A review of technical aspects of T1-weighted dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in human brain tumors

Bergamino, Maurizio; Bonzano, Laura; Levréro, Florence; Mancardi, Gianluigi; Roccatagliata, Luca

doi:10.1016/j.ejmp.2014.04.005

Cited by 62 publications

(53 citation statements)

References 85 publications

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“…In addition, K trans refers to the volume transfer constant between blood plasma and extravascular extracellular space (EES), representing the rate of CAs delivering to the EES, while v p refers to blood plasma volume per unit volume of tissue. [ 17 ] Herein, after the blood fl ow of the left middle cerebral artery (MCA) was cut off for 24 h, perfusion imaging of dynamic contrast enhanced MRI (DCE-MRI) of the head was performed following the intravenous injection of PEG-UCNPs or Magnevist (5 mg Gd kg −1 ) at the fl owing rate of 1 mL s −1 ( Figure 4 ). The PEG-UCNPsinjected group shows clear hypoperfused area from the perfusion maps in the left MCA territory (arrows in Figure 4 a) while the Magnevist-injected group does not.…”

Section: Resultsmentioning

confidence: 99%

High-Performance Upconversion Nanoprobes for Multimodal MR Imaging of Acute Ischemic Stroke

Wang

Zhang

et al. 2016

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Multimodal magnetic resonance (MR) imaging, including MR angiography (MRA) and MR perfusion (MRP), plays a critical role in the diagnosis and surveillance of acute ischemic stroke. However, these techniques are hindered by the low T1 relaxivity, short circulation time, and high leakage rate from vessels of clinical Magnevist. To address these problems, nontoxic polyethylene glycol (PEG)ylated upconversion nanoprobes (PEG-UCNPs) are synthesized and first adopted for excellent MRA and MRP imaging, featuring high diagnostic sensitivity toward acute ischemic stroke in high-resolution imaging. The investigations show that the agent possesses superior advantages over clinical Magnevist, such as much higher relaxivity, longer circulation time, and lower leakage rate, which guarantee much better imaging efficiency. Remarkably, an extremely small dosage (5 mg Gd kg(-1) ) of PEG-UCNPs provides high-resolution MRA imaging with the vascular system delineated much clearer than the Magnevist with clinical dosage as high as 108 mg Gd kg(-1) . On the other hand, the long circulation time of PEG-UCNPs enables the surveillance of the progression of ischemic stroke using MRA or MRP. Once translated, these PEG-UCNPs are expected to be a promising candidate for substituting the clinical Magnevist in MRA and MRP, which will significantly lengthen the imaging time window and improve the overall diagnostic efficiency.

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Section: Resultsmentioning

confidence: 99%

High-Performance Upconversion Nanoprobes for Multimodal MR Imaging of Acute Ischemic Stroke

Wang

Zhang

et al. 2016

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“…13,14 DCE-MRI measures fractional blood plasma volume per unit volume of tissue (Vp) and time-dependent leakage (Ktrans), which reflect tissue perfusion and leakiness respectively. 15,16 Compared to DSC, DCE perfusion has the advantages of higher spatial resolution, better quantification of microvascular leakiness and perfusion, and increased resistance to susceptibility artifacts. 16,17 …”

Section: Introductionmentioning

confidence: 99%

Diagnostic Accuracy of T1-Weighted Dynamic Contrast-Enhanced–MRI and DWI-ADC for Differentiation of Glioblastoma and Primary CNS Lymphoma

Lin

Lee²,

Buck³

et al. 2016

AJNR Am J Neuroradiol

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Background Glioblastoma and primary CNS lymphoma (PCNSL) dictate different neurosurgical strategies; it is critical to distinguish between them preoperatively. However, current imaging modalities do not effectively differentiate them. We aim to examine the use of DWI and T1-weighted dynamic contrast-enhanced (DCE)-MRI as potential discriminative tools. Methods We retrospectively reviewed 18 PCNSL and 36 matched glioblastoma patients with pretreatment DWI- and DCE-MRI. VOIs were drawn around the tumor on contrast-enhanced T1WI and FLAIR images; these images were transferred onto coregistered ADC maps to obtain ADC, and onto DCE perfusion maps to obtain plasma volume (Vp) and permeability transfer constant (Ktrans). Histogram analysis was performed to determine mean (ADCmean) and relative ADCmean (rADCmean), and relative 90th percentile values for plasma volume (rVp90%tile) and permeability transfer constant (rKtrans90%tile). Non-parametric tests were used to assess differences and ROC analysis was performed for optimal threshold calculations. Results The enhancing component of PCNSL was found to have significantly lower ADCmean (1.1 × 103 vs 1.4 × 103; p<0.001) and rADCmean (1.5 vs 1.9; p<0.001) and rVp90%tile (3.7 vs 5.0; p<0.05) than the enhancing component of glioblastoma, but not significantly different rKtrans90%tile (5.4 vs 4.4; p=0.83). The non-enhancing portions of GBM and PCNSL did not differ in these parameters. Based on ROC analysis, mean ADC provided the best threshold (AUC 0.83) to distinguish primary CNS lymphoma from glioblastoma, which was not improved with normalized ADC or addition of perfusion parameters. Conclusion ADC was superior to DCE-MRI perfusion alone or in combination in differentiating PCNSL from glioblastoma.

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“…It may be chosen from a large artery—either manually or automatically (52)—or using a model-based approach to fit the individual signal (53). Traditionally, the same AIF is used for the entire brain, assuming that the delay between different parts of the brain in negligible.…”

Section: Introductionmentioning

confidence: 99%

Blood–Brain Barrier Imaging in Human Neuropathologies

Veksler

Shelef

Friedman

2014

Archives of Medical Research

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The blood–brain barrier (BBB) is essential for normal function of the brain, and its role in many brain pathologies has been the focus of numerous studies during the last decades. Dysfunction of the BBB is not only being shown in numerous brain diseases, but animal studies have indicated that it plays a direct key role in the genesis of neurovascular dysfunction and associated neurodegeneration. As such evidence accumulates, the need for robust and clinically applicable methods for minimally invasive assessment of BBB integrity is becoming urgent. This review provides an introduction to BBB imaging methods in the clinical scenario. First, imaging modalities are reviewed, with a focus on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). We then proceed to review image analysis methods, including quantitative and semi-quantitative methods. The advantages and limitations of each approach are discussed, and future directions and questions are highlighted.

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A review of technical aspects of T1-weighted dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in human brain tumors

Cited by 62 publications

References 85 publications

High-Performance Upconversion Nanoprobes for Multimodal MR Imaging of Acute Ischemic Stroke

High-Performance Upconversion Nanoprobes for Multimodal MR Imaging of Acute Ischemic Stroke

Diagnostic Accuracy of T1-Weighted Dynamic Contrast-Enhanced–MRI and DWI-ADC for Differentiation of Glioblastoma and Primary CNS Lymphoma

Blood–Brain Barrier Imaging in Human Neuropathologies

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