1982
DOI: 10.1007/bf01959134
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Leukotrienes, allergy and inflammation

Abstract: Immunological and non-immunological injury induce as a result of the action of the enzyme lipoxygenase the release of a series of arachidonic acid metabolites known as leukotrienes. The leukotrienes play an important role in allergic and inflammatory disease. Leukotrienes C4, D4 and E4 which recently have been recognized as constituents of the allergic mediator slow reacting substance of anaphylaxis (SRS-A) induce powerful bronchoconstriction, plasma exudation and weal and flare responses. Leukotriene B4 is in… Show more

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Cited by 7 publications
(3 citation statements)
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References 39 publications
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“…Thus, leukotriene concentration increases at inflammation sites (Pirault & Bäck, 2018). LTC 4 , LTD 4 , and LTE 4 are high-reactivity substances present during anaphylaxis (Nijkamp & Sitsen, 1982). They play an essential role in the occurrence of allergy-related inflammations.…”
Section: Lox Inhibition Testmentioning
confidence: 99%
“…Thus, leukotriene concentration increases at inflammation sites (Pirault & Bäck, 2018). LTC 4 , LTD 4 , and LTE 4 are high-reactivity substances present during anaphylaxis (Nijkamp & Sitsen, 1982). They play an essential role in the occurrence of allergy-related inflammations.…”
Section: Lox Inhibition Testmentioning
confidence: 99%
“…Аллергические болезни и респираторные инфекции имеют ряд общих и (или) взаимопотенцирующих звеньев патогенеза. Гистамин, лейкотриены, проcтагландины, многие цитокины и хемокины являются медиаторами как аллергического, так и инфекционного воспаления [1][2][3][4][5].…”
Section: Introductionunclassified
“…4 arachidonic acid metabolites with 20 carbon chain backbones. 6,7 Platelet-activating factor (PAF), an important lipid mediator not derived from arachidonic acid, plays a similar role in allergic/ inammatory response. 8 Moreover, PAF is both released from and an activator of immune system cells and has the ability to aggregate platelets.…”
Section: Introductionmentioning
confidence: 99%