A review of published data on acridine derivatives with different biological activities

Rupar, S Jelena; Dobričić, D Vladimir; Aleksic, Milivoje; Brborić, S Jasmina; Čudina, A Olivera

doi:10.5937/kgjsci1840083r

Cited by 20 publications

(12 citation statements)

References 45 publications

(25 reference statements)

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“…Acridine derivatives with substitutes at this position are characterized by marked antibacterial (Chen et al, 2019; Hamzi et al, 2013; Kudryavtseva, Bogatyrev, Sysoev, & Klimova, 2019; Sing, Kumar, Prasad, Sharma, & Silakari, 2011), antiviral (Lyakhov, Suveyzdis, Litvinova, Rybalko, & Dyadyun, 2000), anticancer (Cholewinski, Dzierzbicka, & Kolodziejczyk, 2011; de Mela Rego, de Sena, Moura, Jacob, et al, 2017; Demeunynck, Charmantray, & Martelli, 2001; Ismail et al, 2018; Kumar et al, 2017; Prajapati et al, 2017), antiprotozoal, antioxidant, antimalarial, antihelmintic, insectidal, fungicidal, and many other interesting biochemical and physical properties (Agili, 2018; Habeeb Unnisa Begum Nagma Fathima, Tasleem, 2018; Rupar, Dobričić, Aleksić, Brborić, & Čudina, 2018) (Figure 2).…”

Section: Introductionmentioning

confidence: 99%

A new look at 9‐substituted acridines with various biological activities

Kožurková

Sabolová

Kristián

2020

J of Applied Toxicology

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Heterocycles have long been the focus of intensive study in attempts to develop novel therapeutic compounds, and acridine, a polynuclear nitrogen molecule containing a heterocycle, has attracted a considerable amount of scientific attention. Acridine derivatives have been studied in detail and have been found to possess multitarget properties, which inhibit topoisomerase enzymes that regulate topological changes in DNA and interfere with the essential biological function of DNA. This article describes some recent advancements in the field of new 9-substituted acridine heterocyclic agents and describes both the structure and the structure-activity relationship of the most promising molecules. The article will also present the IC 50 values of the novel derivatives against various human cancer cell lines. The mini review also investigates the topoisomerase inhibition and antibacterial and antimalarial activity of these polycyclic aromatic derivatives.

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Section: Introductionmentioning

confidence: 99%

A new look at 9‐substituted acridines with various biological activities

Kožurková

Sabolová

Kristián

2020

J of Applied Toxicology

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“…Actually, there are already scores of acridines and their analogs that have been synthesized but not explored as CIs yet. Rupar et al [ 61 ], Prasher and Sharma [ 62 ], and Gensicka-Kowalewska et al [ 21 ] discussed many acridines and acridine-based compounds that have been synthesized recently for their biological activities. Importantly, this review encourages corrosion enthusiasts to look into these new acridines.…”

Section: Conclusion and Future Outlookmentioning

confidence: 99%

Acridine and Its Derivatives: Synthesis, Biological, and Anticorrosion Properties

et al. 2022

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The phenomenon of corrosion threatens metallic components, human safety, and the economy. Despite being eco-friendly and promising as a corrosion inhibitor, acridine has not been explored to its full potential. In this review, we have discussed multiple biological activities that acridines have been found to show in a bid to prove that they are environmentally benign and much less toxic than many inhibitors. Some synthetic routes to acridines and substituted acridines have also been discussed. Thereafter, a multitude of acridines and substituted acridines as corrosion inhibitors of different metals and alloys in various corrosive media have been highlighted. A short mechanistic insight into how acridine-based compounds function as corrosion inhibitors have also been included. We believe this review will generate an impression that there is still much to learn about previously reported acridines. In the wake of recent surges to find efficient and non-toxic corrosion inhibitors, acridines and their analogs could be an appropriate answer.

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“…Acridine derivatives (Figure 1) constitute a class of heterocyclic compounds that are currently the focus of intensified research due to their potential as anticancer drugs. Acridine derivatives such as amsacrine represent a well-studied class of multitargeted anticancer agents that generally operate by interfering with DNA synthesis and by inhibiting/poisoning Topo II (Buzun et al, 2020;de Almeida et al, 2016de Almeida et al, , 2017Kathiravan et al, 2016;Kathiravan et al, 2013;Kožurková et al, 2017;Liang et al, 2019;Panchal et al, 2020;Rupar et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Acridine derivatives as inhibitors/poisons of topoisomerase II

Kožurková

2021

J of Applied Toxicology

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The potential of acridines (amsacrine) as a topoisomerase II inhibitor or poison was first discovered in 1984, and since then, a considerable number of acridine derivatives have been tested as topoisomerase inhibitors/poisons, containing different substituents on the acridine chromophore. This review will discuss a series of studies published over the course of the last decade, which have investigated various novel acridine derivatives against topoisomerase II activity.

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A review of published data on acridine derivatives with different biological activities

Cited by 20 publications

References 45 publications

A new look at 9‐substituted acridines with various biological activities

A new look at 9‐substituted acridines with various biological activities

Acridine and Its Derivatives: Synthesis, Biological, and Anticorrosion Properties

Acridine derivatives as inhibitors/poisons of topoisomerase II

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