A review of recent advances in exosomes and allergic rhinitis

Zheng, Zhong; Yu, Yangyang

doi:10.3389/fphar.2022.1096984

Cited by 7 publications

(5 citation statements)

References 66 publications

(73 reference statements)

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“…Mammalian cells produce and secrete extracellular vesicles that contain a mix of proteins and nucleic acids. These vesicles are believed to play an intricate role in cell-to-cell communications [ 113 , 114 , 115 ]. The idea of using lipid bilayer membrane vesicles for the delivery of bioactive molecules to cells has been readily adopted by the drug delivery field of research [ 116 , 117 ].…”

Section: Principles Of Phage Displaymentioning

confidence: 99%

Improving Pharmacokinetics of Peptides Using Phage Display

Asar,

Newton-Northup,

Soendergaard

2024

Viruses

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Phage display is a versatile method often used in the discovery of peptides that targets disease-related biomarkers. A major advantage of this technology is the ease and cost efficiency of affinity selection, also known as biopanning, to identify novel peptides. While it is relatively straightforward to identify peptides with optimal binding affinity, the pharmacokinetics of the selected peptides often prove to be suboptimal. Therefore, careful consideration of the experimental conditions, including the choice of using in vitro, in situ, or in vivo affinity selections, is essential in generating peptides with high affinity and specificity that also demonstrate desirable pharmacokinetics. Specifically, in vivo biopanning, or the combination of in vitro, in situ, and in vivo affinity selections, has been proven to influence the biodistribution and clearance of peptides and peptide-conjugated nanoparticles. Additionally, the marked difference in properties between peptides and nanoparticles must be considered. While peptide biodistribution depends primarily on physiochemical properties and can be modified by amino acid modifications, the size and shape of nanoparticles also affect both absorption and distribution. Thus, optimization of the desired pharmacokinetic properties should be an important consideration in biopanning strategies to enable the selection of peptides and peptide-conjugated nanoparticles that effectively target biomarkers in vivo.

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Section: Principles Of Phage Displaymentioning

confidence: 99%

Improving Pharmacokinetics of Peptides Using Phage Display

Asar,

Newton-Northup,

Soendergaard

2024

Viruses

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show abstract

“…Therefore, allergen-carrying dex may be important targets for AR immunotherapy (17,18). Since the diverse and complex mode of information transfer between dex and various cells may serve an integral role in the occurrence and progression of AR, dex engineered to carry anti-allergic drugs may have the potential to interrupt the allergic and immune processes underlying AR on a novel level (5,19).…”

Section: Role Of Dendritic Cell-derived Exosomes In Allergic Rhinitis...mentioning

confidence: 99%

“…When allergens enter the body, they are presented by dcs to cd4 T cells to trigger allergic inflammatory responses, leading to the activation and maturation of dcs (2,3). Exosomes are secreted during the maturation and differentiation of dcs in AR (4,5). However, almost all cells and not only dcs can produce exosomes (5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

“…Exosomes are secreted during the maturation and differentiation of dcs in AR (4,5). However, almost all cells and not only dcs can produce exosomes (5)(6)(7)(8). Exosomes are cell-derived, nm-sized extracellular vesicles (EVs) that are formed through the endocytosis and inward budding of the endosomal membrane mediated by extracellular components and cell surface proteins.…”

Section: Introductionmentioning

confidence: 99%

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Role of dendritic cell‑derived exosomes in allergic rhinitis (Review)

Kang,

He,

Liu

et al. 2023

Int J Mol Med

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Allergic rhinitis (AR) is a common pathological condition in otorhinolaryngology. Its prevalence has been increasing worldwide and is becoming a major burden to the world population. dendritic cells (dcs) are typically activated and matured after capturing, phagocytosing, and processing allergens during the immunopathogenesis of AR. In addition, the process of dc activation and maturation is accompanied by the production of exosomes, which are cell-derived extracellular vesicles (EVs) that can carry proteins, lipids, nucleic acids, and other cargoes involved in intercellular communication and material transfer. In particular, dc-derived exosomes (dex) can participate in allergic immune responses, where the biological substances carried by them can have potentially important implications for both the pathogenesis and treatment of AR. dex can also be exploited to carry anti-allergy agents to effectively treat AR. This provides a novel method to explore the pathogenesis of and treatment strategies for AR further. Therefore, the present review focuses on the origin, composition, function, and biological characteristics of dcs, exosomes, and dex, in addition to the possible relationship between dex and AR.

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“…Furthermore, it was observed that MSC-sEV effectively mitigated ILC2-related allergic airway inflammation, potentially mediated by miR-146a-5p, thereby proposing MSC-sEV as a promising cell-free therapeutic approach for the management of allergic disorders . Exosomes could also lead to the occurrence and progression of allergic rhinitis …”

Section: Introductionmentioning

confidence: 99%

Cow’s Milk Allergy May Induce Lipid Metabolism Disorder in BALB/c Mice via Exosomes

Ma,

Xia,

Gong

et al. 2024

J. Agric. Food Chem.

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Allergic diseases and lipid-metabolism-disorder-derived diseases are both significant public health issues. Recent studies have shown that exosomes are associated with the course of allergic diseases and are involved in lipid metabolism. In this study, exosomes derived from cow's milk allergic (CMA) mice medially loaded lesser proteins favoring cholesterol metabolism. The levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-c) in the serum were increased in the CMA mice, and hepatic lipid deposition was observed in the liver, but these phenomena were improved by inhibiting the exosome release. Specifically, the higher expression of the sterol regulatory element binding factor 2 (SREBP2) protein and HMGCR gene in the liver of CMA mice indicated an increase in cholesterol synthesis. NPC1L1 was also highly expressed in the small intestine of CMA mice, and fecal TC level was decreased, suggesting that the reabsorption of cholesterol was elevated. The biosynthesis of cholesterol, the reverse cholesterol transport (RCT) process, and the synthesis of bile acid in the liver were improved by inhibiting exosome release, as well as the reabsorption of cholesterol in the small intestine. This study has for the first time demonstrated the lipid metabolism disorder caused by CMA, especially the important role of exosomes in food allergies and lipid metabolism.

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A review of recent advances in exosomes and allergic rhinitis

Cited by 7 publications

References 66 publications

Improving Pharmacokinetics of Peptides Using Phage Display

Improving Pharmacokinetics of Peptides Using Phage Display

Role of dendritic cell‑derived exosomes in allergic rhinitis (Review)

Cow’s Milk Allergy May Induce Lipid Metabolism Disorder in BALB/c Mice via Exosomes

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