A Review of the Application of Resorcinarenes and SBA-15 in Drug Delivery

Abstract

Due to the diseases that people face today, scientists dedicate a part of their research to the synthesis, characterization, and study of functional compounds for controlled drug delivery. On the one hand, resorcinarenes are macrocycles obtained by condensation reactions of resorcinol and aldehyde. They include an upper and a lower rim functioning with different groups that confer solubility to the macrocycle and favor interactions with other compounds, therefore the hydroxyl groups on the upper rim improve the formation of hydrogen bonds. Additionally, resorcinarenes feature a cavity studied for forming host-guest complexes. SBA-15, on the other hand, is a mesoporous silica characterized by ordered pores in its structure and a large surface area. As a result of its properties, it has been used for several purposes, including absorbents, drug delivery, catalysis, and environmental processes. This review shows the recent advances in synthesis methods, characterization, micelle formation, interaction with other compounds, and host-guest procedures, as well as techniques for evaluating toxicity, drug retention, and their preliminary uses in pharmacology for macrocycles, such as resorcin[4]arenes and SBA-15.

Synthesis of Ordered Mesoporous Silica with Nonionic Surfactant/Anionic Polyelectrolyte as Template under Near-Neutral pH Conditions

“…The interconnected pore structure is conducive to diffusion and stability . Previous studies have investigated the formation mechanism, , morphology control, , mesopore size regulation, and chemical composition adjustment (such as Ti, Al doping). , Applications of SBA-15 include catalysis, adsorption and separation, , and drug delivery …”

Amorphization of Ethenzamide and Ethenzamide Cocrystals—A Case Study of Single and Binary Systems Forming Low-Melting Eutectic Phases Loaded on/in Silica Gel

“…Another commonly used method is based on the use of mesoporous particles, which have recently gained considerable attention as a stabilizer for amorphous formulations [37][38][39]. The majority of the mesoporous particles utilized in the pharmaceutical field are mesoporous silica nanoparticles such as MCM-41 [40][41][42][43][44], Neusilin ® [45,46], UFL2 [47], Fujicalin ® [48,49], FujiSil TM [50] and SBA-15 [51][52][53].…”

Calixarene Functionalized Supramolecular Liquid Crystals and Their Diverse Applications

“…It has also been noted that some of the calixarene based functional LCs exhibit excellent mesomorphic properties with emissive behavior, columnar self-assembly, electrochemical behavior, electroluminescence, molecular switch properties, emissive gelation properties, and ion-selective behavior, respectively. Their application in ion and molecular sensing, as fluorescent probes, and as drug delivery agents has been discussed in earlier elaborate reviews. − …”

“…Their application in ion and molecular sensing, as fluorescent probes, and as drug delivery agents has been discussed in earlier elaborate reviews. 38 − 40 …”