A review of research examining the regulatory role of lymphocytes in normal wound healing

Keen, Delia

doi:10.12968/jowc.2008.17.5.29173

Cited by 19 publications

(12 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…T lymphocytes also play a regulatory role in inflammation and wound healing. Cytokines and chemokines secreted by T H 2 cells such as IL-4, IL-10, and IL-13 affect polarization of macrophages, inducing an “alternative” activation program which results in M2-type macrophages involved in wound healing and activation of B-cells followed by a humoral immune reaction [ 25 , 28 – 30 ].…”

Section: Discussionmentioning

confidence: 99%

Acute and Chronic Local Inflammatory Reaction after Implantation of Different Extracellular Porcine Dermis Collagen Matrices in Rats

Lucke

Hoene

Walschus

et al. 2015

BioMed Research International

View full text Add to dashboard Cite

Two cross-linked acellular porcine dermal collagen matrices (Permacol and NRX) were implanted into rats and the acute and chronic local inflammatory tissue reactions were investigated after 7, 14, 28, and 112 days. Both membranes were stable in vivo for up to 112 days. All investigated immune cell populations (CD68+ macrophages, CD163+ macrophages, T lymphocytes, MHC class II positive cells, mast cells, and NK cells) were present. Their amount decreased significantly over time compared to day 7 after implantation. A change from an acute to a chronic inflammation and an associated shift from proinflammatory M1-like to anti-inflammatory M2-like macrophages were observed. In the early phase there was a significant correlation of T cells to CD68+ (M1-like) macrophages, whereas in the chronic phase T lymphocytes were positively correlated with CD163+ (M2-like) macrophages. The material NRX showed an enhanced inflammatory reaction in comparison to Permacol possibly caused by material characteristics such as a twofold higher thickness of the membrane, roughness, and water absorption capacity. Nevertheless, a more pronounced regenerative process as, for example, indicated by nestin expression demonstrated its possible suitability for applications as wound repair material.

show abstract

Section: Discussionmentioning

confidence: 99%

Acute and Chronic Local Inflammatory Reaction after Implantation of Different Extracellular Porcine Dermis Collagen Matrices in Rats

Lucke

Hoene

Walschus

et al. 2015

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…Macrophages also remove apoptotic neutrophils, the phagocytosis of which may lead to a change toward a more reparative (M2) macrophage phenotype and the resolution of the inflammatory phase of wound healing [94–96]. The T lymphocyte population also plays an important late regulatory role in the resolution of the inflammatory process through local secretion of cytokines and chemokines, many of which are known to affect macrophage polarization [97]. …”

Section: The Role Of Macrophage Polarization In Disease and Tissuementioning

confidence: 99%

Macrophage polarization: An opportunity for improved outcomes in biomaterials and regenerative medicine

et al. 2012

View full text Add to dashboard Cite

The host response to biomaterials has been studied for decades. Largely, the interaction of host immune cells, macrophages in particular, with implanted materials has been considered to be a precursor to granulation tissue formation, the classic foreign body reaction, and eventual encapsulation with associated negative impacts upon device functionality. However, more recently, it has been shown that macrophages, depending upon context dependent polarization profiles, are capable of affecting both detrimental and beneficial outcomes in a number of disease processes and in tissue remodeling following injury. Herein, the diverse roles played by macrophages in these processes are discussed in addition to the potential manipulation of macrophage effector mechanisms as a strategy for promoting site-appropriate and constructive tissue remodeling as opposed to deleterious persistent inflammation and scar tissue formation.

show abstract

“…In conclusion, the inhibition of hyaluronan synthesis by mannose, through reduction of cell migration, may contribute to the growth suppression of granulation tissue . The present data raise the possibility that granulation tissue growth was also suppressed by mannose because of its effect on leukocyte binding to hyaluronan in the wound area, as cytokines and growth factors secreted by leukocytes are important for granulation tissue growth and can further stimulate hyaluronan synthesis …”

Section: Discussionmentioning

confidence: 58%

Mannose reduces hyaluronan and leukocytes in wound granulation tissue and inhibits migration and hyaluronan‐dependent monocyte binding

Jokela

Kuokkanen

Kärnä

et al. 2013

Wound Repair Regeneration

View full text Add to dashboard Cite

Wound healing is a highly regulated process starting from coagulation and ending in tissue remodeling. The end result varies from perfectly restored tissue, such as in early fetal skin, to scars in adults. The balanced repair process is frequently disturbed by local or systemic factors, like infections and diabetes. A rapid increase of hyaluronan is an inherent feature of wounds and is associated with tissue swelling, epithelial and mesenchymal cell migration and proliferation, and induction of cytokine signaling. Hyaluronan extending from cell surface into structures called cables can trap leukocytes and platelets and change their functions. All these features of hyaluronan modulate inflammation. The present data show that mannose, a recently described inhibitor of hyaluronan synthesis, inhibits dermal fibroblast invasion and prevents the enhanced leukocyte binding to hyaluronan that takes place in cells treated with an inflammatory mediator interleukin-1β. Mannose also reduced hyaluronan in subcutaneous sponge granulation tissue, a model of skin wound, and suppressed its leukocyte recruitment and tissue growth. Mannose thus seems to suppress wounding-induced inflammation in skin by attenuating hyaluronan synthesis.

show abstract

A review of research examining the regulatory role of lymphocytes in normal wound healing

Abstract: Lymphocytes play a distinct, regulatory role in normal wound healing through the secretion of lymphokines. This paper evaluates the current research on the regulatory role of lymphocytes and their secretions in normal wound healing.

Cited by 19 publications

References 20 publications

Acute and Chronic Local Inflammatory Reaction after Implantation of Different Extracellular Porcine Dermis Collagen Matrices in Rats

Acute and Chronic Local Inflammatory Reaction after Implantation of Different Extracellular Porcine Dermis Collagen Matrices in Rats

Macrophage polarization: An opportunity for improved outcomes in biomaterials and regenerative medicine

Mannose reduces hyaluronan and leukocytes in wound granulation tissue and inhibits migration and hyaluronan‐dependent monocyte binding

Contact Info

Product

Resources

About