliminary Study

Effects of Gold Nanoparticles Functionalized with Bioactive Compounds from Cornus mas Fruit on Aorta Ultrastructural and Biochemical Changes in Rats on a Hyperlipid Diet—A Preliminary Study

Fruit Extract Mediated Green Synthesis of Metallic Nanoparticles: A New Avenue in Pomology Applications

The Effect of Nanogold-Nanosilver to Boost Immunity in People Affected (Reactive and Positive) by Covid-19

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