A Review of Rhazya stricta Decne Phytochemistry, Bioactivities, Pharmacological Activities, Toxicity, and Folkloric Medicinal Uses

Abstract

The local medicinal plant Rhazya stricta Decne is reviewed for its folkloric medicinal, phytochemical, pharmacological, biological, and toxicological features. R. stricta has been used widely in different cultures for various medical disorders. The phytochemical studies performed on the R. stricta extract revealed many alkaloidal and fatty acid compounds. Moreover, several flavonoid and terpenoid compounds were also detected. Pharmacological activates of R. stricta extracts are approved to possess antimicrobial, antioxidant, anticancer, antidiabetic, and antihypertensive activities. Additionally, R. stricta extract was found to hold biological activates such as larvicidal and phytoremediation activates R. stricta extract was found to be toxic, genotoxic, and mutagenic. R. stricta contains novel phytochemical compounds that have not been investigated pharmacologically. Further research is needed through in vitro and in vivo experiments to pave the road for these compounds for medical, veterinary, and ecological uses.

Phytochemical Analysis and Molecular Identification of Green Macroalgae Caulerpa spp. from Bali, Indonesia

“…Cyclohexanamine is considered the dominant chemical of Bulung Boni. This chemical can be found in several plants, such as Duddingtonia flagrans and Rhazya stricta [ 30 , 31 ]. D. flagrans showed the dominant presence of cyclohexanamine.…”

Evaluation of cytotoxicity and antiviral activity of Rhazya stricta Decne leaves extract against influenza A/PR/8/34 (H1N1)

“…Lots of studies screened the phytochemical ingredients of R. stricta extract. Over a hundred alkaloids and several additional chemicals, including flavonoids and lipids, have been identified ( Albeshri et al, 2021 ).…”

Effects of Aqueous and Ethanolic Extract of Rhazya stricta on Control of Date Contamination Under In Vitro Conditions

“…Chloroformic and methanolic extracts of R. stricta roots exhibited antimicrobial activity against B. subtilis, E. coli, S. aureus, and P. aeruginosa (11). The antibacterial activity of R. stricta leaf extracts at various concentrations was examined, showing that the organic alkaloid extract was most effective against E. coli (10).…”

“…Methanolic and chloroformic extracts of roots have antimicrobial and antifungal activity against E. coli, Aspergillus flavus, A. terreus, B. subtilis, S. aureus, and C. albicans. Aqueous extract of R. stricta has antimicrobial activity against Neisseria meningitides (10)(11)(12)(13)(14)(15)(16). Rhazya stricta and its metabolites help cure cancer, skin diseases, hypertension, rheumatism, sore throat, syphilis, and fever (17).…”