A Review of Porphyrin Metabolism With Special Reference to Childhood

Aldrich, Robert A.; Labbé, Robert F.; Talman, Ellen L.

doi:10.1097/00000441-195523060-00010

Cited by 16 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The diagnosis, symptoms, biochemistry, and treatment of the conditions have been more than adequately reviewed elsewhere (Aldrich, Labbe, and Talman, 1955;Peters et al, 1958;Goldberg and Rimington, 1962;Dogramaci, 1964;Tschudy et al, 1965;Ridley, Hierons, and Cavanagh, 1968;Ridley, 1969;Salokannel and Rhen, 1969;International Conference, 1971).…”

Section: Discussionmentioning

confidence: 99%

Acute intermittent porphyria in childhood. A neglected diagnosis?

Barclay¹

1974

Archives of Disease in Childhood

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Acute intermittent porphyria in childhood. A neglected diagnosis?

Barclay¹

1974

Archives of Disease in Childhood

View full text Add to dashboard Cite

“…The factors contributing to the porphyrinuria of lead poisoning remain incompletely understood. For the available evidence on the topic the reader is referred to several excellent reviews (1)(2)(3)(4). Several groups of investigators (5)(6)(7), have reported data indicating a correlation between the concentration of coproporphyrin in urine and the concentrations of lead in the blood and urine of untreated industrial lead workers.…”

mentioning

confidence: 99%

Quantitative Urinary Coproporphyrin Excretion and Its Relation to Edathamil Calcium Disodium Administration in Children With Acute Lead Intoxication 12

Chisolm¹,

Harrison²

1956

J. Clin. Invest.

View full text Add to dashboard Cite

The disturbance of porphyrin synthesis induced by lead in both humans and experimental animals results in an increased excretion of porphyrins in the urine. The factors contributing to the porphyrinuria of lead poisoning remain incompletely understood. For the available evidence on the topic the reader is referred to several excellent reviews ( 1-4). Several groups of investigators (5-7), have reported data indicating a correlation between the concentration of coproporphyrin in urine and the concentrations of lead in the blood and urine of untreated industrial lead workers. These investigators used semiquantitative techniques for the estimation of coproporphyrin in urine. Bashour (8) has-also reported a positive correlation (r = 0.37) between blood lead concentration and the quantitative excretion of coproporphyrin in the urine of lead-exposed adults.During a study of acute and chronic lead poisoning in children certain quantitative relationships became apparent between the total daily urinary coproporphyrin output and a) the urine lead output induced by edathamil calcium disodium administration,8 and b) whole blood lead concentration. MATERIALS AND METHODSThe data to be presented are based upon serial determinations of 24-hour urinary coproporphyrin output, 24-hour urine lead output and whole blood lead concentra-

show abstract

“…I t is well established that porphyrins have a widespread distribution and play a major role in metabolic processes in the animal and the vegetable kingdoms ( 1,2). Since previous workers ( 3,4) found that certain cellular enzymes have the ability to synthesize porphyrin from delta aminolevulinic acid, the presence and activity of porphyrin-producing enzymes have been determined for some tissues and organs of many animals ( 5 ) .…”

mentioning

confidence: 99%