A review of recent contributions on biologically active products of arachidonate conversion

Lewis, Robert A.; Drazen, Jeffrey M.; Figueiredo, Joanne C.; Corey, E. J.; Austen, K. Frank

doi:10.1016/0192-0561(82)90055-8

Cited by 37 publications

(9 citation statements)

References 16 publications

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“…The ability of LTE4 to augment responsiveness to histamine may be particularly pertinent in vivo, since there is bioconversion of LTC4 and LTD4 to LTE4 during the contractile response with isolated muscle (24) and because LTE4 is the most biologically stable of the SRS-A leukotrienes in plasma or in the presence of activated cells (25,26 (1 and 10 ,ug/ml) and of indomethacin (Indo, 1 Ag/ml). NS, not significant.…”

Section: Discussionmentioning

confidence: 99%

Leukotriene E4-induced airway hyperresponsiveness of guinea pig tracheal smooth muscle to histamine and evidence for three separate sulfidopeptide leukotriene receptors.

Lee¹,

Austen²,

Corey³

et al. 1984

Proc. Natl. Acad. Sci. U.S.A.

118

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Bronchial hyperresponsiveness to contractile agonists and nonspecific irritants is a characteristic feature of bronchial asthma. The mechanisms causing this hyperirritability are unknown. The existence of separate receptors for leukotrienes C4 and D4 (LTCC4 and LTD4) has been, demonstrated previously by physiologic and radioligand binding studies. The rank order of potency of the sulfidopeptide leukotrienes for contracting tracheal spirals [leukotrwiene E4 (LTE4) > LID4 = LTC4J is different from that for contracting parenchymal strips (LTD4> LTE4> LTC4), thereby suggesting the existence of a separate receptor for LTE4. We now report that 'LTE4, the most stable of the leukotrienes comprising slow reacting substance of anaphylaxis, enhances the contractile response of guinea pig tracheal spirals but not of parenchymal strips, to histamine in a time-and dose-dependent fashion., The ability of LTE4 to increase histamine responsiveness occurred after removal of the free agonist and recovery of the tissues to baseline tensions and was not produced by lemkotrienes C4 and Lr4, which elicited the same magnitude of contraction of tracheal smooth muscle as LTE4. These findings suggest that LTE4-induced airway hyperirritability is not mediated by the contractile response per se and may be modiated through a receptor distinct from those for leukotrienes C4 and D4.

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Section: Discussionmentioning

confidence: 99%

Leukotriene E4-induced airway hyperresponsiveness of guinea pig tracheal smooth muscle to histamine and evidence for three separate sulfidopeptide leukotriene receptors.

Lee¹,

Austen²,

Corey³

et al. 1984

Proc. Natl. Acad. Sci. U.S.A.

118

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“…The newly synthesised mediators of ana phylaxis are produced by the oxidative me tabolism of arachidonic acid which is liber ated from the cell membrane upon stimula tion [27,28], Metabolism of this compound occurs by two main routes, namely the lipox ygenase pathway which leads to the produc tion of leukotrienes and the cyclooxygenase pathway which generates prostaglandins and thromboxanes. These agents have highly po tent vasoactive, spasmogenic and chemotac tic activities and may thereby play a major role in human allergic disease.…”

Section: Differences In Mast Cell Mediatorsmentioning

confidence: 99%

On the Heterogeneity of Mast Cells

Fl¹

1986

Pharmacology

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“…Using a sensitive bioassay procedure, DAVIDSON et al (I982) found LTB4 levels in synovial fluid from patients with rheumatoid arthritis of 0.3 ng/ml which is 400 times less than those reported by KLICKSTEIN et al (I980). Recently material in rheumatoid synovial fluid has been detected that reacts antigenically with antibodies to LTD 4 pointing to the presence of leukotrienes including LTD4 which may augment the inflammatory process (LEWIS et al 1982 ). LTB4 has also been found in sputum from patients with cystic fibrosis, the meaning of which is not as yet clear (CROMWELL et al I98I).…”

Section: Role Of Leukotriene B4 In Inflammationmentioning

confidence: 97%

“…The influence of histamine on compliance is of a much shorter duration than that of the leukotrienes. In the form of an aerosol LTC4 has been administered to monkeys and healthy human volunteers resulting in a decrease in peak expiratory flow and a relatively greater fall in dynamic compliance than in airway conductance (HOLROYDE et al I981;LEWIS et al 1982 al. 1979;SMEDEGXRD et al 198 I).…”

Section: Role Of Ltc4 Ltd4 and Lte4 In Allergymentioning

confidence: 99%

Leukotrienes, allergy and inflammation

Nijkamp¹,

Sitsen²

1982

Pharmaceutisch Weekblad Scientific Edition

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Immunological and non-immunological injury induce as a result of the action of the enzyme lipoxygenase the release of a series of arachidonic acid metabolites known as leukotrienes. The leukotrienes play an important role in allergic and inflammatory disease. Leukotrienes C4, D4 and E4 which recently have been recognized as constituents of the allergic mediator slow reacting substance of anaphylaxis (SRS-A) induce powerful bronchoconstriction, plasma exudation and weal and flare responses. Leukotriene B4 is involved in the regulation of chemotaxis, chemokinesis and other aspects of both cellular and vascular inflammation. The development of specific lipoxygenase inhibitors may lead to a new class of drugs for the treatment of bronchial asthma and chronic inflammatory diseases.

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A review of recent contributions on biologically active products of arachidonate conversion

Cited by 37 publications

References 16 publications

Leukotriene E4-induced airway hyperresponsiveness of guinea pig tracheal smooth muscle to histamine and evidence for three separate sulfidopeptide leukotriene receptors.

Leukotriene E4-induced airway hyperresponsiveness of guinea pig tracheal smooth muscle to histamine and evidence for three separate sulfidopeptide leukotriene receptors.

On the Heterogeneity of Mast Cells

Leukotrienes, allergy and inflammation

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