A review of plant species assessedin?vitro for antiamoebic activity or both antiamoebic and antiplasmodial properties

Sharma, Poonam; Sharma, Jayashri Devi

doi:10.1002/1099-1573(200102)15:1<1::aid-ptr959>3.0.co;2-l

Cited by 30 publications

(15 citation statements)

References 49 publications

(12 reference statements)

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“…Medicinal plants contain a variety of secondary metabolites, which can be used to prevent or cure diseases, or to promote general health and well-being [2],[3]. During the last decades, scientific evidences of the medicinal values of plant products (through in vitro investigation) aroused public concerns about the conservation of such plants, in order to retain their economic and therapeutic significance [4]. Modern pharmaceutical industry relies mainly on the diversity of secondary metabolites in medicinal plants for the discovery of new compounds with novel biological properties.…”

Section: Introductionmentioning

confidence: 99%

Bioassay-Guided Fractionation of Extracts from Codiaeum variegatum against Entamoeba histolytica Discovers Compounds That Modify Expression of Ceramide Biosynthesis Related Genes

et al. 2014

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Leaves of Codiaeum variegatum (“garden croton”) are used against bloody diarrhoea by local populations in Cameroon. This study aims to search for the active components from C. variegatum against Entamoeba histolytica, and thereby initiate the study of their mechanism of action. A bioassay-guided screening of the aqueous extracts from C. variegatum leaves and various fractions was carried out against trophozoites of E. histolytica axenic culture. We found that the anti-amoebic activity of extracts changed with respect to the collection criteria of leaves. Thereby, optimal conditions were defined for leaves' collection to maximise the anti-amoebic activity of the extracts. A fractionation process was performed, and we identified several sub-fractions (or isolated compounds) with significantly higher anti-amoebic activity compared to the unfractionated aqueous extract. Anti-amoebic activity of the most potent fraction was confirmed with the morphological characteristics of induced death in trophozoites, including cell rounding and lysis. Differential gene expression analysis using high-throughput RNA sequencing implies the potential mechanism of its anti-amoebic activity by targeting ceramide, a bioactive lipid involved in disturbance of biochemical processes within the cell membrane including differentiation, proliferation, cell growth arrest and apoptosis. Regulation of ceramide biosynthesis pathway as a target for anti-amoebic compounds is a novel finding which could be an alternative for drug development against E. histolytica.

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Section: Introductionmentioning

confidence: 99%

Bioassay-Guided Fractionation of Extracts from Codiaeum variegatum against Entamoeba histolytica Discovers Compounds That Modify Expression of Ceramide Biosynthesis Related Genes

et al. 2014

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“…Benzene-1,4-dicarbaldehyde dioxime (1) and dioxazole derivatives (2)(3)(4)(5)(6)(7)(8)(9)(10)(11) were screened in vitro against HM1:IMSS strain of E. histolytica by microdilution method. All the experiments were carried out in triplicate at each concentration level and repeated thrice.…”

Section: Pharmacologymentioning

confidence: 99%

“…In addition, this drug has several adverse effects for which the most common are gastrointestinal disturbances, especially nausea, vomiting and diarrhoea or constipation may also occur [7]. Due to its adverse effects and the emergence of drug resistance [8,9], it is desirable to search for discovering and developing newer antiamoebic agents so that the limitation as presented by available therapeutic agents can be minimized and more safer, effective antiamoebic drugs or vaccines can come into existence.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, antiamoebic activity and toxicity of novel bisdioxazole derivatives

Iqbal

Parveen

Bhat

et al. 2009

European Journal of Medicinal Chemistry

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“…In addition, other reviews have reported the chemistry and synthesis [27] , and anticancer and antimalarial activities of quassinoids [31][32][33] . Sharma and Sharma (2001) [32] provided a comparative compilation of the various studies of quassinoids reported during 1982 -1999 from plants with antiplasmodial and …”

Section: (Nf 54 Asexual)mentioning

confidence: 99%

Antimalarial quassinoids: past, present and future

Muhammad

Samoylenko

2007

Expert Opinion on Drug Discovery

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This review is a compilation of the investigations reported to date on the sources, isolation, chemistry and antimalarial activities of natural quassinoids and their synthetic and semisynthetic analogs. It also provides an analysis of the in vitro structure-activity relationship of quassinoids for further evaluation in animal models. The introduction of non-nitrogenous antimalarial drugs has created a new era of malaria chemotherapy to treat Plasmodium falciparum strains that are resistant to existing nitrogenous drugs and the rising incidence of the deadly cerebral malaria. Many antimalarial quassinoids are discovered from simaroubaceous plants that are used traditionally to treat fever and malaria, thereby reiterating the critical role of ethnopharmacology as a rich source of novel drug discovery.

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A review of plant species assessedin?vitro for antiamoebic activity or both antiamoebic and antiplasmodial properties

Cited by 30 publications

References 49 publications

Bioassay-Guided Fractionation of Extracts from Codiaeum variegatum against Entamoeba histolytica Discovers Compounds That Modify Expression of Ceramide Biosynthesis Related Genes

Bioassay-Guided Fractionation of Extracts from Codiaeum variegatum against Entamoeba histolytica Discovers Compounds That Modify Expression of Ceramide Biosynthesis Related Genes

Synthesis, characterization, antiamoebic activity and toxicity of novel bisdioxazole derivatives

Antimalarial quassinoids: past, present and future

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