A review of the applications of the hydrofiber dressing with silver (Aquacel Ag&amp;reg;) in wound care

Barnea, Yoav; Weiss, Jerry; Gur, Eyal

doi:10.2147/tcrm.s3462

Cited by 67 publications

(70 citation statements)

References 34 publications

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“…Based on the MTT data one could expect approximately 100% cell death, which was supported by light microscope pictures. This is also supported by previous work showing that silver ions are toxic to skin cells in vitro (Barnea, Weiss & Gur, 2010;Burd et al, 2007; Paddle- Ledinek, Nasa & Cleland, 2006;Poon & Burd, 2004).…”

Section: Discussionsupporting

confidence: 87%

Producing ultrapure wood cellulose nanofibrils and evaluating the cytotoxicity using human skin cells

Nordli

Chinga-Carrasco²,

Rokstad

et al. 2016

Carbohydrate Polymers

125

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 Cellulose nanofibril dispersion (50 µg/ml) did not affect the cytotoxicity or metabolic activity of Normal Human Dermal Fibroblasts and Human Epidermal Keratinocytes  Aerogels made of cellulose nanofibrils induced a reduction of metabolic activity by the fibroblasts and keratinocytes, but no significant cell death  Cytokine profiling measuring 27 cytokines revealed that the keratinocytes and fibroblasts did not induce cytokines upon direct exposure to the CNF materials. Due to the nano dimension of the CNFs, the aerogels had a high moisture-holding capacity (~7500%) 3 AbstractWood cellulose nanofibrils have been suggested as a potential wound healing material, but its utilization is limited by FDA requirements regarding endotoxin levels. In this study a method using sodium hydroxide followed by TEMPO mediated oxidation was developed to produce ultrapure cellulose nanofibrils (CNF), with an endotoxin level of 45 endotoxin units/g (EU/g) cellulose. Scanning transmission electron microscopy (S(T)EM) revealed a highly nanofibrillated structure (lateral width of 3.7±1.3 nm).Assessment of cytotoxicity and metabolic activity on Normal Human Dermal Fibroblasts and Human Epidermal Keratinocytes was done. CNF-dispersion of 50 g/ml did not affect the cells. CNF-aerogels induced a reduction of metabolic activity by the fibroblasts and keratinocytes, but no significant cell death. Cytokine profiling revealed no induction of the 27 cytokines tested upon exposure to CNF. The moisture-holding capacity of aerogels was relatively high (~7500%), compared to a commercially available wound dressing (~2500%),indicating that the CNF material is promising as dressing material for management of wounds with a moderate to high amount of exudate.

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Section: Discussionsupporting

confidence: 87%

Producing ultrapure wood cellulose nanofibrils and evaluating the cytotoxicity using human skin cells

Nordli

Chinga-Carrasco²,

Rokstad

et al. 2016

Carbohydrate Polymers

125

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“…This was reflected in other studies that demonstrated difficulty in joint mobility with the hardening of dressing over the joints. [6,9] In particular, the use of SSD achieved greater flexibility and ROM when compared to AQUACEL ® Ag for burn wounds. [9] Caruso et al [14] found the flexibility excellent to very good in the 82% of patients with 19% reporting average to poor flexibility.…”

Section: Flexibility and Range Of Movementmentioning

confidence: 99%

“…[4] AQUACEL ® Ag (ConvaTec, Skillman, NJ, USA) is a soft nonwoven sodium carboxymethylcellulose fiber that forms a gel and has the capacity to absorb exudate and contour to the wound bed. [4,9] Currently, there are only a few clinical studies within the peer-reviewed literature that investigate the use of the AQUACEL ® Ag BURN glove. [3,10] …”

Section: Introductionmentioning

confidence: 99%

AQUACEL^® Ag BURN glove and silver sulfadiazine for the treatment of partial thickness hand burns: A retrospective review

et al. 2016

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Background: Loss of hand function has a detrimental impact on the physical and psychosocial functioning of those with hand burns. Of prime importance is the maintenance of range of movement (ROM). Subsequently, an ideal hand dressing needs to allow for full ROM, be comfortable, and facilitate healing. However, hand burns present complex challenges for burn clinicians with the dressing of choice remaining controversial. Patients and Methods: This retrospective review was undertaken to determine the effectiveness of the AQUACEL ® Ag BURN glove as compared to silver sulfadiazine (SSD; standard care) in patients with partial thickness hand burns. The average total body surface area % was 14.6% with an average age of 37 years. Eight hands were dressed with an AQUACEL ® Ag BURN glove and eight were dressed with SSD. Results: Pain scores were reduced in those with the glove compared to those who were treated with SSD dressing. Mobility of the hand with the glove was reduced compared to the patients treated with SSD. The glove cost including outer dressings was $330 US, this is compared to $432 US for the SSD dressing based on the average reepithelization rate of 15 days, and translates into a financial saving of approximately $100 US per patient and further reduces workload and resources. Conclusion: The use of a hydrofiber silver impregnated glove for partial thickness hand burns, has clinical significance in the outpatient setting reducing the need for hospitalization, and the amount of dressing changes required.

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“…The most frequently used was chlorhexidine acetate 0.5% (Bactigrass ®), novel silver containing hydrofiber (Aquacell Aq ®), polyhexanide containing biocellulose dressing (Suprasorb ®) and polyurethane film (Omniderm ®). These burn dressing have been shown effective in superficial partial thickness and deep partial thickness (second degree) burn injuries (31)(32)(33)(34).…”

Section: Table 1 Patient Distribution and Mean Ages According To Thementioning

confidence: 99%

The Necessity of Burn Treatment Units

et al. 2013

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Aim of study to identify, describe the patterns first 950 burn patients treated in Konya Education Key words: Burn unit, burn injury, treatment of burn injury Yanık Tedavi Ünitelerinin Gerekliliği ÖZET Bu çalışmanın amacı yeni kurulanKonya Eğitim ve Araştırma Hastanesi Yanık Ünitesine yatırılaran ilk 950 yanık hastasını tanımlamaktır. Yanık yaralanması teşhisiyle Ağustos 2008 ile Eylül 2011 tarihleri arasında ünitemize yatırılarak tedavi edilenhastalar çalışmaya alındı. Hastaların bilgileri retrospektif incelendi. Cinsiyet, yaş, etyoloji, derece, hastanede yatış süresi, uygulanan konservatif, cerrahi tedavi ve tedavi maliyetleri incelendi. Toplam 38 ayda 950 hasta tedavi edildi. Erkek / kadın oranı 1,64, ortalama yaş 30,52±22,

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A review of the applications of the hydrofiber dressing with silver (Aquacel Ag®) in wound care

Cited by 67 publications

References 34 publications

Producing ultrapure wood cellulose nanofibrils and evaluating the cytotoxicity using human skin cells

Producing ultrapure wood cellulose nanofibrils and evaluating the cytotoxicity using human skin cells

AQUACEL^® Ag BURN glove and silver sulfadiazine for the treatment of partial thickness hand burns: A retrospective review

The Necessity of Burn Treatment Units

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A review of the applications of the hydrofiber dressing with silver (Aquacel Ag&reg;) in wound care

Cited by 67 publications

References 34 publications

Producing ultrapure wood cellulose nanofibrils and evaluating the cytotoxicity using human skin cells

Producing ultrapure wood cellulose nanofibrils and evaluating the cytotoxicity using human skin cells

AQUACEL® Ag BURN glove and silver sulfadiazine for the treatment of partial thickness hand burns: A retrospective review

The Necessity of Burn Treatment Units

Contact Info

Product

Resources

About

A review of the applications of the hydrofiber dressing with silver (Aquacel Ag®) in wound care

AQUACEL^® Ag BURN glove and silver sulfadiazine for the treatment of partial thickness hand burns: A retrospective review