A Review of Selected Factors of Salivary Gland Tumour Formation and Malignant Transformation

Sowa, Paweł; Goroszkiewicz, Karolina; Szydełko, Joanna; Chechlinska, Joanna; Pluta, Katarzyna; Domka, Wojciech; Misiołek, Maciej; Ścierski, Wojciech

doi:10.1155/2018/2897827

Cited by 23 publications

(10 citation statements)

References 69 publications

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“…Even though the majority of SFTs follow a benign itinerary, a small percentage become malignant, or they can present zones of dedifferentiation of epithelial neoplasm mimicry [ 53 ]. De novo formation of SGTs, in addition to malignancy, is appointed to a plethora of signaling elements, the foremost hallmark being angiogenesis, evidenced through factors like VEGF and CD105 (endoglin) [ 54 ].…”

Section: Changes In Salivary Glands Cell Repertoirementioning

confidence: 99%

A Synopsis of Signaling Crosstalk of Pericytes and Endothelial Cells in Salivary Gland

Cucu

Nicolescu

2021

Dentistry Journal

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The salivary gland (SG) microvasculature constitutes a dynamic cellular organization instrumental to preserving tissue stability and homeostasis. The interplay between pericytes (PCs) and endothelial cells (ECs) culminates as a key ingredient that coordinates the development, maturation, and integrity of vessel building blocks. PCs, as a variety of mesenchymal stem cells, enthrall in the field of regenerative medicine, supporting the notion of regeneration and repair. PC-EC interconnections are pivotal in the kinetic and intricate process of angiogenesis during both embryological and post-natal development. The disruption of this complex interlinkage corresponds to SG pathogenesis, including inflammation, autoimmune disorders (Sjögren’s syndrome), and tumorigenesis. Here, we provided a global portrayal of major signaling pathways between PCs and ECs that cooperate to enhance vascular steadiness through the synergistic interchange. Additionally, we delineated how the crosstalk among molecular networks affiliate to contribute to a malignant context. Additionally, within SG microarchitecture, telocytes and myoepithelial cells assemble a labyrinthine companionship, which together with PCs appear to synchronize the regenerative potential of parenchymal constituents. By underscoring the intricacy of signaling cascades within cellular latticework, this review sketched a perceptive basis for target-selective drugs to safeguard SG function.

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Section: Changes In Salivary Glands Cell Repertoirementioning

confidence: 99%

A Synopsis of Signaling Crosstalk of Pericytes and Endothelial Cells in Salivary Gland

Cucu

Nicolescu

2021

Dentistry Journal

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“…De novo SGC formation as also the malignant transformation of benign SGTs is a complex phenomenon and depends on a variety of different elements, most crucial of which are reported to be cell cycle regulators such as cyclins, tumour suppressors and transcription factors, histotype-specific oncogenes such as mucoepidermoid carcinoma translocated-1 (MECT1) for MEC and v-myb avian myeloblastosis viral oncogene homolog (MYB) for ACC, various proteins including β-catenin, defensins, tenascin, and mucins, the adipocytokines leptin, ghrelin and adiponectin and finally angiogenesis factors, such as Vascular Endothelial Growth Factor (VEGF) and CD105 [11].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Angiogenesis in the Most Common Salivary Gland Malignant Tumors

Pouloudi

Sotiriadis

Theodorakidou

et al. 2020

IJMS

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Salivary gland carcinomas (SGCs) represent a group of rare tumors, with complete surgical resection being the main treatment option. Therapeutic armory for cases of locally aggressive, recurrent, and/or metastatic SGCs, though, remains poor since they exhibit high rates of resistance to systematic therapy. Angiogenesis is considered one of the contemporary hallmarks of cancer and anti-angiogenic factors have already been approved for the treatment of several cancer types. This review aims to summarize, in a histotype-specific manner, the most current available data on the angiogenic factors implicated in SGC angiogenesis, in order to highlight the differences between the most common SGC histotypes and the factors that may have a potential role as therapeutic targets.

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“…About 5-6% of all head and neck tumours originate from one or the other salivary gland. 7,8 Its incidence has been reported to be 5-6 per 100000 individuals in United States. These neoplasms are more likely to occur in relatively old age (6th decade), benign salivary gland tumors usually occur relatively earlier (4-5th decade).…”

Section: Discussionmentioning

confidence: 99%

“…These neoplasms are more likely to occur in relatively old age (6th decade), benign salivary gland tumors usually occur relatively earlier (4-5th decade). [8][9][10] Benign salivary gland neoplasms are more common in females whereas malignant tumours show equal distribution amongst males as well as females. The most common salivary glands to be involved in neoplastic pathology include parotid gland followed by submandibular gland and sublingual gland.…”

Section: Discussionmentioning

confidence: 99%

Salivary gland tumours: a retrospective study at a tertiary care centre in South India

Swarnkar

Srinivasan

Saravanam

2021

Int J Otorhinolaryngol Head Neck Surg

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Background: Salivary gland tumors are morphologically and histologically diverse group of lesions and their frequency varies in several parts of the world. Better understanding of these tumours will help in assessing the behaviour and outcomes of lesions of this region. The aim of this study was to analyse the charactertistics of different tumours occurring in the salivary gland in a tertiary care centre in South India.Methods: A retrospective study was conducted of salivary gland tumors diagnosed from the year 2015 to 2020. Patient age and gender, tumor site and frequency, histopathological diagnosis were evaluated and analysed.Results: A total of 36 salivary gland tumor cases was identified, 30 (87.3%) of which were classified as benign and 6 (12.7%) as malignant. Most tumors occurred in the parotid gland (81.3%). Pleomorphic adenoma was the most common tumor in 23 patients (63.8%), followed by warthins tumour. The tumors occurred more often in women than men.Conclusion: The results of the present study reinforce prevalence of salivary gland tumours. The parotid gland is the most common location and pleomorphic adenoma are the most frequent lesions. The malignant tumors also can occur in these glands and good clinical suspicion is necessary.

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A Review of Selected Factors of Salivary Gland Tumour Formation and Malignant Transformation

Cited by 23 publications

References 69 publications

A Synopsis of Signaling Crosstalk of Pericytes and Endothelial Cells in Salivary Gland

A Synopsis of Signaling Crosstalk of Pericytes and Endothelial Cells in Salivary Gland

The Impact of Angiogenesis in the Most Common Salivary Gland Malignant Tumors

Salivary gland tumours: a retrospective study at a tertiary care centre in South India

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