A review of some antimicrobial compounds isolated from medicinal plants reported in the literature 1978–1988

Redo, M. C.; Rı́os, José-Luis; Villar, A.

doi:10.1002/ptr.2650030402

Cited by 67 publications

(23 citation statements)

References 91 publications

(23 reference statements)

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“…The rational design of novel drugs from traditional medicine offers new prospects in modern healthcare [35–37]. Dietary habits are known to play a role in the prevention of osteoporosis.…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Tridax procumbens flavonoids promote osteoblast differentiation and bone formation

et al. 2015

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BackgroundTridax procumbens flavonoids (TPFs) are well known for their medicinal properties among local natives. Besides traditionally used for dropsy, anemia, arthritis, gout, asthma, ulcer, piles, and urinary problems, it is also used in treating gastric problems, body pain, and rheumatic pains of joints. TPFs have been reported to increase osteogenic functioning in mesenchymal stem cells. Our previous study showed that TPFs were significantly suppressed the RANKL-induced differentiation of osteoclasts and bone resorption. However, the effects of TPFs to promote osteoblasts differentiation and bone formation remain unclear. TPFs were isolated from Tridax procumbens and investigated for their effects on osteoblasts differentiation and bone formation by using primary mouse calvarial osteoblasts.ResultsTPFs promoted osteoblast differentiation in a dose-dependent manner demonstrated by up-regulation of alkaline phosphatase and osteocalcin. TPFs also upregulated osteoblast differentiation related genes, including osteocalcin, osterix, and Runx2 in primary osteoblasts. TPFs treated primary osteoblast cells showed significant upregulation of bone morphogenetic proteins (BMPs) including Bmp-2, Bmp-4, and Bmp-7. Addition of noggin, a BMP specific-antagonist, inhibited TPFs induced upregulation of the osteocalcin, osterix, and Runx2.ConclusionOur findings point towards the induction of osteoblast differentiation by TPFs and suggested that TPFs could be a potential anabolic agent to treat patients with bone loss-associated diseases such as osteoporosis.

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Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Tridax procumbens flavonoids promote osteoblast differentiation and bone formation

et al. 2015

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“…Traditional medicines play an important role in health services around the globe. The rational design of novel drugs from traditional medicine offers new prospects in modern healthcare [6, 7, 15]. Dietary habits are known to play a role in the prevention of osteoporosis.…”

Section: Discussionmentioning

confidence: 99%

“…Progressive bone destruction in RA involves the abnormal activation of osteoclasts, which is due to interactions with synovial fibroblasts and helper T cells that express the RANKL [4, 5]. Traditional medicine is an important source of potentially useful new compounds for the development of therapeutic agents [6]. Emergence of pathogenic microorganisms that are resistant or multi-resistant to major class of antibiotics has increased in recent years due to indiscriminate use of synthetic antimicrobial drugs [7].…”

Section: Introductionmentioning

confidence: 99%

Flavonoids isolated from Tridax procumbens (TPF) inhibit osteoclasts differentiation and bone resorption

et al. 2015

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BackgroundThe Tridax procumbens flavonoids (TPF), are well known for their medicinal properties among local natives. The TPF are traditionally used for dropsy, anaemia, arthritis, gout, asthma, ulcer, piles, and urinary problems. It also used in treating gastric problems, body pain, and rheumatic pains of joints. The TPF have been reported to increase osteogenic functioning in mesenchymal stem cells. However, their effects on osteoclastogenesis remain unclear. The TPF isolated from T. procumbens and investigated the effects of the TPF inhibit on osteoclast differentiation and bone resorption activities using primary osteoclastic cells. Osteoclast formation was assessed by counting the number of tartrate resistant acid phosphatase (TRAP) positive multinucleated cells and by measuring both TRAP activities.ResultsThe TPF significantly suppressed the RANKL-induced differentiation of osteoclasts and the formation of pits in primary osteoclastic cells. The TPF also decreased the expression of mRNAs related to osteoclast differentiation, including Trap, Cathepsin K, Mmp-9, and Mmp-13 in primary osteoclastic cells. The treatment of primary osteoclastic cells with the TPF decreased Cathepsin K, Mmp-9, and Mmp-13 proteins expression in primary osteoclastic cells.ConclusionThese results indicated that TPF inhibit osteoclastogenesis and pits formation activities. Our results suggest that the TPF could be a potential anti-bone resorptic agent to treat patients with bone loss-associated diseases such as osteoporosis.

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“…Plants contain numerous biologically active compounds, many of which have been shown to have antibacterial properties (Cowan 1999;Redo et al 1989). Researchers from divergent fields in the world have investigated plants with an eye to their antibacterial usefulness.…”

Section: Antibacterial Property Of Natural Fibre Plantsmentioning

confidence: 99%

“…The use of plants in medications has a long history, and it was usually the only method available in previous eras (Redo et al 1989). Interest in plants having antibacterial properties has been revived for many reasons, such as the public becoming increasingly aware of problems with the over-prescription and misuse of synthetic antibiotics (Cowan 1999).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Properties of Hemp and Other Natural Fibre Plants: A Review

Khan

Warner²,

Wang

2014

BioRes

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Intervention against pathogenic bacteria using natural plant material has a long history. Plant materials also have been widely used as fillers and/or reinforcers in polymer composites. Some natural fibre plants, such as hemp, are regarded to possess antibacterial activity against a wide range of pathogenic bacteria. Innovative applications can be explored if they are incorporated in polymer composites. This review aims to compile the relevant investigations on antibacterial activity of hemp and other fibre plants such as jute, flax, kenaf, sisal, and bamboo. The antibacterial character might be contributed from cannabinoids, alkaloids, other bioactive compounds, or phenolic compounds of lignin. This review is intended to encourage utilization of hemp and other natural fibre plants in value-added diversified products. Some potential applications are also discussed.

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A review of some antimicrobial compounds isolated from medicinal plants reported in the literature 1978–1988

Cited by 67 publications

References 91 publications

RETRACTED ARTICLE: Tridax procumbens flavonoids promote osteoblast differentiation and bone formation

RETRACTED ARTICLE: Tridax procumbens flavonoids promote osteoblast differentiation and bone formation

Flavonoids isolated from Tridax procumbens (TPF) inhibit osteoclasts differentiation and bone resorption

Antibacterial Properties of Hemp and Other Natural Fibre Plants: A Review

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