Acute and Chronic Local Inflammatory Reaction after Implantation of Different Extracellular Porcine Dermis Collagen Matrices in Rats

Lucke, Silke; Hoene, Andreas; Walschus, Uwe; Kob, Anette; Pissarek, Jens-Wolfgang; Schlosser, Michael

doi:10.1155/2015/938059

Cited by 24 publications

(12 citation statements)

References 35 publications

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“…These macrophages attract fibroblasts to the site 2007). Although only encapsulation was noted in this study, the walling off and/or ejection of foreign objects that the immune system cannot eradicate is a typical response across phyla (Anderson, 1971, Battistella et al, 1996, Lucke et al, 2014, Olsen et al, 2015. Likely with a longer trial duration, tag expulsion would have been evident in this study and is something that will be explored in future experiments.…”

Section: Healing Rate and Tag Encapsulationmentioning

confidence: 75%

Long-term implantation of acoustic transmitters induces chronic inflammatory cytokine expression in adult rainbow trout (Oncorhynchus mykiss)

Semple

Mulder

Rodríguez‐Ramos

et al. 2018

Veterinary Immunology and Immunopathology

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Highlights Presence of an acoustic transmitter did not influence surgical site healing rate  Tags were encapsulated inside the peritoneum as early as 15 days post-surgery  Spleen and surgical site cytokine expression was not influenced by tag presence  Tag presence increased inflammatory cytokine expression in peritoneal immune cells  At day 70 mature females had lower cytokine gene expression when compared to males AbstractTelemetry transmitters are frequently used in studies of wild fish migration and behavior. Although the effects of surgically implanted transmitters on survival, tag retention, healing and growth have been studied, there has been little research regarding the potential immune response induced by these transmitters. In the current study, mature rainbow trout received either surgical implantation of an acoustic transmitter or a sham surgical procedure. These fish were then sampled over a 10-week period so that pro-inflammatory cytokine expression in the spleen, peritoneal cavity lymphocytes and muscle at the surgical site could be analyzed. There were no significant differences in transcript expression for the spleen and muscle tissue between fish that had a transmitter and those that received the surgical procedure alone. However, transmitter presence significantly increased the expression of IL-6, IL-1β and TNFα in the peritoneal cells at 10 weeks indicating that tagged fish may be coping with chronic inflammation. Furthermore, tagged male fish had a higher inflammatory response in 10-week peritoneal lavage samples when compared to their tagged mature female counterparts, providing some evidence that mature female rainbow trout may have suppressed immune function when sexually mature. Externally, fish appeared to heal at similar rates regardless of the presence or absence of the transmitter, but the tag itself was prone to encapsulation and adhesion to the body wall and/or surgical site. This suggests that fish tagged with large intraperitoneal implants may not behave similarly to their wild counterparts. This research could aid in the development of improved telemetry tags that are more biocompatible, economical and better able to track fish behavior/movement.

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Section: Healing Rate and Tag Encapsulationmentioning

confidence: 75%

Long-term implantation of acoustic transmitters induces chronic inflammatory cytokine expression in adult rainbow trout (Oncorhynchus mykiss)

Semple

Mulder

Rodríguez‐Ramos

et al. 2018

Veterinary Immunology and Immunopathology

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“…Moreover, they present a high risk of pathogenic/viral contamination and may lead to immune rejection when isolated from different sources [ 11 , 12 ]. Although collagen exhibits good potential for tissue regeneration and is often used in various biomedical applications, this biopolymer may induce a local inflammatory reaction after implantation [ 13 ]. In contrast, such a phenomenon is not observed with synthetic polymers due to their low immunogenicity [ 14 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…Xenogeneic collagen matrix membranes indicate good tissue regeneration potential since they induce vascularization, cell migration, adhesion, and connective tissue formation [ 9 , 10 ]. However, these membranes are difficult to handle, control, purify, and sterilize, increasing the risk of pathogenic/viral contamination, immunoreactivity [ 11 , 12 ], and severe post-implant inflammation [ 13 ]. Several advantages posed by synthetic polymers when compared to natural polymers lie in their reduced immunogenicity and disease transmission potential [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Polydioxanone-Based Membranes for Bone Regeneration

Saska¹,

Pilatti²,

Silva³

et al. 2021

Polymers

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Resorbable synthetic and natural polymer-based membranes have been extensively studied for guided tissue regeneration. Alloplastic biomaterials are often used for tissue regeneration due to their lower immunoreactivity when compared with allogeneic and xenogeneic materials. Plenum® Guide is a synthetic membrane material based on polydioxanone (PDO), whose surface morphology closely mimics the extracellular matrix. In this study, Plenum® Guide was compared with collagen membranes as a barrier material for bone-tissue regeneration in terms of acute and subchronic systemic toxicity. Moreover, characterizations such as morphology, thermal analysis (Tm = 107.35 °C and crystallinity degree = 52.86 ± 2.97 %, final product), swelling (thickness: 0.25 mm ≅ 436% and 0.5 mm ≅ 425% within 24 h), and mechanical tests (E = 30.1 ± 6.25 MPa; σ = 3.92 ± 0.28 MPa; ε = 287.96 ± 34.68%, final product) were performed. The in vivo results revealed that the PDO membranes induced a slightly higher quantity of newly formed bone tissue than the control group (score: treated group = 15, control group = 13) without detectable systemic toxicity (clinical signs and evaluation of the membranes after necropsy did not result in differences between groups, i.e., non-reaction -> tissue-reaction index = 1.3), showing that these synthetic membranes have the essential characteristics for an effective tissue regeneration. Human adipose-derived stem cells (hASCs) were seeded on PDO membranes; results demonstrated efficient cell migration, adhesion, spread, and proliferation, such that there was a slightly better hASC osteogenic differentiation on PDO than on collagen membranes. Hence, Plenum® Guide membranes are a safe and efficient alternative for resorbable membranes for tissue regeneration.

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“…MegaDerm ® further offers an immunogenic benefit. The safety of acellular dermal matrix allografts has been well demonstrated in both animal 10 11 and clinical studies 12 . Moreover, MegaDerm ® is a sterile allograft produced by removing the antigenic target of cell-mediated rejection.…”

Section: Discussionmentioning

confidence: 98%

Surgical outcomes of tympanoplasty using a sterile acellular dermal allograft: a prospective randomised controlled study

Lee

Seo

Shim

et al. 2018

Acta Otorhinolaryngol Ital

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Acute and Chronic Local Inflammatory Reaction after Implantation of Different Extracellular Porcine Dermis Collagen Matrices in Rats

Cited by 24 publications

References 35 publications

Long-term implantation of acoustic transmitters induces chronic inflammatory cytokine expression in adult rainbow trout (Oncorhynchus mykiss)

Long-term implantation of acoustic transmitters induces chronic inflammatory cytokine expression in adult rainbow trout (Oncorhynchus mykiss)

Polydioxanone-Based Membranes for Bone Regeneration

Surgical outcomes of tympanoplasty using a sterile acellular dermal allograft: a prospective randomised controlled study

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