1982
DOI: 10.1016/0192-0561(82)90055-8
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A review of recent contributions on biologically active products of arachidonate conversion

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Cited by 37 publications
(9 citation statements)
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“…The ability of LTE4 to augment responsiveness to histamine may be particularly pertinent in vivo, since there is bioconversion of LTC4 and LTD4 to LTE4 during the contractile response with isolated muscle (24) and because LTE4 is the most biologically stable of the SRS-A leukotrienes in plasma or in the presence of activated cells (25,26 (1 and 10 ,ug/ml) and of indomethacin (Indo, 1 Ag/ml). NS, not significant.…”
Section: Discussionmentioning
confidence: 99%
“…The ability of LTE4 to augment responsiveness to histamine may be particularly pertinent in vivo, since there is bioconversion of LTC4 and LTD4 to LTE4 during the contractile response with isolated muscle (24) and because LTE4 is the most biologically stable of the SRS-A leukotrienes in plasma or in the presence of activated cells (25,26 (1 and 10 ,ug/ml) and of indomethacin (Indo, 1 Ag/ml). NS, not significant.…”
Section: Discussionmentioning
confidence: 99%
“…The newly synthesised mediators of ana phylaxis are produced by the oxidative me tabolism of arachidonic acid which is liber ated from the cell membrane upon stimula tion [27,28], Metabolism of this compound occurs by two main routes, namely the lipox ygenase pathway which leads to the produc tion of leukotrienes and the cyclooxygenase pathway which generates prostaglandins and thromboxanes. These agents have highly po tent vasoactive, spasmogenic and chemotac tic activities and may thereby play a major role in human allergic disease.…”
Section: Differences In Mast Cell Mediatorsmentioning
confidence: 99%
“…Using a sensitive bioassay procedure, DAVIDSON et al (I982) found LTB4 levels in synovial fluid from patients with rheumatoid arthritis of 0.3 ng/ml which is 400 times less than those reported by KLICKSTEIN et al (I980). Recently material in rheumatoid synovial fluid has been detected that reacts antigenically with antibodies to LTD 4 pointing to the presence of leukotrienes including LTD4 which may augment the inflammatory process (LEWIS et al 1982 ). LTB4 has also been found in sputum from patients with cystic fibrosis, the meaning of which is not as yet clear (CROMWELL et al I98I).…”
Section: Role Of Leukotriene B4 In Inflammationmentioning
confidence: 97%
“…The influence of histamine on compliance is of a much shorter duration than that of the leukotrienes. In the form of an aerosol LTC4 has been administered to monkeys and healthy human volunteers resulting in a decrease in peak expiratory flow and a relatively greater fall in dynamic compliance than in airway conductance (HOLROYDE et al I981;LEWIS et al 1982 al. 1979;SMEDEGXRD et al 198 I).…”
Section: Role Of Ltc4 Ltd4 and Lte4 In Allergymentioning
confidence: 99%